中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [251]
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期刊论文 [1721]
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共1764条,第1-10条
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Transcription factor occupancy limits DNA methylation and determines ICAM1 expression in breast cancer
期刊论文
OAI收割
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2025, 卷号: 57, 期号: 5, 页码: 818-833
作者:
Chen, Mingcang
;
Zhou, Ying
;
Fu, Zhengwei
;
Wu, Chunyu
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
intercellular adhesion molecule 1
competition
DNA methylation
transcription factor binding
breast cancer
Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Characterization of the specific proteins to which HH-A, a drug that alleviates ischemic brain injury, binds in rat plasma
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2025, 卷号: 53, 期号: 7, 页码: 15
作者:
Zhao, Jie
;
Zheng, Yuandong
;
Lei, Peng
;
Zhang, Yuying
;
Zhang, Pingping
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Stroke
Covalent binding
HH-A
Ischemic brain injury
Proteomics
Design, synthesis and bio-evaluation of 2,5-disubstituted thiazole derivatives for potential treatment of acute myeloid leukemia through targeting CDK9
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 160, 页码: 16
作者:
Chen, Sumeng
;
Huang, Jindi
;
Zhang, Shipeng
;
Zheng, Xinni
;
Chen, Hongming
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2025/06/23
CDK9
Inhibitor
Acute myeloid leukemia
Binding mode
Cellular mechanism
SQSTM1/p62 Orchestrates Skin Aging via USP7 Degradation
期刊论文
OAI收割
AGING CELL, 2025, 页码: 16
作者:
Chen, Liu
;
Wang, Xiaoping
;
Wang, Yuchen
;
Yao, Qingxin
;
Liu, Yunyao
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/06/23
binding interaction
skin aging
SQSTM1/p62
USP7
Targeting Two Odorant-Binding Proteins in Acyrthosiphon pisum: Discovery of Novel Jasmone Derivatives as Aphid Repellents
期刊论文
OAI收割
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2025, 卷号: 73, 期号: 19, 页码: 11998-12013
作者:
Zhu, Ziwei
;
Li, Huilin
;
Zhu, Wenya
;
Du, Shaoqing
;
Yang, Zhaokai
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/06/23
odorant-binding proteins
jasmone derivatives
rational design
aphid repellents
insect behaviorregulators
The effect of cations and metakaolin on chloride binding properties of mortars using simulated desalinated sea sand
期刊论文
OAI收割
ADVANCES IN CEMENT RESEARCH, 2025, 页码: 10
作者:
Sun, Congtao
;
Geng, Yuanjie
;
Zhang, Yuguo
;
Sun, Ming
;
Lu, Yihui
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/07/11
AFm phases
cations
chloride
chloride binding
C-S-H
metakaolin
simulated desalinated sea sand
Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods
期刊论文
OAI收割
MOLECULAR DIVERSITY, 2025, 页码: 14
作者:
Wen, Yiming
;
Xu, Peijia
;
Chen, Yijie
;
Meng, Jingyi
;
Zheng, Mingyue
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2025/04/01
p53 Y220C
Covalent stabilizer
Virtual screening
Molecular dynamics
DNA binding
Structure-activity relationship
Cancer therapy
DeepFusion: A deep bimodal information fusion network for unraveling protein-RNA interactions using in vivo RNA structures
期刊论文
OAI收割
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2024, 卷号: 23, 页码: 617-625
作者:
Qiao, Yixuan
;
Yang, Rui
;
Liu, Yang
;
Chen, Jiaxin
;
Zhao, Lianhe
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/05/20
Information fusion
Deep learning
RNA -binding proteins
In vivo RNA structures
Motifs
Interaction-Based Inductive Bias in Graph Neural Networks: Enhancing Protein-Ligand Binding Affinity Predictions From 3D Structures
期刊论文
OAI收割
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE, 2024, 卷号: 46, 期号: 12, 页码: 8191-8208
作者:
Yang, Ziduo
;
Zhong, Weihe
;
Lv, Qiujie
;
Dong, Tiejun
;
Chen, Guanxing
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2025/01/14
Proteins
Programmable logic arrays
Three-dimensional displays
Predictive models
Graph neural networks
Data models
Convolution
Protein-ligand binding affinity
graph neural networks
inductive bias
drug-target interaction
structure-based virtual screening