中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [5]
海洋研究所 [3]
昆明植物研究所 [2]
福建物质结构研究所 [1]
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期刊论文 [15]
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Design and synthesis of novel benzimidazole-iminosugars linked a substituted phenyl group and their inhibitory activities against beta-glucosidase
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2022, 卷号: 127, 页码: 6
作者:
Liu, Xu
;
Li, Fengxin
;
Su, Lulu
;
Wang, Mingchen
;
Jia, Tongguan
  |  
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2022/08/30
Benzimidazole-iminosugars
Glucosidase inhibitors
Suzuki coupling reaction
Inhibition type
Solvent-exposed region
Bitter Melon and Diabetes Mellitus
期刊论文
OAI收割
FOOD REVIEWS INTERNATIONAL, 2021
作者:
Gao,Ya
;
Li,Xian
;
Huang,Yanjie
;
Chen,Jianchao
;
Qiu,Minghua
  |  
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2022/04/02
Bitter melon
diabetes mellitus
crude extracts
phyto-metabolites
hypoglycemic mechanism
MOMORDICA-CHARANTIA L.
11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1
ALPHA-GLUCOSIDASE INHIBITION
INSULIN-RESISTANCE
ANTIDIABETIC ACTIVITIES
GUT MICROBIOTA
STRUCTURAL-CHARACTERIZATION
PHENOLIC-COMPOUNDS
OXIDATIVE STRESS
PROTEIN-KINASE
Per- and polyfluoroalkyl substances display structure-dependent inhibition towards UDP-glucuronosyltransferases
期刊论文
OAI收割
ENVIRONMENTAL POLLUTION, 2019, 卷号: 254, 页码: -
作者:
Liu, Yong-Zhe
;
Zhang, Zhi-Peng
;
Fu, Zhi-Wei
;
Yang, Kun
;
Ding, Ning
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2020/09/10
Per- and polyfluoroalkyl substances (PFASs)
UDP-Glucuronosyltransferases (UGTs)
Half inhibition concentration (IC50)
Inhibition type
Inhibition kinetic parameters (Ki)
In vitro-in vivo extrapolation (IVIVE)
Bioactive triterpenoid glycosides from the twigs and leaves of Camellia reticulata
期刊论文
OAI收割
PHYTOCHEMISTRY LETTERS, 2018, 卷号: 25, 页码: 6-11
作者:
Chen, Qi-Run
;
Li, Dan
;
Qin, Xu-Jie
;
Liu, Hui
;
Ni, Wei
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2018/07/16
Camellia Reticulata
Oleanane-type Glycosides
Dianshanchaosides A-d
Nitric Oxide Inhibition
Cytotoxicity
Design, synthesis and biological evaluation of uncharged catechol derivatives as selective inhibitors of PTP1B
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 136, 页码: 348-359
作者:
Li, Xiang-Qian
;
Xu, Qi
;
Luo, Jiao
;
Wang, Li-Jun
;
Jiang, Bo
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2017/10/09
Type 2 Diabetes
Ptp1b Inhibition
Selectivity
Competitive
Cellular Activity
Phragmalin-type limonoids with NF-kappa B inhibition from Chukrasia tabularis var. velutina
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 16, 页码: 3791-3796
作者:
Zhang, Feng
;
Zhang, Chuan-Rui
;
Tao, Xia
;
Wang, Jun
;
Chen, Wan-Sheng
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Chukrasia tabularis var. velutina
Phragmalin-type limonoids
NF-kappa B inhibition
mg132aproteasomeinhibitorenhancesldluptakeinhepg2cellsinvitrobyregulatingldlrandpcsk9expression
期刊论文
OAI收割
actapharmacologicasinica, 2014, 卷号: 35, 期号: 8, 页码: 994
作者:
Yan Hong
;
Ma Yanling
;
Gui Yuzhou
;
Wang Shumei
;
Wang Xinbo
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
PROTEIN-KINASE-C
SUBTILISIN/KEXIN TYPE 9
RECEPTOR
CHOLESTEROL
PATHWAY
ELEMENT
GENE
TRANSCRIPTION
EPSILON
TARGET
cholesterol homeostasis
LDLR
MG132
proteasome inhibition
PKC
PCSK9
pravastatin
HepG2
cells
DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION OF 2,5-DIPHENYL-1,3,4-OXADIAZOLE DERIVATIVES AS NOVEL INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE
期刊论文
OAI收割
HETEROCYCLES, 2012, 卷号: 85, 期号: 11, 页码: 2693-2712
作者:
He, Hai-Bing
;
Gao, Li-Xin
;
Zhou, Yue-Yang
;
Liu, Ting
;
Tang, Jie
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Fructose-1,6-bisphosphatase
2,5-Phenyl-1,3,4-oxadiazole
Type-2 Diabetes
Enzyme Inhibition
Regulation of Glucose Oxidase Activity through Interaction with Fullerene Derivatives
期刊论文
OAI收割
CHINESE JOURNAL OF CHEMISTRY, 2012, 卷号: 30, 期号: 2, 页码: 418-426
作者:
Gao Yunyan
;
Wang Zhongli
;
Ou Zhize
;
Li Yi
;
Wang Xuesong
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/04/09
Fullerene C60
Glucose Oxidase
Partial Mixed-type Inhibition Mechanism
Redox Mediator
Electron Transfer
Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
期刊论文
OAI收割
Chinese Journal of Structural Chemistry, 2009, 卷号: 28, 期号: 2, 页码: 253-259
L. G. Jiang, G. X. Zhao, C. B. Bian, C. Yuan, Z. X. Huang and M. D. Huang
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2012/11/06
urokinase-type plasminogen activator
4-(aminomethyl)benzoic acid
(4-aminomethyl-phenyl)-methanol
enzyme inhibition assays
contact area
catalytic domain
inhibitors
system
subsite