中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [15]
大连化学物理研究所 [2]
过程工程研究所 [2]
金属研究所 [1]
长春应用化学研究所 [1]
采集方式
OAI收割 [21]
内容类型
期刊论文 [21]
发表日期
2023 [2]
2022 [2]
2021 [1]
2019 [1]
2014 [4]
2013 [3]
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学科主题
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Enhancing the oral bioavailability of poorly water-soluble amisupiride with solid nanodispersion
期刊论文
OAI收割
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2023, 卷号: 86, 页码: 6
作者:
Zhang, Xinyue
;
Li, Jie
;
Rong, Rong
;
Wang, Dangge
;
Wang, Donghai
  |  
收藏
  |  
浏览/下载:107/0
  |  
提交时间:2023/10/17
Solid dispersion
Oral bioavailability
Amisupiride
Nanoparticle
Poorly water-soluble drugs
Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 253, 页码: 16
作者:
He, Yulong
;
Li, Shunyi
;
Zhu, Yueyue
;
Wang, Yujie
;
Chen, Yuqi
  |  
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2023/10/17
Structure-activity relationship
FABP4 inhibitor
Biphenyl scaffold
Selectivity
Oral bioavailability
Anti-inflammation
Advances in oral peptide drug nanoparticles for diabetes mellitus treatment
期刊论文
OAI收割
BIOACTIVE MATERIALS, 2022, 卷号: 15, 页码: 392-408
作者:
Li, Yan
;
Zhang, Wen
;
Zhao, Ruichen
;
Zhang, Xin
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2022/06/15
Oral nanoparticles
Peptide drugs
Gastrointestinal tract
Diabetes mellitus
Oral bioavailability
Poly(maleic anhydride-alt-1-octadecene)-based bioadhesive nanovehicles improve oral bioavailability of poor water-soluble gefitinib
期刊论文
OAI收割
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2022, 卷号: 48, 期号: 3, 页码: 109-116
作者:
Wang, Guanru
;
Xie, Yaru
;
Qian, Xindi
;
Zhang, Xinyue
;
Shan, Yanqiang
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2024/03/21
Gefitinib
nanovehicle
oral bioavailability
poorly water soluble drugs
bioadhesive
Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia
期刊论文
OAI收割
CHEMMEDCHEM, 2021, 页码: 12
作者:
Jin, Tingting
;
Wang, Peipei
;
Long, Xiubing
;
Jiang, Kailong
;
Song, Pinrao
  |  
收藏
  |  
浏览/下载:134/0
  |  
提交时间:2021/05/24
CHK1 inhibitor
diaminopyrimidine
DNA damage response
oral bioavailability
Supersaturated polymeric micelles for oral silybin delivery: the role of the Soluplus-PVPVA complex
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 1, 页码: 107-117
作者:
Zhu, Chunliu
;
Gong, Shuang
;
Ding, Jinsong
;
Yu, Miaorong
;
Ahmad, Ejaj
  |  
收藏
  |  
浏览/下载:106/0
  |  
提交时间:2020/07/01
Silybin
Soluplus
PVPVA
Complex
Supersaturated drug delivery system
Oral bioavailability
(R)-3-Amino-1-((3aS,7aS)-octahydro-1H-indol-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one derivatives as potent inhibitors of dipeptidyl peptidase-4: Design, synthesis, biological evaluation, and molecular modeling
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 23, 页码: 6684-6693
作者:
Wang, Sinan
;
Su, Mingbo
;
Wang, Jiang
;
Li, Zeng
;
Zhang, Lei
  |  
收藏
  |  
浏览/下载:111/0
  |  
提交时间:2019/01/08
DPP-4
Type 2 diabetes
Inhibitor
Binding mode
Oral bioavailability
Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 86, 页码: 242-256
作者:
Ji, Xun
;
Xia, Chunmei
;
Wang, Jiang
;
Su, Mingbo
;
Zhang, Lei
  |  
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2019/01/08
DPP4 inhibitors
GLP-1
Selectivity
Oral bioavailability
Oral glucose tolerance tests
hERG
PLGA-lipid liposphere as a promising platform for oral delivery of proteins
期刊论文
OAI收割
COLLOIDS AND SURFACES B-BIOINTERFACES, 2014, 卷号: 117, 期号: 1, 页码: 512-519
作者:
Ma, Tongtong
;
Wang, Lianyan
;
TingyuanYang
;
Wang, Dong
;
Ma, Guanghui
收藏
  |  
浏览/下载:104/0
  |  
提交时间:2014/08/28
Lipospheres
Uniform
Oral bioavailability
Proteins
Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 75, 页码: 111-122
作者:
Ji, Xun
;
Su, Mingbo
;
Wang, Jiang
;
Deng, Guanghui
;
Deng, Sisi
  |  
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2019/01/08
DPP4 inhibitors
Selectivity
Reversible kinetic characterization
Oral bioavailability
Oral glucose tolerance test