机构

• 上海药物研究所 [8]
• 昆明植物研究所 [3]
• 新疆理化技术研究所 [1]
• 中国科学院大学 [1]

采集方式

• OAI收割 [12]
• iSwitch采集 [1]

内容类型

• 期刊论文 [13]

发表日期

• 2023 [1]
• 2022 [2]
• 2019 [2]
• 2018 [1]
• 2017 [1]
• 2016 [3]
• 更多

学科主题

• Chemistry,... [1]

筛选

浏览/检索结果: 共13条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Design, synthesis and biological evaluation of KRASG12C-PROTACs 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 78, 页码: 14 作者:  Zhang, Xiaoyi;  Zhao, Tong;  Sun, Minghao;  Li, Pei;  Lai, Mengzhen   |  收藏  |  浏览/下载：26/0  |  提交时间：2023/04/10 KRASG12C  PROTAC  Covalent inhibitors  Structure-activity relationships (SARs)  Anticancer   Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study 期刊论文  OAI收割 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 1411-1425 作者:  Sun, Yin;  Tang, Haotian;  Wang, Xiaoyan;  Feng, Fang;  Fan, Tiantian   |  收藏  |  浏览/下载：54/0  |  提交时间：2022/08/16 TBK1 inhibitors  1H-pyrazolo[3  4-b]pyridine  structure-activity relationships (SARs)  immune response  cancer therapy   Synthesis and Biological Activities of Dihydrooxazolo[5,4-d]- pyrrolo[1,2-a]pyrimidinones 期刊论文  OAI收割 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2022, 卷号: 42, 期号: 2, 页码: 543-556 作者:  Zeng, Y (Zeng Yan) [1] , [2];  Nie, LF (Nie Lifei) [1];  Niu, C (Niu Chao) [1];  Mamatjan, A (Mamatjan Aytilla) [1] , [2];  Bozorov, K (Bozorov Khurshed) [1]   |  收藏  |  浏览/下载：89/0  |  提交时间：2022/05/17 oxazopyrimidinone  synthesis  bioisosterism  anticancer activity  antimicrobial activity  structure-activity relationships (SARs)   Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/beta-catenin signalling pathway agonists 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2019, 卷号: 84, 页码: 285-294 作者:  Chen, Duo-zhi;  Yang, Bi-juan;  He, Xiao-li;  Fan, Shi-rui;  Cai, Jie-yun   |  收藏  |  浏览/下载：121/0  |  提交时间：2019/03/18 Wnt/beta-catenin signalling pathway agonist  Phenanthridine derivatives  Structural optimization  Structure-activity relationships (SARs)   Synthesis and antitumor activity of biotinylated camptothecin derivatives as potent cytotoxic agents 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 2, 页码: 234-237 作者:  Zi, Cheng-Ting;  Yang, Liu;  Xu, Feng-Qing;  Dong, Fa-Wu;  Ma, Rui-Jing   |  收藏  |  浏览/下载：114/0  |  提交时间：2019/03/18 Biodnylated Camptothecin Derivatives  Anticancer Activity  Synthesis  Click Chemistry  Structure-activity Relationships (Sars)   Discovery and structure-activity relationships study of thieno[2,3-b] pyridine analogues as hepatic gluconeogenesis inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 307-317 作者:  Ma, Fei;  Liu, Jian;  Zhou, Tingting;  Lei, Min;  Chen, Jing   |  收藏  |  浏览/下载：92/0  |  提交时间：2019/01/08 Thienol2,3-b]pyridine derivatives  Structure-activity relationships (SARs)  Hepatic gluconeogenesis  Type 2 diabetes mellitus (T2DM)   Synthesis and glucose-stimulate insulin secretion (GSIS) evaluation of vindoline derivatives 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 5, 页码: 1316-1318 作者:  Xiao, Chengqian;  Tian, Yunan;  Lei, Min;  Chen, Fanglei;  Gan, Xianwen   |  收藏  |  浏览/下载：25/0  |  提交时间：2019/01/08 Vindoline  Natural product  Glucose-stimulate insulin secretion (GSIS)  Structure-activity relationships (SARs)   Synthesis and cytotoxicity evaluation of 4 '-amino-4 '-dehydroxyloleandrin derivatives 期刊论文  iSwitch采集 Fitoterapia, 2016, 卷号: 113, 页码: 85-90 作者:  Chen, Hu;  Lei, Min;  Ma, Biao;  Liu, Miao;  Guo, Dean 收藏  |  浏览/下载：99/0  |  提交时间：2019/05/09 Oleandrin  Antitumor agent  Natural product  Cytotoxicity  Structure-activity relationships (sars)   Synthesis and cytotoxicity evaluation of 4 '-amino-4 '-dehydroxyloleandrin derivatives 期刊论文  OAI收割 FITOTERAPIA, 2016, 卷号: 113, 页码: 85-90 作者:  Chen, Hu;  Lei, Min;  Ma, Biao;  Liu, Miao;  Guo, Dean   |  收藏  |  浏览/下载：72/0  |  提交时间：2019/01/08 Oleandrin  Antitumor agent  Natural product  Cytotoxicity  Structure-activity relationships (SARs)   Synthesis and decreasing A beta content evaluation of arctigenin-4-yl carbamate derivatives 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 13, 页码: 2988-2991 作者:  Xu, Xingyu;  Li, Cong;  Lei, Min;  Zhu, Zhiyuan;  Yan, Jianming   |  收藏  |  浏览/下载：52/0  |  提交时间：2019/01/08 Arctigenin (ATG)  Natural product  Arctigenin-4-yl 3-carbamate  Structure-activity relationships (SARs)  Alzheimer's disease (AD)