机构

• 上海药物研究所 [66]
• 上海生物化学与细胞生... [9]
• 大连化学物理研究所 [4]
• 力学研究所 [3]
• 合肥物质科学研究院 [3]
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• OAI收割 [101]
• iSwitch采集 [1]

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• 期刊论文 [101]
• 会议论文 [1]

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• 2024 [2]
• 2023 [9]
• 2022 [8]
• 2021 [15]
• 2020 [10]
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学科主题

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浏览/检索结果: 共102条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Real-time structural signatures of protein allostery by electrically- and mechanically-coupled sensing 期刊论文  OAI收割 NANO TODAY, 2024, 卷号: 55, 页码: 10 作者:  Zhang, Mingkun;  Zheng, Zhi;  Zhou, Jin;  Ding, Qihan;  Long, Mian   |  收藏  |  浏览/下载：18/0  |  提交时间：2024/03/25 Nanopore sensing  Atomic force microscopy (AFM)  Protein allostery  Steered molecular dynamics (SMD)  Spheroid approximation   JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文  OAI收割 CANCER LETTERS, 2024, 卷号: 582, 页码: 15 作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/04/07 Acquired resistance  Cancer  NSCLC  JC-010a  SHP2   From bench to bedside: current development and emerging trend of KRAS-targeted therapy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18 作者:  Chen, Yi;  Liu, Qiu-pei;  Xie, Hua;  Ding, Jian   |  收藏  |  浏览/下载：28/0  |  提交时间：2024/01/16 KRAS mutation  KRAS(G12C) inhibitor  Pan-KRAS inhibitor  SHP2 allosteric inhibitor  SOS1 inhibitor  combination therapy   Loops Mediate Agonist-Induced Activation of the Stimulator of Interferon Genes Protein 期刊论文  OAI收割 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2023, 页码: 9 作者:  Li, Rui;  Chen, Lin;  He, Xinheng;  Cao, Duanhua;  Zhang, Zehong   |  收藏  |  浏览/下载：7/0  |  提交时间：2023/12/11 Novel thieno[2,3-b]quinoline-procaine hybrid molecules: A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors 期刊论文  OAI收割 CHINESE CHEMICAL LETTERS, 2023, 卷号: 34, 期号: 8, 页码: 6 作者:  Xu, Lei;  Xuyan, Xuyang;  Minmi, Minmin;  Wang, Zhiji;  Shee, Chao   |  收藏  |  浏览/下载：27/0  |  提交时间：2023/10/17 Activator  PTPs  Inhibitor  Thieno[2  b ]quinoline derivatives  Diffuse large B-cell lymphoma   Elastic network models and molecular dynamic simulations reveal the molecular basis of allosteric regulation in ubiquitin-specific protease 7 (USP7) 期刊论文  OAI收割 COMPUTERS IN BIOLOGY AND MEDICINE, 2023, 卷号: 162, 页码: 10 作者:  Xu, Jing;  Wang, Yiran;  Zhang, Jiali;  Abdelmoneim, Amr Abbas;  Liang, Zhongjie   |  收藏  |  浏览/下载：16/0  |  提交时间：2023/10/17 USP7  Allosteric regulation  Elastic network models  Molecular dynamics simulations   Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers 期刊论文  OAI收割 CELL RESEARCH, 2023, 页码: 13 作者:  Wang, Xinwei;  Wang, Mu;  Xu, Tuo;  Feng, Ye;  Shao, Qiang   |  收藏  |  浏览/下载：12/0  |  提交时间：2023/10/17 A RhoA structure with switch II flipped outward revealed the conformational dynamics of switch II region 期刊论文  OAI收割 JOURNAL OF STRUCTURAL BIOLOGY, 2023, 卷号: 215, 期号: 2, 页码: 107942 作者:  Jiang, Hao;  Zu, Shijia;  Lu, Yu;  Sun, Zhongya;  Adeerjiang, Akejiang   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/03/27 Small GTPases  Crystal structures of RhoA  Dynamics of switch II  Molecular dynamics simulations  Allosteric pocket   Structural Mass Spectrometry Probes the Inhibitor-Induced Allosteric Activation of CDK12/CDK13-Cyclin K Dissociation 期刊论文  OAI收割 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 卷号: 145, 期号: 21, 页码: 11477-11481 作者:  Bai, Yu;  Liu, Zheyi;  Li, Yuanqing;  Zhao, Heng;  Lai, Can   |  收藏  |  浏览/下载：12/0  |  提交时间：2023/10/17 Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits 期刊论文  OAI收割 NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2023, 卷号: 30, 期号: 5, 页码: 629-+ 作者:  Zhang, Jilin;  Zhang, Ming;  Wang, Qinrui;  Wen, Han;  Liu, Zheyi   |  收藏  |  浏览/下载：2/0  |  提交时间：2024/03/27