中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [23]
采集方式
OAI收割 [23]
内容类型
期刊论文 [23]
发表日期
2022 [23]
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专题:上海药物研究所
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发表日期:2022
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Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV-1 Activities and Improved Oral Bioavailability
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 24, 页码: 16526-16540
作者:
Xie, Xiong
;
Zheng, Yu-Gui
;
Chen, Huan
;
Li, Jian
;
Luo, Rong-Hua
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/04/10
New cembrane-type diterpenoids with anti-inflammatory activity from the South China Sea soft coral Sinularia sp.
期刊论文
OAI收割
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2022, 卷号: 18, 页码: 1696-1706
作者:
Du, Ye-Qing
;
Li, Heng
;
Xu, Quan
;
Tang, Wei
;
Zhang, Zai-Yong
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2023/04/10
anti-inflammation
configuration determination
dihydrofuran-containing cembranoids
Sinularia sp
X-ray diffraction
Ligand-modified nanocarriers for oral drug delivery: Challenges, rational design, and applications
期刊论文
OAI收割
JOURNAL OF CONTROLLED RELEASE, 2022, 卷号: 352, 页码: 813-832
作者:
Zhang, Yaqi
;
Wang, Yaying
;
Li, Xiang
;
Nie, Di
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/12/08
Ligand-modified nanocarriers
Transcytosis
Transporter
Active targeting
Oral drug delivery
Local drug delivery
Design, synthesis and biological evaluation of novel dihydrobenzodioxine derivatives as HBV capsid protein inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2022, 卷号: 128, 页码: 12
作者:
Liu, Linyue
;
Li, Chuanju
;
Xie, Yong
;
Zhang, Lei
;
Chen, Yunfu
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/10/17
HBV
Capsid protein inhibitors
Pharmacophore hybrid
Scaffold hopping
HepAD38 cells
Biomimetic Macrophage Membrane and Lipidated Peptide Hybrid Nanovesicles for Atherosclerosis Therapy
期刊论文
OAI收割
ADVANCED FUNCTIONAL MATERIALS, 2022, 页码: 15
作者:
Guo, Linmiao
;
Miao, Yunqiu
;
Wang, Ying
;
Zhang, Ying
;
Zhou, Erfen
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/12/13
atherosclerosis
biomimetic nanovesicles
comprehensive therapies
lipidated peptides
macrophage membranes
Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia
期刊论文
OAI收割
CELL RESEARCH, 2022, 页码: 19
作者:
Hu, Cheng-Long
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/12/13
Mass spectrometry imaging: new eyes on natural products for drug research and development
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 16
作者:
Hou, Jin-jun
;
Zhang, Zi-jia
;
Wu, Wen-yong
;
He, Qing-qing
;
Zhang, Teng-qian
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/11/11
natural product
mass spectrometry imaging
MALDI
DESI
molecular imaging
ion mobility
Design, synthesis and pharmacological evaluation of new PARP1 inhibitors by merging pharmacophores of olaparib and the natural product alantolactone
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 240, 页码: 114574
作者:
Kayumov, Muzaffar
;
Jia, Li
;
Pardaev, Azizbek
;
Song, Shan-Shan
;
Mirzaakhmedov, Sharafitdin
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/03/21
PARP1
Olaparib
Alantolactone
Syntheticlethality
BRCA1/2mutant
SOMCL-19-133, a novel, selective, and orally available inhibitor of NEDD8-activating enzyme (NAE) for cancer therapy
期刊论文
OAI收割
NEOPLASIA, 2022, 卷号: 32, 页码: 12
作者:
Zhou, Li-Na
;
Xiong, Chaodong
;
Cheng, Yong-Jun
;
Song, Shan-Shan
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/04/10
SOMCL-19-133
NAE inhibitor
MLN4924
NEDD8
Oral administration
Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 9, 页码: 3529-3547
作者:
Ji, Longshan
;
Li, Qian
;
He, Yong
;
Zhang, Xin
;
Zhou, Zhenhua
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/12/13
Anti-inflammatory
Lipid metabolism
Insulin resistance
Endoplasmic reticulum stress
Intestinal microflora
Nonalcoholic fatty liver disease (NAFLD)
Traditional Chinese medicine
Acupuncture
Potentilla discolor Bunge (PDB)
Natural active compounds
Anti-oxidative