机构

• 大连化学物理研究所 [38]
• 上海药物研究所 [11]
• 生态环境研究中心 [2]
• 化学研究所 [1]
• 武汉植物园 [1]

采集方式

• OAI收割 [52]
• iSwitch采集 [1]

内容类型

• 期刊论文 [33]
• 会议论文 [19]
• 学位论文 [1]

发表日期

• 2023 [1]
• 2020 [1]
• 2019 [3]
• 2018 [1]
• 2017 [3]
• 2016 [2]
• 更多

学科主题

• 物理化学 [21]

筛选

浏览/检索结果: 共53条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Design, synthesis and biological evaluation of chalcone derivatives as potent and orally active hCYP3A4 inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 95, 页码: 9 作者:  Lu, Shiwei;  Zhang, Feng;  Gong, Jiahao;  Huang, Jian;  Zhu, Guanghao   |  收藏  |  浏览/下载：10/0  |  提交时间：2023/12/08 Cytochrome P450 3A4 (CYP3A4)  Inhibitors  Isoquinoline chalcones  Orally active   Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11 作者:  Liu, Xiao-yun;  Guo, Zi-tao;  Chen, Zhen-dong;  Zhang, Yi-fan   |  收藏  |  浏览/下载：97/0  |  提交时间：2020/07/01 alflutinib  AST5902  metabolism  enzyme induction  drug-drug interaction   Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 423-439 作者:  Yu, Jianjun;  Liu, Jieyu;  Li, Daqiang;  Xu, Lei;  Hong, Duidui   |  收藏  |  浏览/下载：18/0  |  提交时间：2020/07/01 Proteasome inhibitors  Macrocyclic dipeptides  N-Benzyl amides  Metabolic stability   Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu 期刊论文  OAI收割 FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 10 作者:  Ma, Hong-Ping;  Dai, Zi-Ru;  Ning, Jing;  Sun, Gui-Bo;  Wang, Ping   |  收藏  |  浏览/下载：65/0  |  提交时间：2019/06/20 bufotalin  cytochrome P450 3A (CYP3A)  hydroxylation  human liver microsomes (HLMs)  docking simulations   Cytochrome p450 3a enzymes are key contributors for hepatic metabolism of bufotalin, a natural constitute in chinese medicine chansu 期刊论文  iSwitch采集 Frontiers in pharmacology, 2019, 卷号: 10, 页码: 10 作者:  Dai, Zi-Ru;  Ning, Jing;  Sun, Gui-Bo;  Wang, Ping;  Zhang, Feng 收藏  |  浏览/下载：87/0  |  提交时间：2019/05/08 Bufotalin  Cytochrome p450 3a (cyp3a)  Hydroxylation  Human liver microsomes (hlms)  Docking simulations   Differences in the In Vivo and In Vitro Metabolism of Imrecoxib in Humans: Formation of the Rate-Limiting Aldehyde Intermediate 期刊论文  OAI收割 DRUG METABOLISM AND DISPOSITION, 2018, 卷号: 46, 期号: 9, 页码: 1320-1328 作者:  Hou, Xiangyu;  Zhou, Jialan;  Yu, Songda;  Zhou, Lei;  Zhang, Yifan   |  收藏  |  浏览/下载：70/0  |  提交时间：2019/01/08 Strategy for Hepatotoxicity Prediction Induced by Drug Reactive Metabolites Using Human Liver Microsome and Online 2D-Nano-LC-MS Analysis 期刊论文  OAI收割 ANALYTICAL CHEMISTRY, 2017, 卷号: 89, 期号: 24, 页码: 13167-13175 作者:  Zhuo, Yue;  Wu, Jian-Lin;  Yan, Xiaojing;  Guo, Ming-Quan;  Liu, Ning   |  收藏  |  浏览/下载：85/0  |  提交时间：2017/12/31 Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2017, 卷号: 7, 期号: 6, 页码: 657-664 作者:  Cheng, Xuewei;  Lv, Xia;  Qu, Hengyan;  Li, Dandan;  Hu, Mengmeng   |  收藏  |  浏览/下载：26/0  |  提交时间：2019/06/20 Icotinib  Erlotinib  Ugt1a1  Inhibitory Effects  Drug-drug Interacts (Ddis)   Metabolic profiling of five flavonoids from Dragon's Blood in human liver microsomes using high-performance liquid chromatography coupled with high resolution mass spectrometry 期刊论文  OAI收割 JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2017, 卷号: 1052, 页码: 91-102 作者:  Li, Yujuan;  Zhang, Yushi;  Wang, Rui;  Wei, Lizhong;  Deng, Yulin   |  收藏  |  浏览/下载：21/0  |  提交时间：2018/04/10 Dragon's Blood  Human Liver Microsomes  Hplc-hr-ms  Metabolites   氟调醇的代谢转化机制研究 学位论文  OAI收割 硕士, 北京: 中国科学院研究生院, 2016 作者:  李忠民 收藏  |  浏览/下载：113/0  |  提交时间：2017/07/12 氟调醇  FTOHs  I相代谢  phase I metabolism  II相代谢  phase II metabolism  代谢动力学  metabolic kinetics  分子对接  molecular docking