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浏览/检索结果: 共152条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Design, synthesis and biological evaluation of Alisol B derivatives for potential treatment of non-alcoholic steatohepatitis 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2025, 卷号: 155, 页码: 15 作者:  Yu, Nai-Rong;  Huang, Suling;  Deng, Zhen-Tao;  Wang, Jiayue;  Shen, Yu   |  收藏  |  浏览/下载：8/0  |  提交时间：2025/04/01 Non-alcoholic steatohepatitis (NASH)  Alisol B  Structural modification  Structure-activity relationship  HFD+CCl4-induced NASH mice model   A new mechanism of thyroid hormone receptor β agonists ameliorating nonalcoholic steatohepatitis by inhibiting intestinal lipid absorption via remodeling bile acid profiles 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2024, 页码: 15 作者:  Sun, Kai;  Zhu, Nan-lin;  Huang, Su-ling;  Qu, Hui;  Gu, Yi-pei   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/07/12 nonalcoholic steatohepatitis  THR beta agonists  resmetirom  bile acids composition  intestinal lipid absorption   TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 8, 页码: 1649-1664 作者:  Yang, Wen-ji;  Han, Fang-hui;  Gu, Yi-pei;  Qu, Hui;  Liu, Jia   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/03/27 TGR5 agonist  ulcerative colitis  intestinal epithelial cell  apoptosis  cAMP  PKA signaling pathway  c-FLIP   Discovery of Highly Potent and Selective Thyroid Hormone Receptor βAgonists for the Treatment of Nonalcoholic Steatohepatitis 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 5, 页码: 3284-3300 作者:  Hu, Liuyu;  Gu, Yipei;  Liang, Ju;  Ning, Mengmeng;  Yang, Junli   |  收藏  |  浏览/下载：18/0  |  提交时间：2024/03/27 Phenotypic screening-based drug discovery of furan-2-carboxylic acid derivatives for the amelioration of type 2 diabetes mellitus (T2DM) 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 246, 页码: 11 作者:     |  收藏  |  浏览/下载：33/0  |  提交时间：2023/04/10 Phenotypic screening  Gluconeogenesis  Furan-2-carboxylic acid  T2DM   Design and exploration of gut-restricted bifunctional molecule with TGR5 agonistic and DPP4 inhibitory effects for treating ulcerative colitis 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 242, 页码: 114697 作者:  Han, Fanghui;  Ning, Mengmeng;  Wang, Kai;  Gu, Yipei;  Qu, Hui   |  收藏  |  浏览/下载：26/0  |  提交时间：2024/03/21 Bifunctional molecule  Gut-restricted  Ulcerative colitis  TGR5  DPP4   Spin-orbit-parity coupled superconductivity in atomically thin 2M-WS2 期刊论文  OAI收割 NATURE PHYSICS, 2022 作者:  Zhang, Enze;  Xie, Ying-Ming;  Fang, Yuqiang;  Zhang, Jinglei;  Xu, Xian   |  收藏  |  浏览/下载：36/0  |  提交时间：2022/12/23 Development and structure–activity relationships of tanshinones as selective 11β-hydroxysteroid dehydrogenase 1 inhibitors 期刊论文  OAI收割 Natural Products and Bioprospecting, 2022, 卷号: 12, 期号: 1 作者:  Deng,Xu;  Huang,Su-Ling;  Ren,Jian;  Pan,Zheng-Hong;  Shen,Yu   |  收藏  |  浏览/下载：37/0  |  提交时间：2022/11/11 Metabolic syndrome  Tanshinones  Selective 11β-HSD1 inhibitors  Structure–activity relationships   Development and structure-activity relationships of tanshinones as selective 11beta-hydroxysteroid dehydrogenase 1 inhibitors 期刊论文  OAI收割 Natural products and bioprospecting, 2022, 卷号: 12, 期号: 1, 页码: 36 作者:  Deng, Xu;  Huang, Su-Ling;  Ren, Jian;  Pan, Zheng-Hong;  Shen, Yu   |  收藏  |  浏览/下载：23/0  |  提交时间：2024/03/15 Metabolic syndrome  Selective 11beta-HSD1 inhibitors  Structure-activity relationships  Tanshinones   Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 14 作者:  Huang, Su-Ling;  Xie, Wei;  Ye, Yang-Liang;  Liu, Jia;  Qu, Hui   |  收藏  |  浏览/下载：47/0  |  提交时间：2022/11/11 type 2 diabetes mellitus  coronarin A  glycogen synthesis  gluconeogenesis  mTORC1  IRS1