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浏览/检索结果: 共2300条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Zinc finger protein ZNF638 regulates triglyceride metabolism via ANGPTL8 in an estrogen dependent manner 期刊论文  OAI收割 METABOLISM-CLINICAL AND EXPERIMENTAL, 2024, 卷号: 152, 页码: 12 作者:  Meng, Meiyao;  Cao, Yuxiang;  Qiu, Jin;  Shan, Guangyu;  Wang, Yingwen   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/03/25 Triglyceride metabolism  ZNF638  Adipose tissue  Angptl8  Lipoprotein lipase   Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 4, 页码: 2466-2486 作者:  Chang, Qi;  Li, Jiayi;  Deng, Yue;  Zhou, Ruilin;  Wang, Bingwei   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/25 Novel imidazo[1,2,4] triazole derivatives: Synthesis, fluorescence, bioactivity for SHP1 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 15 作者:  Yan, Xue;  Zhang, Chun;  Gao, Li-Xin;  Liu, Min -Min;  Yang, Yu-Ting   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/02/27 Imidazo[124] triazole derivatives  Fluorescence property  SHP1  Bioactivity  Cellular imaging   JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文  OAI收割 CANCER LETTERS, 2024, 卷号: 582, 页码: 15 作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/04/07 Acquired resistance  Cancer  NSCLC  JC-010a  SHP2   Lindenane sesquiterpenoid dimers from Chloranthus japonicus improve LDL uptake by regulating PCSK9 and LDLR 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 142, 页码: 13 作者:  Guo, Pengju;  Chen, Tong;  Hu, Xianggang;  Duan, Yelin;  Zheng, Liu   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/01/16 Chloranthus japonicas  Lindenane sesquiterpenoid dimers  PCSK9  LDLR   The enzyme activity of sortase A is regulated by phosphorylation in Staphylococcus aureus 期刊论文  OAI收割 VIRULENCE, 2023, 卷号: 14, 期号: 1, 页码: 2171641 作者:  Chen, Feifei;  Di, Hongxia;  Wang, Yanhui;  Peng, Chao;  Chen, Rongrong   |  收藏  |  浏览/下载：2/0  |  提交时间：2024/03/27 Staphylococcus aureus  Sortase A  protein phosphorylation  virulence   FMRP phosphorylation modulates neuronal translation through YTHDF1 期刊论文  OAI收割 MOLECULAR CELL, 2023, 卷号: 83, 期号: 23 作者:  Zou, Zhongyu;  Wei, Jiangbo;  Chen, Yantao;  Kang, Yunhee;  Shi, Hailing   |  收藏  |  浏览/下载：4/0  |  提交时间：2024/03/27 Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025 作者:  Cheng, Jing;  Yan, Ziqin;  Jiang, Kailong;  Liu, Chen;  Xu, Dehua   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/02/19 Physiological and Pathological Functions of TRPM7 Channel and Its Small-molecule Modulators 期刊论文  OAI收割 PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2023, 卷号: 50, 期号: 12, 页码: 2856-2868 作者:  Wang, Yun-Qi;  Guan, Zi-Yue;  Gao, Zhao-Bing;  Zheng, Yue-Ming   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/04/09 TRPM7  ion channel  physiological function  disease  small molecule modulators   The new direction of drug development: Degradation of undruggable targets through targeting chimera technology 期刊论文  OAI收割 MEDICINAL RESEARCH REVIEWS, 2023, 页码: 54 作者:  Liang, Xuewu;  Ren, Hairu;  Han, Fengyang;  Liang, Renwen;  Zhao, Jiayan   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/01/16 chimeric design  degradation System  PROTAC  targeted degradation technology  undruggable targets