中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [12]
采集方式
OAI收割 [12]
内容类型
期刊论文 [12]
发表日期
2024 [1]
2023 [2]
2022 [2]
2021 [2]
2019 [3]
2018 [1]
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专题:上海药物研究所
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Structure-based optimization of indoline-containing compounds as second generation inhibitors of NF-KB-inducing kinase (NIK)
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1295, 页码: 19
作者:
Cheng, Jing
;
Yan, Ziqin
;
Li, Xinzhi
;
Liu, Chen
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/12/08
Kinase inhibitor
NIK
NF-KB2
Indoline
COT
Cytotoxicity
Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 17
作者:
Yan, Ziqin
;
Lyu, Xilin
;
Lin, Dongze
;
Wu, Gaoxing
;
Gong, Yang
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2023/10/17
Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 11, 页码: 8
作者:
Wang, Junlin
;
Chen, Geng
;
Liao, Qiwen
;
Lyu, Wenping
;
Liu, Aijun
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/04/09
GPCRs
chemerin
adipokine
innate immunity
cryo-EM
Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 236, 页码: 114327
作者:
Feng, Xuexin
;
Yan, Ziqin
;
Zhou, Feilong
;
Lou, Jianfeng
;
Lyu, Xilin
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/03/21
BFL-1
Apoptosis
Covalent inhibitor
Cytochrome c
BCL-2
Protein-Protein interaction
Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 8, 页码: 6207-6230
作者:
Zhang, Shiyan
;
Yan, Ziqin
;
Li, Yafang
;
Gong, Yang
;
Lyu, Xilin
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2022/08/16
Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2021, 卷号: 1241, 页码: 14
作者:
Zhou, Xian
;
Feng, Xuexin
;
Wang, Dachi
;
Chen, Deheng
;
Wu, Gaoxing
  |  
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2021/08/17
Chaetominine
Cellular growth inhibition
Cancer cell line
Covalent warhead
Deleterious mutation V369M in the mouse GCGR gene causes abnormal plasma amino acid levels indicative of a possible liver & ndash;alpha-cell axis
期刊论文
OAI收割
BIOSCIENCE REPORTS, 2021, 卷号: 41, 期号: 6, 页码: 12
作者:
Liu, Qiaofeng
;
Lin, Guangyao
;
Chen, Yan
;
Feng, Wenbo
;
Xu, Yingna
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/11/24
Current trends in drug metabolism and pharmacokinetics
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1113-1144
作者:
Li, Yuhua
;
Meng, Qiang
;
Yang, Mengbi
;
Liu, Dongyang
;
Hou, Xiangyu
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
Pharmacokinetics
Drug metabolism
Drug-drug interactions
Modeling
Metabolizing enzymes
Transporters
Nuclear receptors
Noncoding RNAs
Palladium-catalyzed carbonylative Sonogashira cross-coupling for the synthesis of alkynones with formic acid as the CO source
期刊论文
OAI收割
MONATSHEFTE FUR CHEMIE, 2019, 卷号: 150, 期号: 2, 页码: 309-315
作者:
Lyu, Xue
;
Sun, Guanglong
;
Zhou, Yang
;
Wang, Yingying
;
Lei, Min
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Sonogashira cross-coupling
Aryl iodide
Alkyne
Palladium
Alkynones
currenttrendsindrugmetabolismandpharmacokinetics
期刊论文
OAI收割
actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 6, 页码: 1113
作者:
Liu Dongyang
;
Hou Xiangyu
;
Tang Lan
;
Wang Xin
;
Lyu Yuanfeng
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
ARYL-HYDROCARBON RECEPTOR
BLOOD-BRAIN-BARRIER
ORGANIC ANION TRANSPORTERS
CHRONIC KIDNEY-DISEASE
PREGNANE-X-RECEPTOR
P-GLYCOPROTEIN
QUANTITATIVE PREDICTION
CYTOCHROME-P450 ENZYMES
DOWN-REGULATION
IN-VIVO
Pharmacokinetics
Drug metabolism
Drug-drug interactions
Modeling
Metabolizing enzymes
Transporters
Nuclear receptors
Noncoding RNAs