机构

• 上海药物研究所 [45]
• 合肥物质科学研究院 [9]
• 金属研究所 [7]
• 昆明植物研究所 [4]
• 长春应用化学研究所 [2]
• 新疆理化技术研究所 [1]
• 更多

采集方式

• OAI收割 [74]

内容类型

• 期刊论文 [74]

发表日期

• 2024 [2]
• 2022 [2]
• 2021 [4]
• 2020 [6]
• 2019 [3]
• 2018 [2]
• 更多

学科主题

• Pharmacolo... [6]
• Chemistry [5]
• Biochemist... [3]
• Biochemist... [1]
• Biophysics [1]
• Chemistry,... [1]
• 更多

筛选

浏览/检索结果: 共74条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Structure-based development of potent and selective type-II kinase inhibitors of RIPK1 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334 作者:  Qin, Ying;  Li, Dekang;  Qi, Chunting;  Xiang, Huaijiang;  Meng, Huyan   |  收藏  |  浏览/下载：23/0  |  提交时间：2024/03/06 RIPK1  Necroptosis  Type-II kinase inhibitors  Rational design  Lead optimization  Structure-activity relationship  Anti-inflammation  Preclinical drug discovery   KinomeMETA: meta-learning enhanced kinome-wide polypharmacology profiling 期刊论文  OAI收割 BRIEFINGS IN BIOINFORMATICS, 2024, 卷号: 25, 期号: 1, 页码: 15 作者:  Ren, Qun;  Qu, Ning;  Sun, Jingjing;  Zhou, Jingyi;  Liu, Jin   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/05/07 kinome profiling  kinase inhibitors  polypharmacology  deep learning  meta-learning   Baseline anemia predicts a poor prognosis in patients with non-small cell lung cancer with epidermal growth factor receptor mutations: a retrospective study 期刊论文  OAI收割 BMC PULMONARY MEDICINE, 2022, 卷号: 22 作者:  Wei, Jingwen;  Xiang, Jing;  Hao, Yue;  Si, Jinfei;  Wang, Wenxian   |  收藏  |  浏览/下载：41/0  |  提交时间：2022/12/22 Anemia  Epidermal growth factor receptor  Epidermal growth factor receptor tyrosine kinase inhibitors  Non-small cell lung cancer   Efficacy and safety of anlotinib with and without EGFR-TKIs or immunotherapy in the treatment of elder patients with non-small-cell lung cancer: a retrospective study 期刊论文  OAI收割 BMC PULMONARY MEDICINE, 2022, 卷号: 22 作者:  Wang, Wenxian;  Shao, Lan;  Xu, Yibing;  Song, Zhengbo;  Lou, Guangyuan   |  收藏  |  浏览/下载：44/0  |  提交时间：2022/12/23 Non-small cell lung cancer  Prognosis  Angiogenesis  Tyrosine kinase inhibitors   Design and Synthesis of Alkyl Phenols Inhibitors of Death Associated Apoptotic Protein Kinase 2 (DRAK2) 期刊论文  OAI收割 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3204-3213 作者:  Zheng Zhang;  Dai Chengqiu;  Wu Honghong;  Li Jingya;  Nan Fajun   |  收藏  |  浏览/下载：34/0  |  提交时间：2021/11/04 death associated apoptotic protein kinase 2  diabetes  alkylphenols  inhibitors   The genomic landscape of young and old lung cancer patients highlights age-dependent mutation frequencies and clinical actionability in young patients 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF CANCER, 2021 作者:  Cai, Lei;  Chen, Yong;  Tong, Xiaoling;  Wu, Xue;  Bao, Hua   |  收藏  |  浏览/下载：89/0  |  提交时间：2021/06/15 EGFR  ERBB2  gene fusions  tyrosine kinase inhibitors  young lung cancer patients   Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794 作者:  Wu, Xiaowei;  Dai, Mengdi;  Cui, Rongrong;  Wang, Yulan;  Li, Chunpu   |  收藏  |  浏览/下载：51/0  |  提交时间：2021/05/24 Tyrosine kinase  Covalent FGFR inhibitors  Virtual screening  Pyrazolo[3,4-d] pyridazinone  Structure-activity relationships  Antitumor efficacy   Treatment and Prognosis of Solid and Cystic Brain Metastases in Patients with Non-Small-Cell Lung Cancer 期刊论文  OAI收割 CANCER MANAGEMENT AND RESEARCH, 2021, 卷号: 13 作者:  Xu, Yi-Bing;  Zhang, Yiping;  Song, Zhengbo;  Wang, Wenxian;  Shao, Lan   |  收藏  |  浏览/下载：39/0  |  提交时间：2021/09/06 cystic brain metastases  tyrosine kinase inhibitors  chemotherapy  radiation therapy  lung cancer   Characterization of covalent binding of tyrosine kinase inhibitors to plasma proteins 期刊论文  OAI收割 DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 35, 期号: 5, 页码: 456-465 作者:  Liu, Xiaoyun;  Feng, Dan;  Zheng, Mingyue;  Cui, Yongmei;  Zhong, Dafang   |  收藏  |  浏览/下载：45/0  |  提交时间：2020/12/21 Covalent tyrosine kinase inhibitors  Covalent binding  Human serum albumin  Molecular docking  Quantitative calculations  Linear modeling  Species difference   Emerging roles of class I PI3K inhibitors in modulating tumor microenvironment and immunity 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8 作者:  Sun, Pu;  Meng, Ling-hua   |  收藏  |  浏览/下载：33/0  |  提交时间：2020/12/21 phosphoinositide 3-kinase (PI3K)  PI3K inhibitors  tumor microenvironment  immune cells  immunotherapy