中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [10]
采集方式
OAI收割 [10]
内容类型
期刊论文 [10]
发表日期
2024 [1]
2023 [4]
2022 [4]
2020 [1]
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专题:上海药物研究所
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Metabolite characterisation of the peptide-drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS
期刊论文
OAI收割
XENOBIOTICA, 2024, 页码: 9
作者:
Yuan, Yali
;
Wang, Weiqiang
;
Luo, Jing
;
Tang, Chongzhuang
;
Zheng, Yuandong
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/02/19
peptide-drug conjugate
PDC
LN005
metabolite identification
liver S9s
A validated LC-MS/MS method for the quantification of bevacizumab in rat, cynomolgus monkey, and human serum
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023, 卷号: 235, 页码: 11
作者:
Zhou, Ainan
;
Yu, Jinghua
;
Wu, Yali
;
Xue, Hao
;
Zhong, Dafang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/10/17
Monoclonal antibody
Bevacizumab
LC-MS
MS
Surrogate peptide
Pharmacokinetics
Serum
Discovery and Structural Optimization of Covalent ZAP-70 Kinase Inhibitors against Psoriasis
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 15
作者:
Rao, Danni
;
Yang, Tao
;
Feng, Huixu
;
An, Qi
;
Zhang, Shaofeng
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/10/17
Discovery of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 15
作者:
Wu, Feifei
;
Li, Huiyu
;
An, Qi
;
Sun, Yaoliang
;
Yu, Jinghua
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/10/17
Hematopoietic progenitor kinase 1 (HPK1)
Cancer immunotherapy
Inhibitor
T cell
Pharmacokinetics,mass balance,and metabolism of 14C TPN171,a novel PDE5 inhibitor,in humans for the treatment of pulmonary arterial hypertension
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 1, 页码: 221
作者:
He Yifei
;
Liu Yin
;
Yu Jinghua
;
Cheng Huan
;
Odilov Abdullajon
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/05/22
TPN171
14CTPN171
PDE5 inhibitor
pulmonary arterial hypertension
healthy volunteers
pharmacokinetics
metabolite identification
mass balance
A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1 beta and IL-6
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 11, 页码: 4180-4192
作者:
Liao, Liping
;
Dang, Wenzhen
;
Lin, Tingting
;
Yu, Jinghua
;
Liu, Tonghai
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2023/04/10
Glycolysis
Phosphoglycerate kinase 1
Macrophages
NRF2
Inflammation
Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2022, 卷号: 50, 期号: 6, 页码: 809-818
作者:
Guo, Zitao
;
Liu, Mengling
;
Meng, Jian
;
Xue, Yaru
;
Huang, Qi
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/08/16
Absorption, metabolism, and excretion of [C-14]YY-20394, a highly selective PI3K-Delta inhibitor in humans
期刊论文
OAI收割
XENOBIOTICA, 2022, 页码: 11
作者:
Yu, Jinghua
;
Zhang, Hua
;
Zhang, Yifan
;
Zhan, Yan
;
Ma, Sheng
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/06/15
YY-20394
[C-14]YY-20394
mass balance
drug metabolism
pharmacokinetics
Absorption, distribution, metabolism, and excretion of [C-14]TPN729 after oral administration to rats
期刊论文
OAI收割
XENOBIOTICA, 2022, 页码: 12
作者:
Cheng, Huan
;
Yu, Jinghua
;
Yang, Chen
;
Zhang, Ning
;
Fan, Zhen
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/06/15
TPN729
[C-14]TPN729
mass balance
tissue distribution
metabolism
Engineering Versatile Nanoparticles for Near-Infrared Light-Tunable Drug Release and Photothermal Degradation of Amyloid beta
期刊论文
OAI收割
ADVANCED FUNCTIONAL MATERIALS, 2020, 页码: 12
作者:
Lai, Yi
;
Zhu, Yingying
;
Xu, Zhiai
;
Hu, Xianli
;
Saeed, Madiha
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/07/01
Alzheimer's disease
amyloid beta
conjugated polymer
light-triggered drug release
photothermal degradation