机构

• 上海药物研究所 [6]
• 合肥物质科学研究院 [1]

采集方式

• OAI收割 [7]

内容类型

• 期刊论文 [7]

发表日期

• 2022 [1]
• 2020 [1]
• 2018 [1]
• 2016 [1]
• 2012 [3]

学科主题

筛选

浏览/检索结果: 共7条，第1-7条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists 期刊论文  OAI收割 PHARMACEUTICALS, 2022, 卷号: 15 作者:  Sun, Lei;  Zheng, Zhi-Ming;  Shao, Chang-Sheng;  Zhang, Zhi-Yong;  Li, Ming-Wei   |  收藏  |  浏览/下载：25/0  |  提交时间：2022/12/22 glucagon-like peptide-1  GLP-1 receptor agonist  functional protein design  molecular dynamics simulation  long-acting antihyperglycemic   Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide 期刊论文  OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 28, 页码: 9313-9325 作者:  Chang, Rulue;  Zhang, Xin;  Qiao, Anna;  Dai, Antao;  Belousoff, Matthew J.   |  收藏  |  浏览/下载：54/0  |  提交时间：2020/12/24 glucagon receptor  glucagon-like peptide-1 receptor  dual agonist  cryo-electron microscopy  single particle analysis  structure-function  structural biology  peptide 15 (P15)  metabolic disorder  G protein?coupled receptor (GPCR)  glucagon  GLP-1 receptor   Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism 期刊论文  OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 24, 页码: 9370-9387 作者:  Lei, Saifei;  Clydesdale, Lachlan;  Dai, Antao;  Cai, Xiaoqing;  Feng, Yang   |  收藏  |  浏览/下载：62/0  |  提交时间：2019/01/08 G protein-coupled receptor (GPCR)  glucagon  receptor structure-function  cell signaling  site-directed mutagenesis  biased agonism  GLP-1 receptor  glucagon-like peptide-1  class B peptide hormone  ERK kinase  arrestin  transmembrane domain   An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain 期刊论文  OAI收割 CELL DISCOVERY, 2016, 卷号: 2 作者:  Yin, Yanting;  Zhou, X. Edward;  Hou, Li;  Zhao, Li-Hua;  Liu, Bo   |  收藏  |  浏览/下载：34/0  |  提交时间：2019/01/08 GLP-1R  class B GPCR  intrinsic agonist  glucagon-like peptide-1  exendin-4  BETP   Acute and chronic administration of SHR117887, a novel and specific dipeptidyl peptidase-4 inhibitor, improves metabolic control in diabetic rodent models 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2012, 卷号: 33, 期号: 8, 页码: 1013-1022 作者:  Liu, Xiao;  Zhang, Li-na;  Feng, Ying;  Zhang, Lei;  Qu, Hui   |  收藏  |  浏览/下载：33/0  |  提交时间：2019/01/08 SHR117887  vildagliptin (LAF237)  dipeptidyl peptidase-4 (DPP-4)  type 2 diabetes mellitus  glucagon-like peptide-1 (GLP-1)  insulin  beta-cells   Substituted cyclobutane derivatives as non-peptidic GLP-1 receptor agonists 期刊论文  OAI收割 Chinese Bulletin of Life Sciences, 2012, 卷号: 24, 期号: 7, 页码: 626-633 作者:  Liu Qing;  He Min;  Zhou Caihong;  Wang Mingwei   |  收藏  |  浏览/下载：25/0  |  提交时间：2019/01/08 glucagon-like peptide-1(GLP-1)  cyclobutane derivatives  diabetes   acuteandchronicadministrationofshr117887anovelandspecificdipeptidylpeptidase4inhibitorimprovesmetaboliccontrolindiabeticrodentmodels 期刊论文  OAI收割 actapharmacologicasinica, 2012, 卷号: 33, 期号: 8, 页码: 1013 作者:  Liu Xiao;  Zhang Lina;  Ying Feng;  Zhang Lei;  Qu Hui   |  收藏  |  浏览/下载：18/0  |  提交时间：2020/07/01 GLUCAGON-LIKE PEPTIDE-1  IMPROVED GLUCOSE-TOLERANCE  DRUG-NAIVE PATIENTS  BETA-CELL FUNCTION  GLYCEMIC CONTROL  IV INHIBITOR  INSULIN-SECRETION  DOUBLE-BLIND  ZUCKER RATS  EFFICACY  SHR117887  vildagliptin (LAF237)  dipeptidyl peptidase-4 (DPP-4)  type 2 diabetes mellitus  glucagon-like peptide-1 (GLP-1)  insulin  beta-cells