中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [13]
昆明植物研究所 [2]
合肥物质科学研究院 [2]
长春应用化学研究所 [2]
化学研究所 [1]
近代物理研究所 [1]
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OAI收割 [21]
内容类型
期刊论文 [21]
发表日期
2024 [1]
2022 [1]
2021 [3]
2020 [1]
2019 [2]
2016 [1]
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学科主题
Pharmacolo... [3]
Chemistry [1]
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TRIP13-a potential drug target in cancer pharmacotherapy
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 151, 页码: 11
作者:
Bunu, Samuel Jacob
;
Cai, Haiyan
;
Wu, Leyun
;
Zhang, Hui
;
Zhou, Zhaoyin
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/09/26
AAA plus ATPase
TRIP13
Cancer
Drug target
Small-molecule inhibitors
Identification of PRMT5 inhibitors with novel scaffold structures through virtual screening and biological evaluations
期刊论文
OAI收割
JOURNAL OF MOLECULAR MODELING, 2022, 卷号: 28, 期号: 7, 页码: 184
作者:
Zhang, Qian
;
Zhang, Lun
;
Jin, Jia
;
Fan, Yaohua
;
Wang, Xiaoguang
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/03/21
PRMT5
Small-molecule inhibitors
Virtual screening
Molecular docking
Molecular dynamics simulations
If small molecules immunotherapy comes, can the prime be far behind?
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218
作者:
Zhang, Jingyu
;
Zhang, Yu
;
Qu, Bingxue
;
Yang, Haiyan
;
Hu, Shengquan
  |  
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2021/06/15
Cancer immunotherapy
Small molecule inhibitors
Combination therapy
Tumor microenvironment
Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
期刊论文
OAI收割
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15
作者:
Yu, Qing
;
Sun, Yi
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/03/15
anti-cancer drug
cullin-RING E3 ligases
natural product
high-throughput screen
neddylation
small-molecule inhibitors
Robustadial A and B from Eucalyptus globulus Labill. and their anticancer activity as selective tyrosyl-DNA phosphodiesterase 2 inhibitors
期刊论文
OAI收割
PHYTOTHERAPY RESEARCH, 2021, 卷号: 35, 期号: 9, 页码: 5282-5289
作者:
Zhang,Yu
;
He,Xiao-Zhi
;
Yang,Hao
;
Liu,Hai-Yang
;
An,Lin-Kun
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/04/02
anticancer
Eucalyptus globulus Labill
inhibitors
synergistic effect
tyrosyl-DNA phosphodiesterase
SMALL-MOLECULE INHIBITORS
1 TDP1
A patent review of BRD4 inhibitors (2013-2019)
期刊论文
OAI收割
EXPERT OPINION ON THERAPEUTIC PATENTS, 2020, 卷号: 30, 期号: 1, 页码: 57-81
作者:
Lu, Tian
;
Lu, Wenchao
;
Luo, Cheng
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
Bromodomain-containing protein 4 (BRD4)
bromodomain and extra-terminal (BET) family
small molecule inhibitors
cancer
patent
therapeutic potential
Computational Insight Into the Small Molecule Intervening PD-L1 Dimerization and the Potential Structure-Activity Relationship
期刊论文
OAI收割
FRONTIERS IN CHEMISTRY, 2019, 卷号: 7, 页码: 15
作者:
Shi, Danfeng
;
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Zhou, Shuangyan
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2022/01/19
PD-L1
small-molecule inhibitors
molecular dynamics simulation
metadynamics simulation
R-group QSAR
A patent review of arginine methyltransferase inhibitors (2010-2018)
期刊论文
OAI收割
EXPERT OPINION ON THERAPEUTIC PATENTS, 2019, 卷号: 29, 期号: 2, 页码: 97-114
作者:
Li, Xiao
;
Wang, Chen
;
Jiang, Hao
;
Luo, Cheng
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Arginine methylation
Protein arginine methyltransferases (PRMTs)
small molecule inhibitors
drug research and development
Histone lysine methyltransferases as anti-cancer targets for drug discovery
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 10, 页码: 1273-1280
作者:
Liu, Qing
;
Wang, Ming-wei
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
histone methyltransferases
adenosylmethionine
small molecule inhibitors
anti-cancer drugs
epigenetic modification
drug discovery
A cytotoxic amyloid oligomer self-triggered and NIR-enhanced amyloidosis therapeutic system
期刊论文
OAI收割
nano research, 2015, 卷号: 8, 期号: 7, 页码: 2431-2444
作者:
Xu,Can
;
Shi,Peng,Li,Meng
;
Ren,Jinsong
;
Qu,Xiaogang
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2016/05/03
SUPPORTED PHOSPHOLIPID-BILAYERS
RESPONSIVE CONTROLLED-RELEASE
ALZHEIMERS-DISEASE TREATMENT
SMALL-MOLECULE INHIBITORS
NEAR-INFRARED ABSORBENCY
ATOMIC-FORCE MICROSCOPY
MESOPOROUS SILICA
DRUG-DELIVERY
BETA-PROTEIN
IN-VIVO