中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [46]
武汉病毒研究所 [4]
生态环境研究中心 [3]
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期刊论文 [57]
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Twin drug design, synthesis and evaluation of diosgenin derivatives as multitargeted agents for the treatment of vascular dementia
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 37, 页码: 16
作者:
Yang, Gui-Xiang
;
Sun, Jia-Min
;
Zheng, Lu-Lu
;
Zhang, Li
;
Li, Jie
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/06/11
Vascular dementia
Diosgenin
Antioxidant
Anti-cholinesterase
Multi-target-directed ligands
neo-Clerodanes from the aerial parts of Salvia leucantha
期刊论文
OAI收割
TETRAHEDRON, 2016, 卷号: 72, 期号: 35, 页码: 5507-5514
作者:
Jiang, Yong-Jun
;
Su, Jia
;
Shi, Xin
;
Wu, Xing-De
;
Chen, Xuan-Qin
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2016/11/04
neo-Clerodanes
Salvia leucantha
Cytotoxicity
Heat shock protein 90 inhibitor
Acetyl cholinesterase inhibitory activity
Targeting neurotrophic factors and their receptors, but not cholinesterase or neurotransmitter, in the neurotoxicity of TDCPP in Chinese rare minnow adults (Gobiocypris rarus)
期刊论文
OAI收割
ENVIRONMENTAL POLLUTION, 2016, 卷号: 208, 期号: 0, 页码: 670-677
作者:
Zha, Jinmiao
;
Wang, Zijian
;
Li, Jiasu
;
Yuan, Lilai
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2017/04/01
Organophosphate Flame Retardants
Neurological Effects
Cholinesterase And Neurotransmitter Systems
Neurotrophic Factors
Chinese Rare Minnow
Rapid eye movement sleep behavior disorder in patients with probable Alzheimer's disease
期刊论文
OAI收割
Aging Clin Exp Res, 2016, 卷号: 28, 期号: 5, 页码: 951-7
作者:
Wang, P, Wing, Y. K, Xing, J, Liu, Y, Zhou, B, Zhang, Z, Yao, H, Guo, Y, Shang, Y, Zhang, X
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/03/05
Aged,Aged, 80 and over,Alzheimer Disease/*complications,Animals,Cholinesterase Inhibitors/therapeutic use,Electromyography,Female,Humans,Male,Middle Aged,Polysomnography,Probability,REM Sleep BehaviorDisorder/*epidemiology,Sleep/physiology,Sleep, REM/*physiology,Alzheimer's disease,REM sleep behavior disorder,REM sleep without atonia,Video-polysomnography
Antioxidant, cholinesterase inhibition activities and essential oil analysis of Nelumbo nucifera seeds
期刊论文
OAI收割
NATURAL PRODUCT RESEARCH, 2016, 卷号: 30, 期号: 11, 页码: 1335-1338
作者:
Khan, Shahnaz
;
Khan, Hidayatullah
;
Ali, Farman
;
Ali, Nayab
;
Khan, Fahim Ullah
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2017/03/27
Nelumbo nucifera
antioxidant
cholinesterase inhibition
essential oil
GC-MS analysis
A beta regulation-based multitarget strategy for drug discovery against Alzheimer's disease
期刊论文
OAI收割
REVIEWS IN THE NEUROSCIENCES, 2015, 卷号: 26, 期号: 1, 页码: 13-30
作者:
Guo, Xiaodan
;
Jiang, Wei
;
Li, Chenjing
;
Zhu, Zhiyuan
;
Shen, Xu
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
acetyl cholinesterase
Alzheimer's disease
autophagy
beta-amyloid
ER stress
lifespan
multitarget
oxidative stress
secretase
tau protein
Gold nanoclusters-Cu2+ ensemble-based fluorescence turn-on and real-time assay for acetylcholinesterase activity and inhibitor screening
期刊论文
OAI收割
biosensors & bioelectronics, 2015, 卷号: 74, 页码: 177-182
作者:
Sun,Jian
;
Yang,Xiurong
收藏
  |  
浏览/下载:140/0
  |  
提交时间:2016/05/04
SELECTIVE DETECTION
CHOLINESTERASE ACTIVITY
ENHANCED FLUORESCENCE
METAL NANOCLUSTERS
RAPID SYNTHESIS
QUANTUM DOTS
PROTEIN
PROBE
NANOPARTICLES
ENZYME
phaseistudyonthepharmacokineticsandtoleranceofzt1aprodrugofhuperzineaforthetreatmentofalzheimersdisease
期刊论文
OAI收割
actapharmacologicasinica, 2013, 卷号: 34, 期号: 7, 页码: 976
作者:
Jia Jingying
;
Zhao Qianhua
;
Liu Yun
;
Gui Yuzhou
;
Liu Gangyi
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
CHOLINESTERASE INHIBITOR
CHOLINERGIC HYPOTHESIS
PROGRESS
RAT
MEDICINE
VITRO
DRUG
ZT-1
huperzine A
prodrug
AChE inhibitor
drug tolerance
pharmacokinetics
Alzheimer's disease
Ameliorative effects of huperzine A on Alzheimer'sdisease associated mitochondrial dysfunction and its potential molecular mechanisms
期刊论文
OAI收割
Chinese Journal of New Drugs and Clinical Remedies, 2012, 卷号: 31, 期号: 12, 页码: 701-706
作者:
Ye Chunyan
;
Zhang Haiyan
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2019/01/08
Alzheimer disease
mitochondria
huperzine A
cholinesterase inhibitors
石杉碱甲改善阿尔采末病相关线粒体功能损伤及潜在分子机制
期刊论文
OAI收割
中国新药与临床杂志, 2012, 卷号: 31, 期号: 12, 页码: 701
作者:
叶春艳
;
章海燕
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2023/06/08
Alzheimer disease
mitochondria
huperzine A
cholinesterase inhibitors
阿尔茨海默病
线粒体
石杉碱甲
胆碱酯酶抑制剂