中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [86]
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Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 258, 页码: 15
作者:
Kong, Linghui
;
Ning, Kuan
;
Liu, Xiao
;
Lu, Jiashuo
;
Chen, Baiyu
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
N-cyclopropylmethyl nornepenthone derivatives
derivatives
Structure-activity relationship
MOR antagonist
Functional reversal
Reversal of subtype-selectivity
Opioid use disorder
Molecular and Cellular Mechanisms of Neuropathic Pain in Aging
期刊论文
OAI收割
ACS CHEMICAL NEUROSCIENCE, 2023, 卷号: 14, 期号: 10, 页码: 1701-1716
作者:
Huang, Han
;
Wu, Jianwei
;
Chang, Yi
;
Wang, Hongwei
;
Tian, Ye
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
neuropathic pain
aging
intracellular calciumconcentration
oxidative stress
brain function
descending inhibition
innate immune cell population
central nervous system
comorbidity
Effect of early embryonic exposure to morphine on defects in the GABAergic system of day-old chicks
期刊论文
OAI收割
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2023, 卷号: 121, 页码: 9
作者:
Wang, Dongmei
;
Jiang, Juan
;
Shang, Wen
;
Zhang, Jianjun
;
Jiang, Xiao
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2022/12/16
Embryonic morphine exposure
gamma-Aminobutyric acid
Neuroelectrophysiology
Intermediate medial mesopallium (IMM)
Chicks
Addictive susceptibility
Molecular recognition of morphine and fentanyl by the human mu-opioid receptor
期刊论文
OAI收割
CELL, 2022, 卷号: 185, 期号: 23, 页码: 4361-+
作者:
Zhuang, Youwen
;
Wang, Yue
;
He, Bingqing
;
He, Xinheng
;
Zhou, X. Edward
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/04/10
Upregulation of dynorphin/kappa opioid receptor system in the dorsal hippocampus contributes to morphine withdrawal-induced place aversion
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 8
作者:
Chen, Yan
;
Wang, Chen-yao
;
Zan, Gui-ying
;
Yao, Song-yu
;
Deng, Ying-zhi
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2022/11/11
morphine withdrawal
conditioned place aversion
kappa opioid receptor
p38 MAPK
norBNI
dorsal hippocampus
Recent progress in assays for GPCR drug discovery
期刊论文
OAI收割
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022, 卷号: 323, 期号: 2, 页码: C583-C594
作者:
Guo, Shimeng
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收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/04/10
biased signaling
GPCR
high -throughput screening assays
humanized mouse model
protein
protein interaction
Antinociceptive activities and mechanism of action of Cepharanthine
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 卷号: 614, 页码: 219-224
作者:
Wei, Xiang-Yan
;
Long, Jian-Dong
;
Chai, Jing-Rui
;
Chen, Jing
;
Gao, Jian-Ping
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/08/16
Cepharanthine
Antinociception
mu opioid receptors
Constipation
Humans have used opioids to suppress moderate to severe pain for thousands of years. However, the long-term use of opioids has several adverse effects, such as opioid tolerance, opioid-induced hyperal
期刊论文
OAI收割
International Journal of Environmental Research and Public Health, 2022, 卷号: 19, 期号: 4, 页码: 11
作者:
Wang, Xiaqing
;
Bao, Chongyu
;
Li, Zhenjiang
;
Yue, Lupeng
;
Hu, Li
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/04/02
Side Effects of Opioids Are Ameliorated by Regulating TRPV1 Receptors
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2022, 卷号: 19, 期号: 4, 页码: 11
作者:
Xiaqing Wang
;
Chongyu Bao
;
Zhenjiang Li
;
Lupeng Yue
;
Li Hu
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/04/02
TRPV1
µ-opioid
opioid side effects
neuropathic pain
β-arrestin2
Dezocine as a potent analgesic: overview of its pharmacological characterization
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Ye, Rong-Rong
;
Jiang, Shuang
;
Xu, Xu
;
Lu, Yan
;
Wang, Yu-Jun
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/12/16
dezocine
opioid receptors
norepinephrine
serotonin transporter
postoperative pain
anesthesia