机构

• 上海药物研究所 [12]
• 金属研究所 [3]
• 上海神经科学研究所 [1]
• 昆明植物研究所 [1]
• 合肥物质科学研究院 [1]

采集方式

• OAI收割 [18]

内容类型

• 期刊论文 [18]

发表日期

• 2025 [1]
• 2021 [3]
• 2018 [4]
• 2017 [3]
• 2016 [1]
• 2015 [4]
• 更多

学科主题

• Neuroscien... [1]

筛选

浏览/检索结果: 共18条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466 作者:  Li, Yang;  Fang, Yan;  Chen, Xiaoyu;  Tong, Linjiang;  Feng, Fang   |  收藏  |  浏览/下载：16/0  |  提交时间：2025/04/01 P21-activated kinase 4  Tetrahydrobenzofuro[2  3-c]pyridine  Structure-activity relationship  Allosteric inhibitor  Pharmacokinetics properties  Kinase selectivity  Pancreatic cancer  Immune infiltration   Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9 作者:  Liu, Xiao;  Yang, Su;  Hart, Jonathan R.;  Xu, Yingna;  Zou, Xinyu   |  收藏  |  浏览/下载：69/0  |  提交时间：2022/01/04 phosphoinositide 3-kinase (PI3K)  activation  inhibition  activity-dependent conformational changes   Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794 作者:  Wu, Xiaowei;  Dai, Mengdi;  Cui, Rongrong;  Wang, Yulan;  Li, Chunpu   |  收藏  |  浏览/下载：55/0  |  提交时间：2021/05/24 Tyrosine kinase  Covalent FGFR inhibitors  Virtual screening  Pyrazolo[3,4-d] pyridazinone  Structure-activity relationships  Antitumor efficacy   Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer 期刊论文  OAI收割 CANCER CELL INTERNATIONAL, 2021, 卷号: 21, 期号: 1, 页码: 697 作者:  He,YingYing;  He,Zhicheng;  Zhang,Xiaoyu;  Liu,Shubai   |  收藏  |  浏览/下载：58/0  |  提交时间：2022/04/02 Ovarian cancer  Ester lipid  Tyrosine kinase signaling pathway  Platelet-activating factor  FACTOR-ACETYLHYDROLASE ACTIVITY  LYSOPHOSPHATIDIC ACID  FACTOR RECEPTOR  EMERGING ROLE  EXPRESSION  GROWTH  PAF  MECHANISMS  PAFAH1B3  SUBUNIT   Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3K alpha H1047R mutant inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 707-719 作者:  Zhang, Ning;  Yu, Zhimei;  Yang, Xiaohong;  Zhou, Yan;  Wang, Jia   |  收藏  |  浏览/下载：95/0  |  提交时间：2019/01/08 Anticancer drug  Phosphatidylinositol 3-kinase  Structure-activity relationship   Difuran-substituted quinoxalines as a novel class of PI3K alpha H1047R mutant inhibitors: Synthesis, biological evaluation and structure activity relationship 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 157, 页码: 37-49 作者:  Zhang, Ning;  Yu, Zhimei;  Yang, Xiaohong;  Zhou, Yan;  Tang, Qing   |  收藏  |  浏览/下载：41/0  |  提交时间：2019/01/08 Proliferation  Anticancer drug  Phosphatidylinositol 3-kinase inhibitor  Apoptosis  Structure-activity relationship   Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3K delta) inhibitor 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 156, 页码: 831-846 作者:  Liang, Xiaofei;  Li, Feng;  Chen, Cheng;  Jiang, Zongru;  Wang, Aoli   |  收藏  |  浏览/下载：43/0  |  提交时间：2019/12/10 PI3K delta  Kinase inhibitor  Acute myeloid leukemia  Structure-activity relationship   targetingthepi3kaktmtorsignalingpathwaybypterostilbeneattenuatesmantlecelllymphomaprogression 期刊论文  OAI收割 actabiochimicaetbiophysicasinica, 2018, 卷号: 50, 期号: 8, 页码: 782 作者:  Yu Dandan;  Zhang Yong;  Chen Gege;  Xie Yongsheng;  Xu Zhijian   |  收藏  |  浏览/下载：31/0  |  提交时间：2020/07/01 PROTEIN-KINASE PATHWAY  CANCER IN-VITRO  TRANSDUCTION PATHWAYS  CYCLE ARREST  APOPTOSIS  ACTIVATION  PATHOGENESIS  INHIBITION  ANTICANCER  EXPRESSION  mantle cell lymphoma  pterostilbene  antiproliferative activity  PI3K/Akt/mTOR pathway  synergistic cytotoxicity   Synthesis and structure-activity relationship study of pyrazolo[3,4-d]pyrimidines as tyrosine kinase RET inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 11, 页码: 2544-2548 作者:  Wang, Chengyan;  Liu, Hongchun;  Song, Zilan;  Ji, Yinchun;  Xing, Li   |  收藏  |  浏览/下载：42/0  |  提交时间：2019/01/08 Tyrosine kinase RET  Pyrazolo[3,4-d]pyrimidine  Anticancer  Cell proliferation  Structure-activity relationship   Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents 期刊论文  OAI收割 CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2017, 卷号: 33, 期号: 3, 页码: 365-372 作者:  Zhang Lan;  Deng Xinshan;  Wu Jiaofeng;  Meng Guangpeng;  Liu Congchong   |  收藏  |  浏览/下载：63/0  |  提交时间：2021/02/02 MOLECULAR TARGETED DRUGS  TYROSINE KINASE  CANCER-CELLS  EGFR  RESISTANCE  POTENT  DISCOVERY  NSCLC  Anticancer activity  Epidemal growth factor receptor(EGFR) inhibitor  N-( Furan-2-ylmethyl)-1H-indole3-carboxamide derivative