中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [103]
烟台海岸带研究所 [22]
生态环境研究中心 [14]
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OAI收割 [231]
内容类型
期刊论文 [230]
专利 [1]
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2022 [231]
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Biochemist... [1]
Chemistry [1]
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浏览/检索结果:
共231条,第1-10条
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发表日期:2022
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Design and synthesis of chromone-nitrogen mustard derivatives and evaluation of anti-breast cancer activity
期刊论文
OAI收割
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 431-444
作者:
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收藏
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浏览/下载:33/0
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提交时间:2022/06/15
Chromone
nitrogen mustard
breast cancer
apoptosis
Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties
期刊论文
OAI收割
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 1537-1555
作者:
Li, Ennian
;
Wang, Kai
;
Zhang, Bei
;
Guo, Siqi
;
Xiao, Senhao
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收藏
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浏览/下载:37/0
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提交时间:2022/08/16
DNMT1 inhibitor
A549 cell lines
HCT116 cell lines
antitumor activity
pharmacokinetic
Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study
期刊论文
OAI收割
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 1411-1425
作者:
Sun, Yin
;
Tang, Haotian
;
Wang, Xiaoyan
;
Feng, Fang
;
Fan, Tiantian
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收藏
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浏览/下载:36/0
  |  
提交时间:2022/08/16
TBK1 inhibitors
1H-pyrazolo[3
4-b]pyridine
structure-activity relationships (SARs)
immune response
cancer therapy
Surface Self-Assembly of Dipeptides on Porous CaCO3 Particles Promoting Cell Internalization
期刊论文
OAI收割
ACS APPLIED MATERIALS & INTERFACES, 2022, 页码: 12
作者:
Ma, Yuqi
;
Wang, Anhe
;
Li, Jieling
;
Li, Qi
;
Han, Qingquan
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收藏
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浏览/下载:24/0
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提交时间:2023/02/24
peptide self-assembly
CaCO3 particles
surface modification
cell internalization
cancer therapy
Study on structure-activity relationship (SAR) of simplified mirogabalin derivatives as voltage-gated calcium channel alpha 2 delta ligands for the treatment of chronic neuropathic pain
期刊论文
OAI收割
MEDICINAL CHEMISTRY RESEARCH, 2022, 页码: 26
作者:
Zhang, Yuanwen
;
Zheng, Yueming
;
Wu, Qingqing
;
Tian, Fuyun
;
Ma, Chuanjun
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收藏
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浏览/下载:24/0
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提交时间:2023/04/10
Voltage-gated calcium channel
alpha 2 delta subunit
gamma-aminobutyric acid
Mirogabalin
Neuropathic pain
Structure-activity relationship
Two Terpenoid Derivatives with Different 3/5/6/6/5-Fused Pentacyclic Skeletons from Hedyosmum orientale
期刊论文
OAI收割
CHINESE JOURNAL OF CHEMISTRY, 2022, 页码: 7
作者:
Fan, Yao-Yue
;
Zheng, Cheng-Yu
;
Zhou, Bin
;
Zimbres, Flavia M. M.
;
Cassera, Maria B. B.
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收藏
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浏览/下载:26/0
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提交时间:2023/04/10
Natural products
C-25 Terpenoids
Structure elucidation
Biosynthetic pathway hypothesis
Antimalarial activity
Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV-1 Activities and Improved Oral Bioavailability
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 24, 页码: 16526-16540
作者:
Xie, Xiong
;
Zheng, Yu-Gui
;
Chen, Huan
;
Li, Jian
;
Luo, Rong-Hua
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收藏
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浏览/下载:26/0
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提交时间:2023/04/10
Preparation of cationic chitooligosaccharide derivatives bearing N-halogenated benzyl pyridinium and assessment of their antimicrobial activities
期刊论文
OAI收割
POLYMER BULLETIN, 2022, 页码: 18
作者:
Lin, Conghao
;
Yuan, Yuting
;
Tan, Wenqiang
;
Guo, Zhanyong
;
Jiang, Aili
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收藏
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浏览/下载:9/0
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提交时间:2023/08/17
Cationic chitooligosaccharide derivatives
N-Halogenated benzyl pyridinium
Antimicrobial
A NOVEL AUGMENTED LAGRANGIAN METHOD OF MULTIPLIERS FOR OPTIMIZATION WITH GENERAL INEQUALITY CONSTRAINTS
期刊论文
OAI收割
MATHEMATICS OF COMPUTATION, 2022, 页码: 30
作者:
Liu, Xin-Wei
;
Dai, Yu-Hong
;
Huang, Ya-Kui
;
Sun, Jie
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收藏
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浏览/下载:19/0
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提交时间:2023/02/07
Nonlinear programming
inequality-constrained optimization
augmented Lagrangian method of multipliers
strong global convergence
local convergence
Copper-catalyzed multicomponent assembly of gamma-butenolides via the interception of carbonyl ylides with iminium ions
期刊论文
OAI收割
ORGANIC & BIOMOLECULAR CHEMISTRY, 2022, 页码: 6
作者:
Zhang, Mengchu
;
Yu, Sifan
;
Hua, Ruyu
;
Zhang, Dan
;
Qiu, Huang
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收藏
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浏览/下载:14/0
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提交时间:2023/04/10