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浏览/检索结果: 共286条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择发表日期升序发表日期降序题名升序题名降序提交时间升序提交时间降序作者升序作者降序 Dynamic-GLEP: a dynamics-informed deep learning framework for ligand efficacy prediction in representative Class A GPCRs 期刊论文  OAI收割 BRIEFINGS IN BIOINFORMATICS, 2026, 卷号: 27, 期号: 1, 页码: 15 作者:  Chen, Zhiyi;  Hao, Yongxin;  Su, Yuhong;  Agren, Hans;  Chen, Mingan   |  收藏  |  浏览/下载：0/0  |  提交时间：2026/04/01 GPCR ligand efficacy  molecular dynamics  conformational ensembles  deep learning  structure-based drug design  transfer learning   Structure-Based Development of Ultra-Broad-Spectrum 3C-Like Protease Inhibitors 期刊论文  OAI收割 ADVANCED SCIENCE, 2025, 页码: 17 作者:  Su, Haixia;  Nie, Tianqing;  Chen, Guofeng;  Xiong, Muya;  Zhang, Yumin   |  收藏  |  浏览/下载：0/0  |  提交时间：2026/01/29 3C-like protease  conservation analysis of the binding pocket  co-crystal structure  structure-based drug design  ultra-broad-spectrum inhibitors   Experimental Investigation of Shock-Wave-Streamwise-Vortex Interaction 期刊论文  OAI收割 AIAA JOURNAL, 2025, 卷号: 63, 期号: 8, 页码: 3079-3106 作者:  Wang, Ziao;  Yao, Kai;  Chang, Juntao;  Yue LJ(岳连捷);  Chen, Hao   |  收藏  |  浏览/下载：21/0  |  提交时间：2025/09/15 Shock Wave Interaction  Vortex Structure  Strong Oblique Shock Waves  Aerodynamics  Fluid Mechanics  Aircraft Wing Design  Supersonic Wind Tunnels  Aircraft Engines  Aircraft Components and Structure  Flow Conditions   An update for AlphaFold3 versus experimental structures: assessing the precision of small molecule binding in GPCRs 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2025, 页码: 10 作者:  Shen, Shi-yi;  Li, Jun-rui;  Wang, Yu-song;  Li, Shao-ning;  Xu, H. Eric   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/09/09 GPCR  AlphaFold3  experimental structures  global receptor architecture  orthosteric binding pockets  allosteric modulator  structure-based drug design   Design method for coral gravel limestone rock-like materials and its mechanical performance 期刊论文  OAI收割 CONSTRUCTION AND BUILDING MATERIALS, 2025, 卷号: 477, 页码: 15 作者:  Wang, Qilin;  Liu, Haifeng;  Zhang, Yongtao;  Chen, Peishuai;  Gong, Jianwu   |  收藏  |  浏览/下载：35/0  |  提交时间：2025/06/27 Coral reef limestone  Orthogonal design  CT scanning  Mix proportions  Pore structure characteristics  Stress-strain curve  Pore-throat network   AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2024, 页码: 12 作者:  He, Xin-heng;  Li, Jun-rui;  Shen, Shi-yi;  Xu, H. Eric   |  收藏  |  浏览/下载：52/0  |  提交时间：2025/01/14 AlphaFold  structure-based drug design  artificial intelligence  GPCR  structural biology   Experimental study on the effect of flexible joints of a deep-buried tunnel across an active fault under high in-situ stress conditions 期刊论文  OAI收割 UNDERGROUND SPACE, 2024, 卷号: 19, 页码: 189-207 作者:  Zhang, Jiawei;  Cui, Zhen;  Sheng, Qian;  Zhao, Wanhua;  Song, Liang   |  收藏  |  浏览/下载：27/0  |  提交时间：2025/06/27 Tunnel project  Crossing active fault  High in-situ stress  Segmental structure design  Flexible joint   HSIS-SIF a high-performance hyperspectral imaging spectrometer for Solar-Induced Chlorophyll Fluorescence of vegetation 期刊论文  OAI收割 OPTICS AND LASERS IN ENGINEERING, 2024, 卷号: 180 作者:  Wang, Tao;  Wu, Su;  Zheng, Shanshan;  Feng, Haisheng;  Wen, Jian   |  收藏  |  浏览/下载：65/0  |  提交时间：2024/11/20 SIF  Imaging spectrometer  Prism -grating structure  Optical design  Hyperspectral remote sensing   α" martensite engineering: A strategy to achieve high yield strength and low yield ratio synergy for dual-phase titanium alloy 期刊论文  OAI收割 MATERIALS & DESIGN, 2024, 卷号: 239, 页码: 15 作者:  Li, Diao-Feng;  Bai, Chun-Guang;  Zhang, Zhi-Qiang;  Wang, Ran;  Li, Nan   |  收藏  |  浏览/下载：2/0  |  提交时间：2025/04/27 Titanium alloy  alpha 'martensite  Yield ratio  Stress -induced martensite transformation  Heterogeneous structure design   Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17 作者:  Lan, Yaohan;  Peng, Xia;  Ji, Yinchun;  Su, Yi;  Duan, Wenhu   |  收藏  |  浏览/下载：79/0  |  提交时间：2024/02/27 AXL inhibitor  In vivo antitumor efficacy  6-Naphthyridin-4-one derivatives  Scaffold hopping  Structure-based drug design