中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [9]
上海生物化学与细胞生... [2]
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OAI收割 [11]
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期刊论文 [11]
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2022 [2]
2021 [1]
2020 [1]
2019 [2]
2018 [2]
2017 [1]
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Biochemist... [1]
Biophysics [1]
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Learning with uncertainty to accelerate the discovery of histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitors
期刊论文
OAI收割
BRIEFINGS IN BIOINFORMATICS, 2022, 页码: 14
作者:
Wang, Dong
;
Wu, Zhenxing
;
Shen, Chao
;
Bao, Lingjie
;
Luo, Hao
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/04/10
uncertainty estimation
graph neural network
KDM1A
LSD1 inhibitors
upper confidence bound method
virtual screening
Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 5, 页码: 4335-4349
作者:
Li, Chunpu
;
Su, Mingbo
;
Zhu, Wei
;
Kan, Weijuan
;
Ge, Tianpeng
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/06/15
Divalent tranylcypromine derivative as lysine-specific demethylase 1 inhibitor
期刊论文
OAI收割
MEDICINAL CHEMISTRY RESEARCH, 2021, 页码: 8
作者:
Sun, Yin
;
Li, Na
;
Su, Mingbo
;
Wang, Xiaowen
;
Zhao, Dongmei
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/05/24
Divalent tranylcypromine
LSD1 inhibitor
MV4-11 antiproliferative activity
CD86 mRNA expression
Linker
Selectivity
USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines
期刊论文
OAI收割
FEBS JOURNAL, 2020, 页码: 18
作者:
Wang, Hui
;
Meng, Qian
;
Ding, Yiluan
;
Xiong, Muya
;
Zhu, Mengying
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2020/12/24
colorectal cancer
HDX-MS
inhibitor
USP25
USP28
Vismodegib
Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 6, 页码: 844-847
作者:
Wang, Xiaowen
;
Su, Mingbo
;
Li, You
;
Liu, Tongchao
;
Wang, Yujie
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
LSD1 inhibitor
Tranylcypromine
Menin-MLL1 protei n-protein interaction inhibitor
MV4-11 antiproliferative activity
Structure activity relationship
Kdm1a promotes SCLC progression by transcriptionally silencing the tumor suppressor Rest
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 515, 期号: 1, 页码: 214-221
作者:
Jin, Yujuan
;
Ma, Dingailu
;
Gramyk, Tobin
;
Fang, Rui
;
Shi, Yujiang Geno
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/12/21
CELL LUNG-CANCER
REPRESSOR
DIFFERENTIATION
Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts
期刊论文
OAI收割
BONE RESEARCH, 2018, 卷号: 6, 期号: 14, 页码: -
作者:
Sun, Jun
;
Niu, Ningning
;
Yan, Guang
;
Yang, Yang
;
Zou, Weiguo
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/04/28
Mesenchymal Stem-cells
Brachydactyly Type A2
Gene-expression
Differentiation
Activation
Mouse
Methylation
Repression
Mutations
Leukemia
Novel spirocyclic tranylcypromine derivatives as lysine-specific demethylase 1 (LSD1) inhibitors
期刊论文
OAI收割
RSC ADVANCES, 2018, 卷号: 8, 期号: 3, 页码: 1666-1676
作者:
Shi, Ying
;
Wu, Yan-Ran
;
Su, Ming-Bo
;
Shen, Dong-Hao
;
Gunosewoyo, Hendra
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Tying up tranylcypromine: Novel selective histone lysine specific demethylase 1 (LSD1) inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 141, 页码: 101-112
作者:
Ji, Yue-Yang
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Tranylcypromine
LSD1
Stereoselective cyclopropanation
Chiral synthesis
MAO-A
MAO-B
Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells
期刊论文
OAI收割
CELL RESEARCH, 2011, 卷号: 21, 期号: 10, 页码: 1424-1435
作者:
Wang, Quan
;
Xu, Xinxiu
;
Li, Jun
;
Liu, Jing
;
Gu, Haifeng
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
lithium
induced pluripotent stem cells
iPS
GSK3 beta
Nanog
LSD1
histone demethylase