中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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长春光学精密机械与... [65]
上海药物研究所 [43]
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AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 12
作者:
He, Xin-heng
;
Li, Jun-rui
;
Shen, Shi-yi
;
Xu, H. Eric
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/01/14
AlphaFold
structure-based drug design
artificial intelligence
GPCR
structural biology
HSIS-SIF a high-performance hyperspectral imaging spectrometer for Solar-Induced Chlorophyll Fluorescence of vegetation
期刊论文
OAI收割
OPTICS AND LASERS IN ENGINEERING, 2024, 卷号: 180
作者:
Wang, Tao
;
Wu, Su
;
Zheng, Shanshan
;
Feng, Haisheng
;
Wen, Jian
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/11/20
SIF
Imaging spectrometer
Prism -grating structure
Optical design
Hyperspectral remote sensing
Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17
作者:
Lan, Yaohan
;
Peng, Xia
;
Ji, Yinchun
;
Su, Yi
;
Duan, Wenhu
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2024/02/27
AXL inhibitor
In vivo antitumor efficacy
6-Naphthyridin-4-one derivatives
Scaffold hopping
Structure-based drug design
Structure-based development of potent and selective type-II kinase inhibitors of RIPK1
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334
作者:
Qin, Ying
;
Li, Dekang
;
Qi, Chunting
;
Xiang, Huaijiang
;
Meng, Huyan
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/03/06
RIPK1
Necroptosis
Type-II kinase inhibitors
Rational design
Lead optimization
Structure-activity relationship
Anti-inflammation
Preclinical drug discovery
Optimization design of optical windows for deep-sea pressure-resistant structures based on transition materials
期刊论文
OAI收割
FRONTIERS IN MARINE SCIENCE, 2023, 卷号: 10, 页码: 13
作者:
Wei, Yucong
;
Ma, Guoliang
;
Zhang, Hailong
;
Zhang, Xiaowei
;
Quan, Xiangqian
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2024/02/06
pressure-resistant structure
optical window design
finite element analysis
mechanical model analysis
optimized design scheme
Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933
作者:
Fang, Feifei
;
Dai, Yang
;
Wang, Hao
;
Ji, Yinchun
;
Liang, Xuewu
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/01/26
derivatives
Antitumor drug development
Potential AXL inhibitor
Antitumor activity
Structure-based drug design
Fused-pyrazolone carboxamide
Design and Analysis of High Temperature Superconducting Current Leads for CRAFT TF Magnet
期刊论文
OAI收割
IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY, 2023, 卷号: 33
作者:
Han, Quan
;
Lu, Kun
;
Song, Yuntao
;
Ding, Kaizhong
;
Liu, Chen
  |  
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2023/11/10
Analysis
Comprehensive Research Facility for Fusion Technology (CRAFT)
high-temperature superconducting current leads (HTSCL)
structure design
toroidal field (TF) magnet
Wavy interface enables extra strengthening in an additively manufactured high-entropy alloy with Mortise-Tenon architecture
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF PLASTICITY, 2023, 卷号: 170, 页码: 18
作者:
Bai, Yunjian
;
Li, Yadong
;
Wang, Yun-jiang
;
Zhang, Kun
;
Jiang, Quanyu
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2023/12/18
High entropy alloy
Laminated structure design
Additive manufacturing
Interface strengthening
Local chemical variation
Design and synthesis of 1H-pyrazolo[3,4-
d
]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 18
作者:
Zhang, Junjie
;
Li, Yan
;
Tang, Haotian
;
Zhou, Qianqian
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/12/08
Cancer immunotherapy
HPK1
Structure -based design
HPK1 inhibitor
Catalytic oxidation properties of 3D printed ceramics with Bouligand structures
期刊论文
OAI收割
Chemical Engineering Journal, 2023, 卷号: 474, 期号: 无, 页码: 145504
作者:
Xu X(徐昕)
;
He B(何波)
;
Wang YX(汪祎贤)
;
Xi YT(席云泰)
;
Liu DS(刘德胜)
  |  
收藏
  |  
浏览/下载:128/0
  |  
提交时间:2023/10/31
Bioinspired structural design
3D printing
Bouligand structure
Helicoidal catalytic ceramics
VOCs catalytic oxidation