机构

• 上海药物研究所 [17]

采集方式

• OAI收割 [17]

内容类型

• 期刊论文 [17]

发表日期

• 2020 [17]

学科主题

筛选

浏览/检索结果: 共17条，第1-10条 帮助 限定条件 发表日期：2020    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序题名升序题名降序作者升序作者降序发表日期升序发表日期降序 Substitution Effect of the Trifluoromethyl Group on the Bioactivity in Medicinal Chemistry: Statistical Analysis and Energy Calculations 期刊论文  OAI收割 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2020, 卷号: 60, 期号: 12, 页码: 6242-6250 作者:  Abula, Amina;  Xu, Zhijian;  Zhu, Zhengdan;  Peng, Cheng;  Chen, Zhaoqiang   |  收藏  |  浏览/下载：24/0  |  提交时间：2021/05/24 Computational Insights into the Conformational Accessibility and Binding Strength of SARS-CoV-2 Spike Protein to Human Angiotensin-Converting Enzyme 2 期刊论文  OAI收割 JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2020, 卷号: 11, 期号: 24, 页码: 10482-10488 作者:  Peng, Cheng;  Zhu, Zhengdan;  Shi, Yulong;  Wang, Xiaoyu;  Mu, Kaijie   |  收藏  |  浏览/下载：28/0  |  提交时间：2021/05/24 Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (ROR gamma t) modulators: insights into different protein behaviors with "short" and "long" inverse agonists 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11 作者:  Yu, Ming-cheng;  Yang, Feng;  Ding, Xiao-yu;  Sun, Nan-nan;  Jiang, Zheng-yuan   |  收藏  |  浏览/下载：95/0  |  提交时间：2020/12/24 RORγ  t  cocrystal structures  MD simulation  “  short”  inverse agonists  agonists  “  long”  inverse agonists   Identification of SARS-CoV-2 entry inhibitors among already approved drugs 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 7 作者:  Yang, Li;  Pei, Rong-juan;  Li, Heng;  Ma, Xin-na;  Zhou, Yu   |  收藏  |  浏览/下载：52/0  |  提交时间：2020/12/24 COVID-19  SARS-CoV-2  virus entry inhibitors  high throughput screening assay  approved drug library  histamine receptor antagonists  clemastine   MSpectraAI: a powerful platform for deciphering proteome profiling of multi-tumor mass spectrometry data by using deep neural networks 期刊论文  OAI收割 BMC BIOINFORMATICS, 2020, 卷号: 21, 期号: 1, 页码: 15 作者:  Wang, Shisheng;  Zhu, Hongwen;  Zhou, Hu;  Cheng, Jingqiu;  Yang, Hao   |  收藏  |  浏览/下载：20/0  |  提交时间：2020/12/24 Raw mass spectrometry data  Proteome profiling  Feature swath extraction  Deep neural networks  Multi-tumor types  Leave-one-out cross prediction strategy   Computational study of the substituent effect of halogenated fused-ring heteroaromatics on halogen bonding 期刊论文  OAI收割 JOURNAL OF MOLECULAR MODELING, 2020, 卷号: 26, 期号: 10, 页码: 12 作者:  Zhang, Qihua;  Smalley, Adam;  Zhu, Zhengdan;  Xu, Zhijian;  Peng, Cheng   |  收藏  |  浏览/下载：19/0  |  提交时间：2020/12/21 Halogen bonding  Fused-ring heteroaromatics  Quantum chemistry calculation  sigma-hole  Electrostatic potential  Binding energy   Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 13 作者:  Wang, Zheng;  Li, Zeng-xia;  Zhao, Wen-cao;  Huang, Hong-bo;  Wang, Jia-qi   |  收藏  |  浏览/下载：55/0  |  提交时间：2020/12/24 grincamycin B  marine natural product  isocitrate dehydrogenase 1  apoptosis  ER stress  intracellular ROS  Zebrafish embryos  hematological malignancies   Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 10 作者:  Yu, Yan-yan;  Cui, Shi-chao;  Zheng, Tian-nan;  Ma, Hai-jian;  Xie, Zhi-fu   |  收藏  |  浏览/下载：35/0  |  提交时间：2020/12/24 insulin resistance  sarsasapogenin  adipose tissue inflammation  macrophage-adipocyte crosstalk  IKK/NF-kappa B  JNK   D3Targets-2019-nCoV: a webserver for predicting drug targets and for multi-target and multi-site based virtual screening against COVID-19 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 7, 页码: 1239-1248 作者:  Shi, Yulong;  Zhang, Xinben;  Mu, Kaijie;  Peng, Cheng;  Zhu, Zhengdan   |  收藏  |  浏览/下载：31/0  |  提交时间：2020/12/24 COVID-19  SARS-CoV-2  Target prediction  Multi-conformation  Multi-site  Docking  D3Targets-2019-nCoV   A novel phosphoramide compound, DCZ0847, displays in vitro and in vivo anti-myeloma activity, alone or in combination with bortezomib 期刊论文  OAI收割 CANCER LETTERS, 2020, 卷号: 478, 页码: 45-55 作者:  Chen, Gege;  Hu, Ke;  Sun, Haiguo;  Zhou, Jinfeng;  Song, Dongliang   |  收藏  |  浏览/下载：33/0  |  提交时间：2020/07/01 Multiple myeloma  Bone marrow microenvironment  DNA damage  JAK2/STAT3 pathway