机构

• 上海药物研究所 [10]
• 高能物理研究所 [2]
• 上海生物化学与细胞生... [2]
• 深圳先进技术研究院 [1]
• 心理研究所 [1]
• 过程工程研究所 [1]
• 更多

采集方式

• OAI收割 [19]
• iSwitch采集 [2]

内容类型

• 期刊论文 [21]

发表日期

• 2023 [1]
• 2022 [2]
• 2021 [1]
• 2018 [3]
• 2017 [2]
• 2016 [3]
• 更多

学科主题

• Biochemist... [1]
• Gastroente... [1]
• Medical ps... [1]

筛选

浏览/检索结果: 共21条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 The new direction of drug development: Degradation of undruggable targets through targeting chimera technology 期刊论文  OAI收割 MEDICINAL RESEARCH REVIEWS, 2023, 页码: 54 作者:  Liang, Xuewu;  Ren, Hairu;  Han, Fengyang;  Liang, Renwen;  Zhao, Jiayan   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/01/16 chimeric design  degradation System  PROTAC  targeted degradation technology  undruggable targets   Natural Product-Inspired Targeted Protein Degraders: Advances and Perspectives 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 28 作者:  Li, Jiao;  Cai, Zhenyu;  Li, Xu-Wen;  Zhuang, Chunlin   |  收藏  |  浏览/下载：18/0  |  提交时间：2022/12/13 The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 229, 页码: 22 作者:  Li, Xiaokang;  Li, Jinwen;  Huang, Yunyuan;  Gong, Qi;  Fu, Yan   |  收藏  |  浏览/下载：31/0  |  提交时间：2022/06/15 Alzheimer's disease  Depression  Comorbidity  Multi-target-directed ligands   Protein degradation technology: a strategic paradigm shift in drug discovery 期刊论文  OAI收割 JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 卷号: 14 作者:  Li, Haobin;  Dong, Jinyun;  Cai, Maohua;  Xu, Zhiyuan;  Cheng, Xiang-Dong   |  收藏  |  浏览/下载：17/0  |  提交时间：2021/11/01 Protein degradation  Degradation pathway  Degradation technology  PROTAC  Monomeric degraders   Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 15, 页码: 6685-6704 作者:  Qin, Chong;  Hu, Yang;  Zhou, Bing;  Fernandez-Salas, Ester;  Yang, Chao-Yie   |  收藏  |  浏览/下载：45/0  |  提交时间：2019/01/08 Epitopes of MUC1 Tandem Repeats in Cancer as Revealed by Antibody Crystallography: Toward Glycopeptide Signature-Guided Therapy 期刊论文  OAI收割 MOLECULES, 2018, 卷号: 23, 期号: 6 作者:  Zhou, Dapeng;  Xu, Lan;  Huang, Wei;  Tonn, Torsten   |  收藏  |  浏览/下载：68/0  |  提交时间：2019/01/08 MUC1  tandem repeat  antibodies  glycopeptide  co-crystal   Whole genome engineering by synthesis 期刊论文  OAI收割 SCIENCE CHINA-LIFE SCIENCES, 2018 作者:  Dai, Junbiao;  Luo, Zhouqing;  Yang, Qing;  Geng, Binan;  Jiang, Shuangying   |  收藏  |  浏览/下载：28/0  |  提交时间：2019/01/31 Crystal structure determination of a chimeric FabF by XRD 期刊论文  OAI收割 NUCLEAR SCIENCE AND TECHNIQUES, 2017, 卷号: 28, 期号: 9 作者:  Li, Ke;  Li, Li;  Xu, Ye-Chun   |  收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08 FabF  Chimera  X-ray diffraction  Crystal structure determination   crystalstructuredeterminationofachimericfabfbyxrd 期刊论文  OAI收割 nuclearscienceandtechniques, 2017, 卷号: 028, 期号: 009, 页码: 123 作者:  Li Ke;  Li Li;  Xu Yechun   |  收藏  |  浏览/下载：2/0  |  提交时间：2020/07/01 晶体结构  嵌合体  XRD  广谱抗菌活性  测定  药物设计  生产菌株  PTM   Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes 期刊论文  OAI收割 PHARMACOLOGICAL REVIEWS, 2016, 卷号: 68, 期号: 4, 页码: 954-1013 作者:  de Graaf, Chris;  Donnelly, Dan;  Wootten, Denise;  Lau, Jesper;  Sexton, Patrick M.   |  收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08