机构

• 上海药物研究所 [11]
• 金属研究所 [1]

采集方式

• OAI收割 [12]

内容类型

• 期刊论文 [12]

发表日期

• 2021 [2]
• 2019 [1]
• 2012 [3]
• 2011 [1]
• 2009 [1]
• 2007 [2]
• 更多

学科主题

• Biochemist... [2]
• Chemistry [2]
• Pharmacolo... [2]

筛选

浏览/检索结果: 共12条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14 作者:  He, Yu-Long;  Chen, Meng-Ting;  Wang, Ting;  Zhang, Ming-Ming;  Li, Ying-Xia   |  收藏  |  浏览/下载：62/0  |  提交时间：2021/11/04 Type 2 diabetes mellitus  Dual FABP4/5 inhibitors  Anti-lipolytic and anti-inflammatory effects  Metabolic stability  Anti-diabetic activities   Discovery of selective HDAC/BRD4 dual inhibitors as epigenetic probes 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 20 作者:  Chen, Jingjing;  Li, Yalei;  Zhang, Jie;  Zhang, Minmin;  Wei, Aihuan   |  收藏  |  浏览/下载：81/0  |  提交时间：2021/05/24 HDAC  BRD4  Selective dual inhibitors  Anticancer   Novel-targeted therapy for hematological malignancies with JAK and HDAC dual inhibitors 期刊论文  OAI收割 FUTURE MEDICINAL CHEMISTRY, 2019, 卷号: 11, 期号: 15, 页码: 1849-1852 作者:  Liang, Xuewu;  Liu, Hong;  Zhang, Yingjie   |  收藏  |  浏览/下载：27/0  |  提交时间：2020/07/01 dual inhibitors  HDAC  hematological malignancies  JAK  multiple target drugs   Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 卷号: 58, 页码: 624-639 作者:  Zhang, Lei;  Chen, Xiaojie;  Liu, Jun;  Zhu, Qingzhang;  Leng, Ying   |  收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08 Glycogen phosphorylase inhibitors  Glucokinase activators  Type 2 diabetes  Dual-target-directed  Hybrid   Discovery of novel selective inhibitors for EGFR-T790M/L858R 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 卷号: 22, 期号: 3, 页码: 1365-1370 作者:     |  收藏  |  浏览/下载：49/0  |  提交时间：2019/01/08 EGFR  T790M/L858R  Virtual screening  Kinase inhibitors  Selective inhibitors  Dual-effective inhibitors   Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety 期刊论文  OAI收割 CHINESE CHEMICAL LETTERS, 2012, 卷号: 23, 期号: 8, 页码: 915-918 作者:  Zhang Bei;  Zhao Yan Fang;  Zhai Xin;  Fan Wei Jie;  Ren Jun Ling   |  收藏  |  浏览/下载：15/0  |  提交时间：2021/02/26 RAF/MEK/ERK PATHWAY  DUAL-ACTION  INHIBITORS  TARGETS  SORAFENIB  CANCER  Diaryl ureas  N-acylhydrazone  Antiproliferative activities   Classification of 5-HT_(1A) receptor agonists and antagonists using GA-SVM method 期刊论文  OAI收割 Acta Pharmacologica Sinica, 2011, 卷号: 32, 期号: 11, 页码: 1424 作者:  Zhu Xuelian;  Cai Haiyan;  Xu Zhijian;  Wang Yong;  Wang Heyao   |  收藏  |  浏览/下载：27/0  |  提交时间：2020/07/01 VIVO PHARMACOLOGICAL EVALUATION  SEROTONIN TRANSPORTER AFFINITY  IN-VITRO  DUAL 5-HT1A  REUPTAKE INHIBITORS  LIGANDS  POTENT  DERIVATIVES  DISCOVERY  ANALOGS  5-HT1A receptor  support vector machine  genetic algorithm  agonist  antagonists   Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 卷号: 17, 期号: 20, 页码: 7301-7312 作者:  Zhang, Lei;  Li, Honglin;  Zhu, Qingzhang;  Liu, Jun;  Chen, Ling   |  收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08 Glucokinase (GK) activators  Glycogen phosphorylase (GP) inhibitors  Type 2 diabetes  Dual action   Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 卷号: 15, 期号: 3, 页码: 1394-1408 作者:  He, Xu-Chang;  Feng, Song;  Wang, Zhi-Fei;  Shi, Yufang;  Zheng, Suxin   |  收藏  |  浏览/下载：25/0  |  提交时间：2019/01/08 Huperzine B  acetylcholinesterase  Alzheimer's disease  dual-site binding inhibitors