中国科学院机构知识库网格系统: 检索

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	targetingthepi3kaktmtorsignalingpathwaybypterostilbeneattenuatesmantlecelllymphomaprogression 期刊论文 OAI收割 actabiochimicaetbiophysicasinica, 2018, 卷号: 50, 期号: 8, 页码: 782 作者: Yu Dandan; Zhang Yong; Chen Gege; Xie Yongsheng; Xu Zhijian \| 收藏 \| 浏览/下载：32/0 \| 提交时间：2020/07/01 PROTEIN-KINASE PATHWAY CANCER IN-VITRO TRANSDUCTION PATHWAYS CYCLE ARREST APOPTOSIS ACTIVATION PATHOGENESIS INHIBITION ANTICANCER EXPRESSION mantle cell lymphoma pterostilbene antiproliferative activity PI3K/Akt/mTOR pathway synergistic cytotoxicity
	Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer 期刊论文 OAI收割 ONCOTARGET, 2016, 卷号: 7, 期号: 41, 页码: 67071-67086 作者: Qian, Jianchang; Chen, Yaqing; Meng, Tao; Ma, Lanping; Meng, Lanfang \| 收藏 \| 浏览/下载：47/0 \| 提交时间：2019/01/08 mTOR kinase inhibitor mTORC2 apoptosis lipid metabolism
	Role of autophagy in the pathogenesis of multiple sclerosis 期刊论文 OAI收割 NEUROSCIENCE BULLETIN, 2015, 卷号: 31, 期号: 4, 页码: 435-444 作者: Liang, PZ; Le, WD 收藏 \| 浏览/下载：29/0 \| 提交时间：2015/12/30 EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS CENTRAL-NERVOUS-SYSTEM ANTIGEN-PRESENTING CELLS FOCAL CEREBRAL-ISCHEMIA T-CELLS MTOR KINASE GENE ATG5 NEURODEGENERATIVE DISEASE IL-1-BETA PRODUCTION AXON REGENERATION
	23benzoylthioureido4567tetrahydrobenzobthiophene3carboxylicacidamelioratesmetabolicdisordersinhighfatdietfedmice 期刊论文 OAI收割 actapharmacologicasinica, 2015, 卷号: 36, 期号: 4, 页码: 483 作者: Zhang Jin; Zhang Lina; Chen Dongmei; Fu Yanyun; Zhang Feng \| 收藏 \| 浏览/下载：25/0 \| 提交时间：2020/07/01 ACTIVATED PROTEIN-KINASE ELEMENT-BINDING PROTEIN-1C INSULIN-RESISTANCE LIVER-DISEASE TRANSCRIPTION FACTOR DIABETES-MELLITUS HEPATIC STEATOSIS CULTURED-CELLS SREBP ACTIVITY DIRECT TARGET 2-(3-benzoylthioureido)-4,5,6,7-tetrahydrobenzob thiophene-3-carboxylic acid lipogenesis SREBP-1c AMPK mTOR hepatic lipid accumulation obesity metabolic disorders
	HSP90 inhibitor AUY922 abrogates up-regulation of RTKs by mTOR inhibitor AZD8055 and potentiates its antiproliferative activity in human breast cancer 期刊论文 OAI收割 INTERNATIONAL JOURNAL OF CANCER, 2014, 卷号: 135, 期号: 10, 页码: 2462-2474 作者: Chen, Si-Meng; Guo, Chen-Liang; Shi, Jia-Jie; Xu, Yi-Chao; Chen, Yi \| 收藏 \| 浏览/下载：30/0 \| 提交时间：2019/01/08 mTOR kinase inhibitor HSP90 inhibitor breast cancer receptor tyrosine kinases drug combination
	Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73 期刊论文 OAI收割 ONCOTARGET, 2014, 卷号: 5, 期号: 17, 页码: 7691-7704 作者: Lam, Frankie; Abbas, Abdullahi Y.; Shao, Hao; Teo, Theodosia; Adams, Julian \| 收藏 \| 浏览/下载：45/0 \| 提交时间：2019/01/08 CDK9 shRNA Mnks eIF4E kinase inhibitors PI3K/Akt/mTOR Ras/Raf/MAPK Flavopiridol CGP57380 apoptosis transcription translation drug development
	Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif 期刊论文 OAI收割 FASEB JOURNAL, 2013, 卷号: 27, 期号: 1, 页码: 42006 作者: Ding, JP; Wang, JC; Zhong, C; Wang, F 收藏 \| 浏览/下载：21/0 \| 提交时间：2015/07/22 activation loop hydrophobic motif mammalian target of rapamycin (mTOR) signalling phosphorylation ribosomal protein subunit 6 kinase 1 (S6K1) zinc finger
	Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor of mTOR 期刊论文 OAI收割 BIOCHEMICAL PHARMACOLOGY, 2012, 卷号: 83, 期号: 9, 页码: 1183-1194 作者: Chen, Si-meng; Liu, Jia-li; Wang, Xiang; Liang, Chris; Ding, Jian \| 收藏 \| 浏览/下载：26/0 \| 提交时间：2019/01/08 X-387 mTOR kinase Cancer therapy Cell migration Autophagy
	Novel indole alpha-methylene-gamma-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases 期刊论文 OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 卷号: 15, 期号: 21, 页码: 4799-4802 作者: Ding, HS; Zhang, C; Wu, XH; Yang, CH; Zhang, XW \| 收藏 \| 浏览/下载：15/0 \| 提交时间：2019/01/08 indole alpha-methylene-gamma-lactones AKT-mTOR signaling pathway kinase inhibitors