中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 12
作者:
He, Xin-heng
;
Li, Jun-rui
;
Shen, Shi-yi
;
Xu, H. Eric
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/01/14
AlphaFold
structure-based drug design
artificial intelligence
GPCR
structural biology
Synergism of salvianolic acid B and ginsenoside Rg1 magnifies the therapeutic potency against ischemic stroke
期刊论文
OAI收割
NEUROREPORT, 2024, 卷号: 35, 期号: 16, 页码: 1041-1051
作者:
Shen, Haishang
;
Zhang, Yuhan
;
Shao, Yanan
;
Chen, Siqi
;
Yin, Ping
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/11/26
Bliss independence statistical model
ginsenoside Rg1
glycerophospholipid metabolism
ischemic stroke
salvianolic acid B
synergistic effect
Design, Synthesis, and Biological Evaluation of HDAC Inhibitors Containing Natural Product-Inspired
N
-Linked 2-Acetylpyrrole Cap
期刊论文
OAI收割
MOLECULES, 2024, 卷号: 29, 期号: 19, 页码: 26
作者:
Zhang, Han
;
Shen, Qianqian
;
Hu, Zhu
;
Wu, Pei-Qian
;
Chen, Yi
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/11/26
HDAC inhibitors
anti-cancer activity
natural products
pyrrole derivatives
molecular docking
molecular dynamics simulation
AI-driven antibody design with generative diffusion models: current insights and future directions
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 10
作者:
He, Xin-heng
;
Li, Jun-rui
;
Xu, James
;
Shan, Hong
;
Shen, Shi-yi
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/11/05
antibodies
generative model
diffusion
de novo antibody design
CDR optimization
model evaluation
Redefinition of the Global Stratotype Section and Point (GSSP) and new Standard Auxiliary Boundary Stratotype (SABS) for the base of Wuchiapingian Stage (Lopingian Series, Permian) in South China
期刊论文
OAI收割
EPISODES, 2024, 卷号: 47, 期号: 1, 页码: 147-177
作者:
Shen, Shu-zhong
;
Yuan, Dong-xun
;
Zhang, Yi-chun
;
Henderson, Charles M.
;
Zheng, Quan-feng
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/10/10
Redefinition of the Global Stratotype Section and Point (GSSP) and new Standard Auxiliary Boundary Stratotype (SABS) for the base of Wuchiapingian Stage (Lopingian Series, Permian) in South China
期刊论文
OAI收割
EPISODES, 2024, 卷号: 47, 期号: 1, 页码: 147-177
作者:
Shen, Shu-zhong
;
Yuan, Dong-xun
;
Zhang, Yi-chun
;
Henderson, Charles M.
;
Zheng, Quan-feng
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/03/28
A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects
期刊论文
OAI收割
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 191, 页码: 9
作者:
Yang, Xin-Mei
;
Yang, Yang
;
Yao, Bu-Fan
;
Ye, Pan-Pan
;
Xu, Yan
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/12/11
COVID-19
Simnotrelvir
Safety
Pharmacokinetics
Healthy subjects
Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 259, 页码: 19
作者:
Wang, Pingyuan
;
Zhu, Wen-Ting
;
Wang, Yajing
;
Song, Shan-Shan
;
Xi, Yong
  |  
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2023/10/17
PARP1 inhibitor
Synthetic lethality
Drug resistance
Anticancer
Structure -activity relationship
Inconsistent patterns of Holocene rainfall changes at the East Asian monsoon margin compared to the core monsoon region
期刊论文
OAI收割
QUATERNARY SCIENCE REVIEWS, 2023, 卷号: 301, 页码: 10
作者:
Zhou, Xin
;
Zhan, Tao
;
Tan, Ning
;
Tu, Luyao
;
Smol, John P.
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2023/03/30
Holocene optimum
Crater lake sediment
Clastic material
Eolian dust
Monsoon margin
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance
期刊论文
OAI收割
EMBO MOLECULAR MEDICINE, 2023, 页码: 24
作者:
Wang, Li-Min
;
Wang, Pingyuan
;
Chen, Xiao-Min
;
Yang, Hui
;
Song, Shan-Shan
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2023/04/10
homologous recombination repair
olaparib-resistant
PARP inhibitor
PARP7
type I interferons