中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [13]
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期刊论文 [72]
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Discovery and optimization of 3-(indolin-5-yloxy)pyridin-2-amine derivatives as potent necroptosis inhibitors
期刊论文
OAI收割
ARCHIV DER PHARMAZIE, 2024, 页码: 21
作者:
Lan, Yaohan
;
Ji, Yinchun
;
Peng, Xia
;
Duan, Wenhu
;
Geng, Meiyu
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/08/22
autoimmune disease
necroptosis inhibitor
pharmacokinetic profile
receptor interacting protein kinase 1 (RIPK1)
structural optimization
O型口蹄疫病毒衣壳蛋白VP1的可溶表达及抗原活性鉴定
期刊论文
OAI收割
过程工程学报, 2023, 卷号: 23, 期号: 3, 页码: 472
作者:
王闰年
;
张纯
;
吴佳奇
;
张耀
;
张宇翔
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2023/06/21
foot-and-mouth disease virus of serotype O
structural protein VP1
small ubiquitin-related modifier(SUMO)
RNA-interacting domain (RID)
soluble expression
immune response
O型口蹄疫病毒
结构蛋白VP1
小分子泛素相关修饰物(SUMO)
RNA作用结构域(RID)
可溶表达
免疫反应
Molecular dynamics simulations of ovalbumin adsorption at squalene/ water interface
期刊论文
OAI收割
CHINESE JOURNAL OF CHEMICAL ENGINEERING, 2022, 卷号: 50, 页码: 369-378
作者:
Xiong, Qingxia
;
Ren, Ying
;
Xia, Yufei
;
Ma, Guanghui
;
Noda, Reiji
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/02/24
Molecular dynamics simulation
Metadynamics
Protein adsorption
Structural stability
Ovalbumin
The allosteric gating mechanism of the MthK channel
期刊论文
OAI收割
NATIONAL SCIENCE REVIEW, 2022, 卷号: 9, 期号: 8, 页码: 12
作者:
Guan, Fenghui
;
Li, Tianyu
;
Dong, Wei
;
Guo, Rui
;
Chai, Hao
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2022/09/30
ion channel
allosteric gating mechanism
protein structural data analysis
The allosteric gating mechanism of the MthK channel
期刊论文
OAI收割
NATIONAL SCIENCE REVIEW, 2022, 卷号: 9
作者:
Guan, Fenghui
;
Li, Tianyu
;
Dong, Wei
;
Guo, Rui
;
Chai, Hao
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/12/23
ion channel
allosteric gating mechanism
protein structural data analysis
AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 7
作者:
He, Xin-heng
;
You, Chong-zhao
;
Jiang, Hua-liang
;
Jiang, Yi
;
Xu, H. Eric
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/08/16
G protein-coupled receptors
AlphaFold2
protein structure prediction
drug design
structural biology
The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 页码: 874474
作者:
Arunachalam, Karuppusamy
;
Sreeja, Puthanpura Sasidharan
;
Yang, Xuefei
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/08/21
reactive oxygen species
oxidative stress
antioxidant
diabetes mellitus
mushroom polysaccharides
AGARICUS-BLAZEI MURILL
GANODERMA-LUCIDUM POLYSACCHARIDES
ACTIVATED SIGNALING PATHWAYS
TYPE-2 DIABETES-MELLITUS
PROTEIN-KINASE-C
MT-ALPHA-GLUCAN
MEDICINAL MUSHROOM
SUBMERGED-CULTURE
PHELLINUS-LINTEUS
STRUCTURAL-CHARACTERIZATION
Picture-word order compound protein interaction: Predicting compound-protein interaction using structural images of compounds
期刊论文
OAI收割
JOURNAL OF COMPUTATIONAL CHEMISTRY, 2021, 页码: 10
作者:
Qian, Ying
;
Li, Xuelian
;
Wu, Jian
;
Zhou, Aimin
;
Xu, Zhijian
  |  
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2022/01/04
compound-protein interaction
convolutional neural network (CNN)
drug-drug interaction
image processing
structural images
Molecular structural heterogeneity of bisphenols governs their serum albumin binding
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 卷号: 781, 页码: -
作者:
Zhao, Xingchen
;
Li, Penghui
;
Song, Shanjun
;
Wang, Huiyu
;
Zhao, Lining
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/12/22
Bisphenots
Blood
Structural heterogeneity
Protein conformation
Molecular docking
CSConv2d: A 2-D Structural Convolution Neural Network with a Channel and Spatial Attention Mechanism for Protein-Ligand Binding Affinity Prediction
期刊论文
OAI收割
BIOMOLECULES, 2021, 卷号: 11, 期号: 5, 页码: 9
作者:
Wang, Xun
;
Liu, Dayan
;
Zhu, Jinfu
;
Rodriguez-Paton, Alfonso
;
Song, Tao
  |  
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2021/12/01
protein-ligand binding affinity
2-D structural CNN
spatial attention mechanism