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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [7]
上海生物化学与细胞生... [1]
采集方式
OAI收割 [8]
内容类型
期刊论文 [8]
发表日期
2024 [1]
2018 [1]
2017 [1]
2012 [1]
2011 [1]
2009 [1]
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学科主题
Neuroscien... [1]
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Synthesis and biological evaluation of multimodal monoaminergic arylpiperazine derivatives with potential antidepressant profile
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 275, 页码: 16
作者:
Zheng, Jiefang
;
Zhou, Liping
;
Gong, Xudong
;
Yang, Feipu
;
Cheng, Jiaxin
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/08/22
Triple reuptake inhibitors
5-HT 1A R agonists
Antidepressants
Multimodal serotonergic compounds
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3117-3125
作者:
Liu, Wenwen
;
Wang, Huan
;
Li, Xiaokang
;
Xu, Yixiang
;
Zhang, Jian
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2019/01/08
Depression
Cognitive impairment
Multitarget-directed ligand
5-HT1A agonist
5-HT reuptake inhibition
ChE inhibition
Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation
期刊论文
OAI收割
ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 12, 页码: 2708-2721
作者:
Li, Xiaokang
;
Wang, Huan
;
Xu, Yixiang
;
Liu, Wenwen
;
Gong, Qi
  |  
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/01/08
Alzheimer's disease
depression
multitarget-directed ligand
ChE inhibition
5-HT1A agonist
5-HT reuptake inhibition
Design,synthesis and bioactivity of aryl piperazine benzo[b]oxazine derivatives
期刊论文
OAI收割
Acta Pharmaceutica Sinica, 2012, 卷号: 47, 期号: 6, 页码: 755-763
作者:
Zheng Yongyong
;
Xie Peng
;
Zhang Jin
;
Li Jianqi
;
Guo Lin
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
5-HT_(1A)
aryl piperazine benzo [b] oxazine derivatives
pharmacophore model
5-HT reuptake
5-HT_(1A)
Classification of 5-HT_(1A) receptor agonists and antagonists using GA-SVM method
期刊论文
OAI收割
Acta Pharmacologica Sinica, 2011, 卷号: 32, 期号: 11, 页码: 1424
作者:
Zhu Xuelian
;
Cai Haiyan
;
Xu Zhijian
;
Wang Yong
;
Wang Heyao
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
VIVO PHARMACOLOGICAL EVALUATION
SEROTONIN TRANSPORTER AFFINITY
IN-VITRO
DUAL 5-HT1A
REUPTAKE INHIBITORS
LIGANDS
POTENT
DERIVATIVES
DISCOVERY
ANALOGS
5-HT1A receptor
support vector machine
genetic algorithm
agonist
antagonists
Synthesis and biological activities of N-indolalkyl piperidine derivatives and their analogues
期刊论文
OAI收割
Chinese Journal of Medicinal Chemistry, 2009, 卷号: 19, 期号: 3, 页码: 161-169
作者:
WANG Guan
;
ZHANG Gui-sen
;
GUO Lin
;
YU Lei-ping
;
LI Jian-qi
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
N-indolalkyl piperidine derivatives
synthesis
5-HT reuptake inhibitors
5-HT_(2A) recepetor
non-opioid analgesic activity
Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models
期刊论文
OAI收割
NEUROPHARMACOLOGY, 2006, 卷号: 50, 期号: 8, 页码: 934-940
作者:
Xu, Lin-Feng
;
Chu, Wen-Jing
;
Qing, Xiao-Yun
;
Li, Sheng
;
Wang, Xue-Song
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
Dactylicapnos scandens Hutch
antidepressant
5-HT (5-hydroxytryptamine, serotonin)
noradrenaline (NE)
reuptake inhibitor
transporter
Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models
期刊论文
OAI收割
NEUROPHARMACOLOGY, 2006, 卷号: 50, 期号: 8, 页码: 934-940
作者:
Xu, LF
;
Chu, WJ
;
Qing, XY
;
Li, S
;
Wang, XS
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2015/07/22
Dactylicapnos scandens Hutch
antidepressant
5-HT (5-hydroxytryptamine
noradrenaline (NE)
reuptake inhibitor
transporter
serotonin)