中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [21]
西北高原生物研究所 [10]
植物研究所 [10]
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期刊论文 [113]
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Novel imidazo[1,2,4] triazole derivatives: Synthesis, fluorescence, bioactivity for SHP1
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 15
作者:
Yan, Xue
;
Zhang, Chun
;
Gao, Li-Xin
;
Liu, Min -Min
;
Yang, Yu-Ting
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/02/27
Imidazo[124] triazole derivatives
Fluorescence property
SHP1
Bioactivity
Cellular imaging
Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways
期刊论文
OAI收割
BIOMOLECULES, 2023, 卷号: 13, 期号: 10, 页码: 14
作者:
Yuan, Xiaoyan
;
Yang, Junting
;
Huang, Yuling
;
Li, Jia
;
Li, Yuanyuan
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/12/08
gut-liver axis
3-Indolepropionic acid
HSCs
liver fibrosis
碘酸钠诱导大鼠视网膜退行性改变的作用机制
期刊论文
OAI收割
眼科新进展, 2023, 卷号: 43, 期号: 11, 页码: 853-857
作者:
邢岩
;
张丽梅
;
赵圆圆
;
侯思远
;
金锋
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2023/11/14
视网膜退行性改变
腆酸钠
蛋白质组学
年龄相关性黄斑变性
X-box Binding Protein 1: An Adaptor in the Pathogenesis of Atherosclerosis
期刊论文
OAI收割
AGING AND DISEASE, 2022, 页码: 20
作者:
Wang, Tao
;
Zhou, Jia
;
Zhang, Xiao
;
Wu, Yujie
;
Jin, Kehan
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/11/14
Endoplasmic Reticulum Stress
Unfolded Protein Response
XBP1
IRE1?
Atherosclerosis
Full-length transcriptome-referenced analysis reveals crucial roles of hormone and wounding during induction of aerial bulbils in lily
期刊论文
OAI收割
BMC PLANT BIOLOGY, 2022, 卷号: 22, 期号: 1
作者:
Li, Jingrui
;
Sun, Meiyu
;
Li, Hui
;
Ling, Zhengyi
;
Wang, Di
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/03/07
Bulbil induction
Full-length transcriptome
Oriental hybrid lily cultivar 'Sorbonne'
Hormone- and wounding-regulated network
Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1
期刊论文
OAI收割
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14
作者:
Zhang, Chun
;
Sun, Yi-Tao
;
Gao, Li-Xin
;
Feng, Bo
;
Yan, Xue
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2022/01/18
Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:
Meng, Xiang-Dong
;
Gao, Li-Xin
;
Wang, Zhi-Jia
;
Feng, Bo
;
Zhang, Chun
  |  
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2021/12/01
2,5-diphenyl-1,3,4-oxadiazole derivatives
SHP2
Inhibitors
Structure-activity relationships (SAR)
Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1)
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105
作者:
Yu Lijie
;
Feng Bo
;
Wang Zhijia
;
Gao Lixin
;
Zhang Chun
  |  
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2021/11/04
5-phenyl-1,3,4-thiadiazole derivatives
Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)
inhibitors
structure-activity relationships
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14
作者:
Yang, Xiangbo
;
Wang, Zhijia
;
Pei, Yuan
;
Song, Ning
;
Xu, Lei
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/08/17
SHP2 degradation
Proteolysis targeting chimera (PROTAC)
Thalidomide-based heterobifunctional molecules
E3 ubiquitin ligase
CRBN
Properties and gene expression profiling of acquired radioresistance in mouse breast cancer cells
期刊论文
OAI收割
ANNALS OF TRANSLATIONAL MEDICINE, 2021, 卷号: 9
作者:
Qin, Feng
;
Fan, Qiang
;
Yu, Peter K. N.
;
Almahi, Waleed Abdelbagi
;
Kong, Peizhong
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/06/15
Breast cancer
acquired radioresistance
gene expression profiling
energy metabolism