机构

• 上海药物研究所 [13]
• 上海生物化学与细胞生... [1]

采集方式

• OAI收割 [14]

内容类型

• 期刊论文 [14]

发表日期

• 2025 [1]
• 2024 [2]
• 2023 [1]
• 2021 [1]
• 2020 [2]
• 2018 [2]
• 更多

学科主题

筛选

浏览/检索结果: 共14条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Synthesis, fluorescence properties of novel thiazolo[3,2-b][1,2,4]triazol derivatives as potent SHP2 inhibitors and its uses in sensing for Fe3+and cell imaging 期刊论文  OAI收割 JOURNAL OF MOLECULAR STRUCTURE, 2025, 卷号: 1324, 页码: 12 作者:  Yan, Xue;  Zhang, Chun;  Gao, Li-Xin;  Cao, Zi-Tong;  Gan, Su-Ya   |  收藏  |  浏览/下载：11/0  |  提交时间：2025/01/14 Thiazolo[3,2-b][1,2,4]triazole  Salicylic acid  Fe3+ion  Fluorescence property  SHP2   SHP2-Triggered Endothelial Cell Activation Fuels Estradiol-Independent Endometrial Sterile Inflammation 期刊论文  OAI收割 ADVANCED SCIENCE, 2024, 页码: 22 作者:  Pan, Jie;  Qu, Jiao;  Fang, Wen;  Zhao, Lixin;  Zheng, Wei   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/10/21 cell-cell interaction  endometrial hyperplasia  endothelial cell activation  SHP2-RIPK1-AP-1 axis  sterile inflammation   Novel imidazo[1,2,4] triazole derivatives: Synthesis, fluorescence, bioactivity for SHP1 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 15 作者:  Yan, Xue;  Zhang, Chun;  Gao, Li-Xin;  Liu, Min -Min;  Yang, Yu-Ting   |  收藏  |  浏览/下载：22/0  |  提交时间：2024/02/27 Imidazo[124] triazole derivatives  Fluorescence property  SHP1  Bioactivity  Cellular imaging   From bench to bedside: current development and emerging trend of KRAS-targeted therapy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18 作者:  Chen, Yi;  Liu, Qiu-pei;  Xie, Hua;  Ding, Jian   |  收藏  |  浏览/下载：55/0  |  提交时间：2024/01/16 KRAS mutation  KRAS(G12C) inhibitor  Pan-KRAS inhibitor  SHP2 allosteric inhibitor  SOS1 inhibitor  combination therapy   Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1) 期刊论文  OAI收割 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105 作者:  Yu Lijie;  Feng Bo;  Wang Zhijia;  Gao Lixin;  Zhang Chun   |  收藏  |  浏览/下载：112/0  |  提交时间：2021/11/04 5-phenyl-1,3,4-thiadiazole derivatives  Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)  inhibitors  structure-activity relationships   Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels 期刊论文  OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856 作者:  Liu, Wen;  Yin, Ye;  Wang, Meijing;  Fan, Ting;  Zhu, Yuyu   |  收藏  |  浏览/下载：101/0  |  提交时间：2020/12/24 Src homology 2 domain containing tyrosine phosphatase-2 (SHP2)  hepatic steatosis  insulin resistance  caspase-1  interleukin 18 (IL-18)  fatty liver  metabolic disorder  inflammation  cytokine signaling  caspase 1 (CASP1)  tyrosine-protein phosphatase (tyrosine phosphatase)  macrophage   Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 11, 页码: 5 作者:  Satheeshkumar, Rajendran;  Zhu, Rui;  Feng, Bo;  Huang, Chao   |  收藏  |  浏览/下载：54/0  |  提交时间：2020/07/01 Heterocyclic bis-aryl amides  PTP1B  SHP2  Inhibitors  Structure-activity relationships (SAR)   The HNF1 alpha-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1 期刊论文  OAI收割 MOLECULAR CANCER, 2018, 卷号: 17 作者:  Ding, Chen-Hong;  Yin, Chuan;  Chen, Shi-Jie;  Wen, Liang-Zhi;  Ding, Kai   |  收藏  |  浏览/下载：35/0  |  提交时间：2019/01/08 HNF1 alpha  HNF1A-AS1  Hepatocellular carcinoma  SHP-1  phosphatase activity   The E3 ligases Itch and WWP2 cooperate to limit T(H)2 differentiation by enhancing signaling through the TCR 期刊论文  OAI收割 NATURE IMMUNOLOGY, 2018, 卷号: 19, 期号: 7, 页码: 766-+ 作者:  Aki, Daisuke;  Li, Hui;  Zhang, Wen;  Zheng, Mingke;  Liu, Yun-Cai   |  收藏  |  浏览/下载：95/0  |  提交时间：2019/04/28 Cd4(+) T-cells  Ubiquitin Ligases  Immune-response  Moth-eaten  Cbl-b  Activation  Protein  Degradation  Shp-1  Ubiquitylation   Benzo[c][1,2,5] thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5154-5157 作者:  Wang, Wen-Long;  Chen, Xiao-Yu;  Gao, Ya;  Gao, Li-Xin;  Sheng, Li   |  收藏  |  浏览/下载：37/0  |  提交时间：2019/01/08 Benzo[c][1,2,5] thiadiazole derivatives  PTP1B  SHP2  Inhibitors  Structure-activity relationships (SAR)