机构

• 上海药物研究所 [30]
• 海洋研究所 [1]
• 自动化研究所 [1]

采集方式

• OAI收割 [32]

内容类型

• 期刊论文 [32]

发表日期

• 2023 [32]

学科主题

筛选

浏览/检索结果: 共32条，第1-10条 帮助 限定条件 发表日期：2023     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of a novel GPR35 agonist with high and equipotent species potency for oral treatment of IBD 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 96, 页码: 12 作者:  Song, Zhaoxiang;  Lu, Dan;  Sun, Jun;  Ye, Yangliang;  Fang, Jiahui   |  收藏  |  浏览/下载：26/0  |  提交时间：2024/01/16 GPR35  IBD  Lodoxamide   Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14 作者:  Liu, Jiayuan;  Zhang, Xianglei;  Chen, Guofeng;  Shao, Qiang;  Zou, Yi   |  收藏  |  浏览/下载：18/0  |  提交时间：2024/01/16 Phosphodiesterase-4 (PDE4)  PDE5  Inhibitor  Drug repurposing  Crystal structure  Structure -guided optimization   Discovery of 5-trifluoromethyl-2-aminopyrimidine derivatives as potent dual inhibitors of FLT3 and CHK1 期刊论文  OAI收割 RSC MEDICINAL CHEMISTRY, 2023, 页码: 14 作者:  Deng, Minjie;  Gao, Yue;  Wang, Peipei;  Du, Wenjing;  Xu, Gaoya   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/02/19 Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764 作者:  Liu, Yingqiang;  Zhan, Zhengsheng;  Kang, Zhuang;  Li, Mengyuan;  Lv, Yongcong   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/01/26 Small molecule inhibitor  Tumor microenvironment  Immune-checkpoint  immune-deficient mouse models  including temozolomide (TMZ) insensitive tumors. Notably   HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation 期刊论文  OAI收割 CELL CHEMICAL BIOLOGY, 2023, 卷号: 30, 期号: 11, 页码: 1421-+ 作者:  Xiao, Yufeng;  Hale, Seth;  Awasthee, Nikee;  Meng, Chengcheng;  Zhang, Xuan   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/01/16 The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 12 作者:  Cui, Shi-hao;  Suo, Na;  Yang, Ying;  Wu, Xuan;  Guo, Shi-meng   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/12/11 oligodendrocyte  oligodendrocyte progenitor cell  differentiation  remyelination  U73122   Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy 期刊论文  OAI收割 EMBO MOLECULAR MEDICINE, 2023, 页码: 20 作者:  So, Wing Yan;  Liao, Yilie;  Liu, Wai Nam;  Rutter, Guy A.;  Han, Weiping   |  收藏  |  浏览/下载：6/0  |  提交时间：2023/12/11 AAV  beta cells  diabetes  islet transplant  PAX6   Enhancing Dimensional Emotion Recognition from Speech through Modulation-Filtered Cochleagram and Parallel Attention Recurrent Network 期刊论文  OAI收割 ELECTRONICS, 2023, 卷号: 12, 期号: 22, 页码: 15 作者:  Peng, Zhichao;  Zeng, Hua;  Li, Yongwei;  Du, Yegang;  Dang, Jianwu   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/02/22 modulation-filtered cochleagram  parallel attention recurrent neural network  dimensional emotion recognition  auditory signal processing  noise-robust   A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir 期刊论文  OAI收割 SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 卷号: 8, 期号: 1, 页码: 10 作者:  Zhang, Yumin;  Sun, Yuan;  Xie, Yuanchao;  Shang, Weijuan;  Wang, Zhen   |  收藏  |  浏览/下载：5/0  |  提交时间：2023/12/08 Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CLpro inhibitors against SARS-CoV-2 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257, 页码: 13 作者:  Yang, Hanxi;  You, Mengyuan;  Shu, Xiaoyang;  Zhen, Jingyao;  Zhu, Mengwei   |  收藏  |  浏览/下载：13/0  |  提交时间：2023/10/17 Peptidomimetics  Benzothiazolyl ketone  3CLpro inhibitor  Pharmacokinetic properties  SARS-CoV-2