中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17
作者:
Lan, Yaohan
;
Peng, Xia
;
Ji, Yinchun
;
Su, Yi
;
Duan, Wenhu
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/02/27
AXL inhibitor
In vivo antitumor efficacy
6-Naphthyridin-4-one derivatives
Scaffold hopping
Structure-based drug design
Integrated biomarker response to assess toxic impacts of iron and manganese on deep-sea mussel
Gigantidas platifrons
under a deep-sea mining activity scenario
期刊论文
OAI收割
JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2024, 页码: 11
作者:
Zhou, Li
;
Li, Mengna
;
Zhong, Zhaoshan
;
Wang, Minxiao
;
Chen, Hao
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/04/07
mussel
metal
deep-sea mining
biomarker
environmental monitoring
Low-Dose Chemotherapy Preferentially Shapes the Ileal Microbiome and Augments the Response to Immune Checkpoint Blockade by Activating AIM2 Inflammasome in Ileal Epithelial Cells
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 17
作者:
Pu, Congying
;
Li, Yize
;
Fu, Yixian
;
Yan, Yiyang
;
Tao, Siyao
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/02/27
AIM2 inflammasome
chemotherapy
gut microbiome
ileal epithelial cells
immune checkpoint blockade
lactobacillus
segmented filamentous bacterium
A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects
期刊论文
OAI收割
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 191, 页码: 9
作者:
Yang, Xin-Mei
;
Yang, Yang
;
Yao, Bu-Fan
;
Ye, Pan-Pan
;
Xu, Yan
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/12/11
COVID-19
Simnotrelvir
Safety
Pharmacokinetics
Healthy subjects
创伤后应激障碍与重性抑郁障碍症状的共生模式与机制:基于心理病理学网络视角
学位论文
OAI收割
中国科学院心理研究所: 中国科学院大学, 2023
作者:
陈琛
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/01/02
创伤后应激障碍
重性抑郁障碍
心理病理学
网络方法
共病
Monazite record of assimilation and differentiation processes in the petrogenesis of Himalayan leucogranites
期刊论文
OAI收割
CHEMICAL GEOLOGY, 2023, 卷号: 639, 页码: 17
作者:
Liu, Zhi-Chao
;
Wu, Fu-Yuan
;
Ji, Wei-Qiang
;
Liu, Xiao-Chi
;
Wang, Jian-Gang
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/27
Himalayan leucogranite
Monazite
In-situ analyses
Nd isotope
Assimilation
Fractional crystallization
Application of spectrochemical analysis with chemometrics to profile biochemical alterations in nanoplastic-exposed HepG2 cells
期刊论文
OAI收割
ENVIRONMENTAL POLLUTION, 2023, 卷号: 336, 页码: 12
作者:
Xing, Yu
;
Li, Jing
;
Yang, Jingjing
;
Li, Junyi
;
Pang, Weiyi
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/10/09
ATR-FTIR spectroscopy
Raman spectroscopy
Nanoplastics
Biochemical alterations
Repeated Low-Level Red Light Therapy for the Control of Myopia in Children: A Meta-Analysis of Randomized Controlled Trials
期刊论文
OAI收割
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE, 2023, 卷号: 49
作者:
Wang, Fei
;
Peng, Wei
;
Jiang, Zhengxuan
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/11/17
Repeated low-level red light
Myopia
Axial length
Cycloplegic
spherical equivalent refraction
Meta-analysis
Phenethylamine Is a Potential Density Stress Pheromone in Turbot (
Scophthalmus maximus
)
期刊论文
OAI收割
FISHES, 2023, 卷号: 8, 期号: 10, 页码: 17
作者:
Li, Jiyuan
;
Wang, Yanfeng
;
Guo, Teng
;
Xu, Shihong
;
Gao, Guang
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/11/30
pheromone
phenethylamine
metabolomics
Scophthalmus maximus
stocking density
Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CLpro inhibitors against SARS-CoV-2
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257, 页码: 13
作者:
Yang, Hanxi
;
You, Mengyuan
;
Shu, Xiaoyang
;
Zhen, Jingyao
;
Zhu, Mengwei
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/10/17
Peptidomimetics
Benzothiazolyl ketone
3CLpro inhibitor
Pharmacokinetic properties
SARS-CoV-2