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• 上海药物研究所 [43]
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浏览/检索结果: 共66条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Drug discovery targeting thyroid hormone receptor f3 (THRf3) for the treatment of liver diseases and other medical indications 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 35-51 作者:  Wang, Kean;  Chen, Feiyang;  Wang, Jiang;  Liu, Hong   |  收藏  |  浏览/下载：10/0  |  提交时间：2025/04/01 Thyroid hormone  Thyroid hormone /3 receptor  MASLD  MASH  THR/3 agonist   The antidepressant-like effect and proposed mechanism of action of TPN672MA, a novel serotonin-dopamine receptor modulator for the treatment of schizophrenia 期刊论文  OAI收割 PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2024, 卷号: 242, 页码: 13 作者:  Cheng, Jiaxin;  Wu, Chunhui;  Wang, Yu;  Wang, Zhen;  He, Yang   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/09/24 TPN672MA  5-HT 1A receptor agonist  D 2 /D 3 receptor partial agonist  5-HT 2A receptor antagonist  Antidepressant-like  Mechanism   Structural basis for activation of somatostatin receptor 5 by cyclic neuropeptide agonists 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 卷号: 121, 期号: 26, 页码: 10 作者:  Li, Jingru;  You, Chongzhao;  Li, Yang;  Li, Changyao;  Fan, Wenjia   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/08/22 SSTR5  peptide agonists  agonist selectivity  receptor activation   A novel approach to exploit Small-Molecule glucagon-like Peptide-1 receptor agonists with high potency 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 107, 页码: 19 作者:  Wang, Xiaoyan;  Yun, Ying;  Chen, Lili;  Guo, Shimeng;  Niu, Buying   |  收藏  |  浏览/下载：33/0  |  提交时间：2024/07/12 Diabetes  GLP-1 receptor  Agonist  Structural optimization  Water molecule replacement  Structure activity relationship  Docking simulation   Design, Synthesis and Bioactivity of NYX-2925 L-Proline Derivatives as N-Methyl-D-aspartate (NMDA) Receptor Partial Agonists 期刊论文  OAI收割 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2024, 卷号: 44, 期号: 4, 页码: 1247-1263 作者:  Wu Youjin;  Jin Zhengsheng;  Liu Yongjia;  Huang Wenqian;  Zhao Guilong   |  收藏  |  浏览/下载：4/0  |  提交时间：2024/08/22 N-methyl-D-aspartate (NMDA) receptor  partial agonist  NYX-2925  synthesis  bioactivity   Application of ensemble learning for predicting GABAA receptor agonists 期刊论文  OAI收割 COMPUTERS IN BIOLOGY AND MEDICINE, 2024, 卷号: 169, 页码: 13 作者:  Xiao, Fu;  Ding, Xiaoyu;  Shi, Yan;  Wang, Dingyan;  Wang, Yitian   |  收藏  |  浏览/下载：34/0  |  提交时间：2024/03/25 GABA(A )receptor  Benzodiazepine  Agonist  Machine learning  Classification   Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13 作者:  Darbalaei, Sanaz;  Chang, Ru-lue;  Zhou, Qing-tong;  Chen, Yan;  Dai, An-tao   |  收藏  |  浏览/下载：33/0  |  提交时间：2022/09/30 glucagon-like peptide-1 receptor  glucagon receptor  dual and triple agonist  cAMP  pERK1/2  unimolecular polypharmacology   Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists 期刊论文  OAI收割 PHARMACEUTICALS, 2022, 卷号: 15 作者:  Sun, Lei;  Zheng, Zhi-Ming;  Shao, Chang-Sheng;  Zhang, Zhi-Yong;  Li, Ming-Wei   |  收藏  |  浏览/下载：27/0  |  提交时间：2022/12/22 glucagon-like peptide-1  GLP-1 receptor agonist  functional protein design  molecular dynamics simulation  long-acting antihyperglycemic   Farnesoid X receptor (FXR) agonists induce hepatocellular apoptosis and impair hepatic functions via FXR/SHP pathway 期刊论文  OAI收割 ARCHIVES OF TOXICOLOGY, 2022, 页码: 15 作者:  Zhang, Tianwei;  Feng, Shanshan;  Li, Jiahuan;  Wu, Zhitao;  Deng, Qiangqiang   |  收藏  |  浏览/下载：61/0  |  提交时间：2022/06/15 FXR agonist  Hepatotoxicity  Farnesoid X receptor  Obeticholic acid  Px-102  Apoptosis   Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RAR alpha-PPAR gamma-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice 期刊论文  OAI收割 NUTRIENTS, 2022, 卷号: 14, 期号: 12, 页码: 2411 作者:  Zhao, Zhuohui;  Deng, Zhen-Tao;  Huang, Suling;  Ning, Mengmeng;  Feng, Ying   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/04/30 Alisol B  non-alcoholic steatohepatitis  RAR alpha  CD36  FATTY LIVER  HEPATIC STEATOSIS  RECEPTOR  ORIENTALE  LIPOPROTEINS  23-ACETATE  AGONIST  CD36