机构

• 上海药物研究所 [14]

采集方式

• OAI收割 [14]

内容类型

• 期刊论文 [14]

发表日期

• 2025 [1]
• 2024 [1]
• 2023 [1]
• 2021 [4]
• 2020 [1]
• 2018 [1]
• 更多

学科主题

筛选

浏览/检索结果: 共14条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序作者升序作者降序题名升序题名降序发表日期升序发表日期降序 Discovery of pyrrolo[2,3-d]pyrimidine derivatives as novel FLT3/ IRAK4 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 23 作者:  Yuan, Haibin;  Gao, Yue;  Wang, Peipei;  Dong, Xiaowu;  Li, Jia   |  收藏  |  浏览/下载：6/0  |  提交时间：2025/08/20 AML  FLT3/IRAK4 inhibitor  Pyrrolo [2,3-d] pyrimidine  Acquired resistance  Adaptive resistance   Discovery of pyrrolo[2,3-d]pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 277, 页码: 17 作者:  Zhuang, Zhen;  Miao, Yu-Ling;  Song, Shan-Shan;  Leng, Guang-Tong;  Zhang, Xiao-Fei   |  收藏  |  浏览/下载：43/0  |  提交时间：2024/09/26 USP7 inhibitor  Structure-activity relationships  Anti-cancer  pyrrolo[2,3-d]pyrimidin-4-one   Application of deep generative model for design of Pyrrolo[2,3-d] pyrimidine derivatives as new selective TANK binding kinase 1 (TBK1) inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 247, 页码: 115034 作者:  Song, Shukai;  Tang, Haotian;  Ran, Ting;  Fang, Feng;  Tong, Linjiang   |  收藏  |  浏览/下载：39/0  |  提交时间：2024/03/27 SyntaLinker  Generative modelling  TBK1 inhibitor  pyrrolo[2  3-d]pyrimidine  Structure-activity relationship   Temperature-Controlled Divergent Synthesis of Tetrasubstituted Alkenes and Pyrrolo[1,2-a]indole Derivatives via Iridium Catalysis 期刊论文  OAI收割 ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2021, 页码: 14 作者:  Liu, Siyu;  Mao, Hui;  Qiao, Jin;  Zhang, Xiaoning;  Lu, Yangbin   |  收藏  |  浏览/下载：73/0  |  提交时间：2021/11/04 Iridium  C-H activation  [3+2] annulation  Tetrasubstituted alkene  pyrrolo[1,2-a]indole   Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18 作者:  Xu, Dandan;  Sun, Deqiao;  Wang, Wei;  Peng, Xia;  Zhan, Zhengsheng   |  收藏  |  浏览/下载：59/0  |  提交时间：2021/08/17 Axl  Cancer  Inhibitor  Pyrrolo[2,3-d]pyrimidine   Discovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 33, 页码: 127749 作者:  Yang, Bowen;  Wu, Qian;  Huan, Xiajuan;  Wang, Yingqing;  Sun, Yin   |  收藏  |  浏览/下载：40/0  |  提交时间：2024/03/21 TNIK inhibitor  1H-pyrrolo[2,3-b]pyridine  IL-2 secretion inhibitory   Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 10 作者:  Xiang, Hao-Yue;  Wang, Xiang;  Chen, Yan-Hong;  Zhang, Xi;  Tan, Cun   |  收藏  |  浏览/下载：41/0  |  提交时间：2021/05/24 PI3K  Pyrrolo[2,1-f][1,2,4]triazine  Anti-cancer  Target therapy   Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo [2,1-f] [1,2,4] triazine derivatives 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 12, 页码: 4 作者:  Xiang, Hao-Yue;  Chen, Yan-Hong;  Wang, Yi;  Zhang, Xi;  Ding, Jian   |  收藏  |  浏览/下载：45/0  |  提交时间：2020/07/01 Antiproliferative  Cancer  Therapy  PI3K inhibitors  Pyrrolo [2,1-f][1,2,4] triazine  Kinase   Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors 期刊论文  OAI收割 MOLECULES, 2018, 卷号: 23, 期号: 3 作者:  Jiang, Alan;  Liu, Qiufeng;  Wang, Ruifeng;  Wei, Peng;  Dai, Yang   |  收藏  |  浏览/下载：71/0  |  提交时间：2019/01/08 cancer  FGFR  kinase inhibitor  pyrrolo[2,3-b]pyrazine   Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 8, 期号: 8, 页码: 875-880 作者:  Yang, Chengbin;  Zhang, Xi;  Wang, Yi   |  收藏  |  浏览/下载：48/0  |  提交时间：2019/01/08 PI3K  PI3K/mTOR  oncology  1H-pyrrolo[2,3-b] pyridine  cancer therapy