中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [30]
采集方式
OAI收割 [30]
内容类型
期刊论文 [30]
发表日期
2024 [1]
2023 [2]
2022 [4]
2021 [1]
2020 [3]
2018 [5]
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专题:上海药物研究所
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Proteasome activation: A novel strategy for targeting undruggable intrinsically disordered proteins
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 145, 页码: 17
作者:
Yu, Qian
;
Wang, Zheng
;
Tu, Yutong
;
Cao, Yu
;
Zhu, Huajian
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/05/07
20S proteasome
Proteasome activation
IDPs
Undruggable
Protein homeostasis
Natural product P57 induces hypothermia through targeting pyridoxal kinase
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 15
作者:
Wang, Ruina
;
Xiao, Lei
;
Pan, Jianbo
;
Bao, Guangsen
;
Zhu, Yunmei
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2024/02/19
Shape and Shear Stress Impact on the Toxicity of Mesoporous Silica Nanoparticles: In Vitro and In Vivo Evidence
期刊论文
OAI收割
MOLECULAR PHARMACEUTICS, 2023, 卷号: 20, 期号: 6, 页码: 3187-3201
作者:
Cheng, Yaxin
;
Tao, Jinsong
;
Zhang, Yaqi
;
Xi, Long
;
Han, Run
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2023/10/17
mesoporous silica nanoparticles (MSNs)
toxicity
shape
shear stress
in vitro blood flow model
Walking Dead Tumor Cells for Targeted Drug Delivery Against Lung Metastasis of Triple-Negative Breast Cancer
期刊论文
OAI收割
ADVANCED MATERIALS, 2022, 卷号: 34, 期号: 33, 页码: 2205462
作者:
Zhao, Zitong
;
Fang, Lei
;
Xiao, Ping
;
Sun, Xiangshi
;
Zhou, Lei
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/03/21
chemo-immunotherapy
drug delivery
metastasis
PD-1 blockade
triple-negative breast cancer
ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia
期刊论文
OAI收割
NUCLEIC ACIDS RESEARCH, 2022, 页码: 25
作者:
Lao, Linjiang
;
Bourdeau, Isabelle
;
Gagliardi, Lucia
;
He, Xiao
;
Shi, Wei
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/08/16
A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 10
作者:
Xu, Yingna
;
Feng, Wenbo
;
Zhou, Qingtong
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2022/06/15
Comprehensive Transcriptome Profiling of NAFLD- and NASH-Induced Skeletal Muscle Dysfunction
期刊论文
OAI收割
FRONTIERS IN ENDOCRINOLOGY, 2022, 卷号: 13, 页码: 14
作者:
Guo, Mingwei
;
Xiang, Liping
;
Yao, Jing
;
Zhang, Jun
;
Zhu, Shuangshuang
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2022/08/30
NAFLD
NASH
quadriceps muscle
lipid deposition
insulin resistance
myokines
Drug target inference by mining transcriptional data using a novel graph convolutional network framework
期刊论文
OAI收割
PROTEIN & CELL, 2021, 页码: 21
作者:
Zhong, Feisheng
;
Wu, Xiaolong
;
Yang, Ruirui
;
Li, Xutong
;
Wang, Dingyan
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/12/01
drug target inference
transcriptomics
deep learning
experimental verification
A novel bile acid analog, A17, ameliorated non-alcoholic steatohepatitis in high-fat diet-fed hamsters
期刊论文
OAI收割
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 卷号: 404, 页码: 14
作者:
Wang, Ying
;
Zhu, Yao
;
Niu, Junxing
;
Deng, Qiangqiang
;
Guo, Shimeng
  |  
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/12/21
Bile acid analog
NASH
TGR5
Cd36
AMPK alpha
Smart Tumor Microenvironment-Responsive Nanotheranostic Agent for Effective Cancer Therapy
期刊论文
OAI收割
ADVANCED FUNCTIONAL MATERIALS, 2020, 页码: 11
作者:
Guo, Shi-yan
;
Sun, Di
;
Ni, Da-long
;
Yu, Miao-rong
;
Qian, Kun
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
hypoxia relief
mesoporous calcium silicate
sequential functions
sustained drug release
synergetic effects