机构

• 上海药物研究所 [17]

采集方式

• OAI收割 [17]

内容类型

• 期刊论文 [17]

发表日期

• 2023 [2]
• 2022 [1]
• 2021 [1]
• 2020 [1]
• 2019 [1]
• 2018 [2]
• 更多

学科主题

筛选

浏览/检索结果: 共17条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of a novel GPR35 agonist with high and equipotent species potency for oral treatment of IBD 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 96, 页码: 12 作者:  Song, Zhaoxiang;  Lu, Dan;  Sun, Jun;  Ye, Yangliang;  Fang, Jiahui   |  收藏  |  浏览/下载：45/0  |  提交时间：2024/01/16 GPR35  IBD  Lodoxamide   Phenotypic screening-based drug discovery of furan-2-carboxylic acid derivatives for the amelioration of type 2 diabetes mellitus (T2DM) 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 246, 页码: 11 作者:  Chen, Lili;  Huang, Suling;  Ye, Yangliang;  Shen, Yu;  Xu, Tifei   |  收藏  |  浏览/下载：33/0  |  提交时间：2023/04/10 Phenotypic screening  Gluconeogenesis  Furan-2-carboxylic acid  T2DM   General Pharmacological Activation Mechanism of K+ Channels Bypassing Channel Gates 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 15 作者:  Liu, Shijie;  Guo, Peipei;  Wang, Kun;  Zhang, Shaoying;  Li, Ya   |  收藏  |  浏览/下载：51/0  |  提交时间：2022/08/30 Discovery of novel ketoxime ether derivatives with potent FXR agonistic activity, oral effectiveness and high liver/blood ratio 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 43, 页码: 13 作者:  Tang, Xuehang;  Ning, Mengmeng;  Ye, Yangliang;  Gu, Yipei;  Yan, Hongyi   |  收藏  |  浏览/下载：45/0  |  提交时间：2021/11/04 FXR agonist  Ketoxime ether  Target genes  Liver  blood ratio  Systemic activation   Design of G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) soft drugs with reduced gallbladder-filling effects 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 12 作者:  Han, Fanghui;  Ning, Mengmeng;  Cao, Hua;  Ye, Yangliang;  Feng, Ying   |  收藏  |  浏览/下载：27/0  |  提交时间：2020/12/21 Soft drug  TGR5  GLP-1  Gallbladder-filling effects  Rapid metabolism  Carboxylic ester   TGR5 agonist ameliorates insulin resistance in skeletal muscles and improves glucose homeostasis in diabetic mice 期刊论文  OAI收割 METABOLISM-CLINICAL AND EXPERIMENTAL, 2019, 卷号: 99, 页码: 45-56 作者:  Huang, Suling;  Ma, Shanyao;  Ning, Mengmeng;  Yang, Wenji;  Ye, Yangliang   |  收藏  |  浏览/下载：39/0  |  提交时间：2020/07/01 TGR5  Glucose homeostasis  Insulin resistance  Skeletal muscle  Type 2 diabetes   Design, synthesis and structure activity relationship studies of GPR40 agonists containing amide linker 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 175-194 作者:  Chen, Tingting;  Ning, Mengmeng;  Ye, Yangliang;  Wang, Kai;  Leng, Ying   |  收藏  |  浏览/下载：42/0  |  提交时间：2019/01/08 GPR40  FFAR1  Insulin secretion  Type 2 diabetes mellitus  CNS   Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3 期刊论文  OAI收割 FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9 作者:  Xie, Wei;  Ye, Yangliang;  Feng, Ying;  Xu, Tifei;  Huang, Suling   |  收藏  |  浏览/下载：57/0  |  提交时间：2019/01/08 cAMP  gluconeogenesis  linderane  phosphodiesterase  type 2 diabetes   Discovery and Structure-Activity Relationship Study of 4-Phenoxythiazol-5-carboxamides as Highly Potent TGR5 Agonists 期刊论文  OAI收割 CHEMICAL & PHARMACEUTICAL BULLETIN, 2016, 卷号: 64, 期号: 4, 页码: 326-339 作者:  Chen, Zhixiang;  Ning, Mengmeng;  Zou, Qingan;  Cao, Hua;  Ye, Yangliang   |  收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08 Takeda G-protein-coupled receptor 5 agonist  bioisostere  microsomal clearance  structure-activity relationship   ol3anovellowabsorbedtgr5agonistwithreducedsideeffectsloweredbloodglucoseviadualactionsontgr5activationanddpp4inhibition 期刊论文  OAI收割 actapharmacologicasinica, 2016, 卷号: 000, 期号: 010, 页码: 1359 作者:  Ma Shanyao;  Ning Mengmeng;  Zou Qingan;  Feng Ying;  Ye Yangliang   |  收藏  |  浏览/下载：16/0  |  提交时间：2020/07/01 OL3  MN6  linagliptin  TGR5 agonist  DPP4 inhibitor  GLP-1  low-absorbed  gallbladder filling  type 2 diabetes mellitus