中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [25]
生态环境研究中心 [4]
过程工程研究所 [3]
金属研究所 [2]
合肥物质科学研究院 [2]
烟台海岸带研究所 [2]
更多
采集方式
OAI收割 [40]
内容类型
期刊论文 [40]
发表日期
2022 [40]
学科主题
Metals [1]
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发表日期:2022
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Discovery of Highly Potent Nicotinamide Phosphoribosyltransferase Degraders for Efficient Treatment of Ovarian Cancer
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 15
作者:
Bi, Kaijian
;
Cheng, Junfei
;
He, Shipeng
;
Fang, Yuxin
;
Huang, Min
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2023/04/10
ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 页码: 9
作者:
Song, Peiran
;
Bai, Gang
;
Chan, Shingpan
;
Zhang, Tao
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2023/04/10
Bruton's tyrosine kinase
interleukin-2-inducible T cell kinase
ASK120067
B-cell lymphoma
T-cell leukemia
Identification of Novel Antifungal Skeleton of Hydroxyethyl Naphthalimides with Synergistic Potential for Chemical and Dynamic Treatments
期刊论文
OAI收割
MOLECULES, 2022, 卷号: 27, 期号: 23, 页码: 22
作者:
Zhang, Pengli
;
Tangadanchu, Vijai Kumar Reddy
;
Zhou, Chenghe
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2023/04/10
naphthalimide
antifungal
reactive oxygen species
membrane
Discovery of Novel N-(5-(Pyridin-3-yl)-1H-indazol-3-yl)benzamide Derivatives as Potent Cyclin-Dependent Kinase 7 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 19
作者:
Yang, Bowen
;
Zhang, Haoran
;
Li, Na
;
Gao, Lixin
;
Jiang, Hong
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2023/04/10
Design and exploration of gut-restricted bifunctional molecule with TGR5 agonistic and DPP4 inhibitory effects for treating ulcerative colitis
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 242, 页码: 114697
作者:
Han, Fanghui
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/21
Bifunctional molecule
Gut-restricted
Ulcerative colitis
TGR5
DPP4
Molecular Determinants for the High-Affinity Blockade of Human Ether-a-go-go-Related Gene K+ Channel by Tolterodine
期刊论文
OAI收割
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2022, 卷号: 80, 期号: 5, 页码: 679-689
作者:
Wang, Na
;
Yang, Yang
;
Wen, Jing
;
Fan, Xin-Rong
;
Li, Jian
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/12/13
tolterodine
hERG channel
molecular docking
muscarinic acetylcholine receptor
tachycardia
overactive bladder
Structure-based design of a novel inhibitor of the ZIKA virus NS2B/ NS3 protease
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2022, 卷号: 128, 页码: 7
作者:
Xiong, Yanchao
;
Cheng, Fei
;
Zhang, Junyi
;
Su, Haixia
;
Hu, Hangchen
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2022/11/11
Zika virus
Fragment -based hit screening
Protein -inhibitor interactions
NS2B
NS3 protease
Crystal structure
Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 10
作者:
Song, Jia
;
Yang, Rui-rui
;
Chang, Jie
;
Liu, Ya-dan
;
Lu, Cheng-hao
  |  
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2022/11/11
cyclic GMP-AMP synthase
covalent inhibitor
inflammatory bowel disease
high-throughput screening
Discovery of potent ebola entry inhibitors with (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 240, 页码: 12
作者:
Han, Sheng
;
Li, Heng
;
Chen, Weixiong
;
Yang, Li
;
Tong, Xiankun
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2022/11/11
Ebola virus
Entry inhibitor
Structural optimization
New Rufomycins from Streptomyces atratus MJM3502 Expand Anti- Mycobacterium tuberculosis Structure-Activity Relationships
期刊论文
OAI收割
ORGANIC LETTERS, 2022, 页码: 6
作者:
Zhou, Bin
;
Shetye, Gauri
;
Wolf, Nina M.
;
Chen, Shao-Nong
;
Qader, Mallique
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/12/13