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浏览/检索结果: 共82条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2025, 页码: 16 作者:  Tang, Cai-ling;  Li, Yuan-qing;  Du, Xi-kun;  Fang, Xiao-xia;  Guang, Yi-man   |  收藏  |  浏览/下载：10/0  |  提交时间：2025/04/01 dynamics simulation  CECR2  covalent inhibitor  allosteric effect   Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466 作者:  Li, Yang;  Fang, Yan;  Chen, Xiaoyu;  Tong, Linjiang;  Feng, Fang   |  收藏  |  浏览/下载：12/0  |  提交时间：2025/04/01 P21-activated kinase 4  Tetrahydrobenzofuro[2  3-c]pyridine  Structure-activity relationship  Allosteric inhibitor  Pharmacokinetics properties  Kinase selectivity  Pancreatic cancer  Immune infiltration   Identification of USP2 as a novel target to induce degradation of KRAS in myeloma cells 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 12, 页码: 5235-5248 作者:  Wang, Yingying;  Zhang, Youping;  Luo, Hao;  Wei, Wei;  Liu, Wanting   |  收藏  |  浏览/下载：14/0  |  提交时间：2025/04/01 Ubiquitin-specific protease 2  KRAS  Gambogic acid  Multiple myeloma  Degradation  Ubiquitination  Allosteric pocket  Deubiquitination   Molecular basis of enhanced GLP-1 signaling mediated by GLP-1(9-36) in conjunction with LSN3318839 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 11, 页码: 5069-5073 作者:  Li, Jie;  Li, Guanyi;  Mai, Yiting;  Liu, Xiao;  Yang, Dehua   |  收藏  |  浏览/下载：9/0  |  提交时间：2025/01/06 GLP-1(9-36)  Cryo-electron microscopy  Metabolite  Allosteric modulation   Allosteric Regulation and Inhibition of Coronavirus 3CLpro Revealed by HDX-MS 期刊论文  OAI收割 CHEMBIOCHEM, 2024, 卷号: 25, 期号: 13, 页码: 9 作者:  Song, Ning;  Zheng, Wen;  Song, Bin;  Zheng, Jie   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/08/20 coronavirus  3Clpro  allosteric inhibitor   From bench to bedside: current development and emerging trend of KRAS-targeted therapy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18 作者:  Chen, Yi;  Liu, Qiu-pei;  Xie, Hua;  Ding, Jian   |  收藏  |  浏览/下载：55/0  |  提交时间：2024/01/16 KRAS mutation  KRAS(G12C) inhibitor  Pan-KRAS inhibitor  SHP2 allosteric inhibitor  SOS1 inhibitor  combination therapy   The Molecular Basis of Catalysis by SDR Family Members Ketoacyl-ACP Reductase FabG and Enoyl-ACP Reductase FabI in Type-II Fatty Acid Biosynthesis 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 页码: 12 作者:  Zhou, Jiashen;  Zhang, Lin;  Wang, Yiran;  Song, Wenyan;  Huang, Yuzhou   |  收藏  |  浏览/下载：47/0  |  提交时间：2023/12/08 Acyl-ACP Reductases  Allosteric Regulation  Biosynthesis  Enantioselective Reduction  Enzyme Catalysis   Elastic network models and molecular dynamic simulations reveal the molecular basis of allosteric regulation in ubiquitin-specific protease 7 (USP7) 期刊论文  OAI收割 COMPUTERS IN BIOLOGY AND MEDICINE, 2023, 卷号: 162, 页码: 10 作者:  Xu, Jing;  Wang, Yiran;  Zhang, Jiali;  Abdelmoneim, Amr Abbas;  Liang, Zhongjie   |  收藏  |  浏览/下载：30/0  |  提交时间：2023/10/17 USP7  Allosteric regulation  Elastic network models  Molecular dynamics simulations   A RhoA structure with switch II flipped outward revealed the conformational dynamics of switch II region 期刊论文  OAI收割 JOURNAL OF STRUCTURAL BIOLOGY, 2023, 卷号: 215, 期号: 2, 页码: 107942 作者:  Jiang, Hao;  Zu, Shijia;  Lu, Yu;  Sun, Zhongya;  Adeerjiang, Akejiang   |  收藏  |  浏览/下载：25/0  |  提交时间：2024/03/27 Small GTPases  Crystal structures of RhoA  Dynamics of switch II  Molecular dynamics simulations  Allosteric pocket   Oligosaccharide Blocks PAR1 (Proteinase-Activated Receptor 1)-PAR4-Mediated Platelet Activation by Binding to Thrombin Exosite II and Impairs Thrombosis 期刊论文  OAI收割 ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2023, 卷号: 43, 期号: 2, 页码: 253-266 作者:  Li,Sujuan;  Wang,Weili;  Lin,Lisha;  Yang,Lian;  Cai,Ying   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/05/09 oligosaccharide  platelet activation  receptor  protease-activated  thrombin thrombosis  ANTIPLATELET THERAPIES  ALLOSTERIC LINKAGE  TISSUE FACTOR  PROTEASE  VORAPAXAR  MECHANISM  REVEALS  SITE