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浏览/检索结果: 共404条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses 期刊论文  OAI收割 NATURE CHEMICAL BIOLOGY, 2024, 页码: 29 作者:  Zhou, Xiaoyu;  Zhao, Cheng;  Xu, Haiyan;  Xu, Yixiang;  Zhan, Li   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/25 Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 4, 页码: 2466-2486 作者:  Chang, Qi;  Li, Jiayi;  Deng, Yue;  Zhou, Ruilin;  Wang, Bingwei   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/25 Discovery of a potent and selective covalent threonine tyrosine kinase (TTK) inhibitor 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 16 作者:  Sun, Yaoliang;  Chen, Zhiwen;  Liu, Guobin;  Chen, Xiaoai;  Shi, Zihan   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/03/25 Inhibitor  Cancer  Threonine tyrosine kinase (TTK)  Covalent   Discovery and optimization of thieno[3,2-d]pyrimidine derivatives as highly selective inhibitors of cyclin-dependent kinase 7 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 263, 页码: 21 作者:  Zhang, Hongjin;  Lin, Guohao;  Jia, Suyun;  Zhang, Ying;  Wu, Jianbo   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/01/26 Thieno[3  d ]pyrimidine derivative  Cyclin-dependent kinase 7  Small molecule inhibitor  Kinome selectivity  Triple negative breast cancer   Structure-Guided Design, Synthesis, and Antivirulence Assessment of Covalent Staphylococcus aureus Sortase A Inhibitors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1127-1146 作者:  Yue, Chuan;  Yuan, Ziqi;  Xu, Guobin;  Guan, Xiang-Na;  Wei, Bingyan   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/02/27 Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025 作者:  Cheng, Jing;  Yan, Ziqin;  Jiang, Kailong;  Liu, Chen;  Xu, Dehua   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/02/19 From bench to bedside: current development and emerging trend of KRAS-targeted therapy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18 作者:  Chen, Yi;  Liu, Qiu-pei;  Xie, Hua;  Ding, Jian   |  收藏  |  浏览/下载：28/0  |  提交时间：2024/01/16 KRAS mutation  KRAS(G12C) inhibitor  Pan-KRAS inhibitor  SHP2 allosteric inhibitor  SOS1 inhibitor  combination therapy   Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933 作者:  Fang, Feifei;  Dai, Yang;  Wang, Hao;  Ji, Yinchun;  Liang, Xuewu   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/01/26 derivatives  Antitumor drug development  Potential AXL inhibitor  Antitumor activity  Structure-based drug design  Fused-pyrazolone carboxamide   The new direction of drug development: Degradation of undruggable targets through targeting chimera technology 期刊论文  OAI收割 MEDICINAL RESEARCH REVIEWS, 2023, 页码: 54 作者:  Liang, Xuewu;  Ren, Hairu;  Han, Fengyang;  Liang, Renwen;  Zhao, Jiayan   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/01/16 chimeric design  degradation System  PROTAC  targeted degradation technology  undruggable targets   Development of a novel 18F-labeled small molecule probe for PET imaging of mesenchymal epithelial transition receptor expression 期刊论文  OAI收割 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2023, 页码: 13 作者:  Bu, Lihong;  Ma, Xiaowei;  Ji, Aiyan;  Geng, Kaijun;  Feng, Hongyan   |  收藏  |  浏览/下载：7/0  |  提交时间：2023/12/19 Mesenchymal epithelial transition receptor  Gliomas  [18F]-AZC  PET  Quinoline derivative compound