机构

• 上海药物研究所 [88]

采集方式

• OAI收割 [88]

内容类型

• 期刊论文 [87]
• 会议论文 [1]

发表日期

• 2024 [3]
• 2023 [5]
• 2022 [4]
• 2021 [4]
• 2020 [3]
• 2019 [1]
• 更多

学科主题

• Chemistry [1]

筛选

浏览/检索结果: 共88条，第1-10条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17 作者:  Lan, Yaohan;  Peng, Xia;  Ji, Yinchun;  Su, Yi;  Duan, Wenhu   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/02/27 AXL inhibitor  In vivo antitumor efficacy  6-Naphthyridin-4-one derivatives  Scaffold hopping  Structure-based drug design   Discovery, Optimization, and Evaluation of Novel Pyridin-2(1H)-one Analogues as Potent TRK Inhibitors for Cancer Treatment 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1168-1183 作者:  Xu, Zichao;  Peng, Xia;  Zhang, Renjie;  Ji, Yinchun;  You, Mengke   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/02/27 Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation 期刊论文  OAI收割 JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024, 页码: 13 作者:  Feng, Dazhi;  Liu, Bo;  Chen, Zhiwei;  Xu, Jinyi;  Geng, Meiyu   |  收藏  |  浏览/下载：25/0  |  提交时间：2024/02/27 HPK1 inhibitor  machine learning  virtual screening  free energy perturbation  structural modification   Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933 作者:  Fang, Feifei;  Dai, Yang;  Wang, Hao;  Ji, Yinchun;  Liang, Xuewu   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/01/26 derivatives  Antitumor drug development  Potential AXL inhibitor  Antitumor activity  Structure-based drug design  Fused-pyrazolone carboxamide   Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 23, 页码: 16201-16221 作者:  Xie, Chenghu;  Liu, Bo;  Song, Zilan;  Yang, Ye;  Dai, Mengdi   |  收藏  |  浏览/下载：17/0  |  提交时间：2024/02/27 The heparan sulfate mimetic Muparfostat aggravates steatohepatitis in obese mice due to its binding affinity to lipoprotein lipase 期刊论文  OAI收割 BRITISH JOURNAL OF PHARMACOLOGY, 2023, 卷号: 180, 期号: 14, 页码: 1803-1818 作者:  Zhang, Jia;  Li, Kai;  Sun, Hao-Ran;  Sun, Shao-Kun;  Zhu, Ya-Ting   |  收藏  |  浏览/下载：4/0  |  提交时间：2024/03/27 heparan sulfate mimetic  heparanase inhibitor  hepatic steatosis  lipoprotein lipase  obesity   A study on optical properties of various hot drug molecules by 2020 期刊论文  OAI收割 NEW JOURNAL OF CHEMISTRY, 2023, 卷号: 47, 期号: 21, 页码: 10046-10060 作者:  Zhang, Chun;  Yang, Yuting;  Yan, Xue;  Sun, Yi-Tao;  Shao, Andong   |  收藏  |  浏览/下载：15/0  |  提交时间：2023/10/17 SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer 期刊论文  OAI收割 SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 卷号: 8, 期号: 1, 页码: 13 作者:  Zhou, Ji;  Zhang, Xu-Chao;  Xue, Shan;  Dai, Mengdi;  Wang, Yueliang   |  收藏  |  浏览/下载：12/0  |  提交时间：2023/10/17 Targeting the PI3K/AKT/mTOR Signaling Pathway in the Treatment of Human Diseases: Current Status, Trends, and Solutions 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 29 作者:  Huang, Jindi;  Chen, Liye;  Wu, Jiangxia;  Ai, Daiqiao;  Zhang, Ji-Quan   |  收藏  |  浏览/下载：19/0  |  提交时间：2023/04/10 Discovery of 3-Aminopyrazole Derivatives as New Potent and Orally Bioavailable AXL Inhibitors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 22, 页码: 15374-15390 作者:  Chan, Shingpan;  Zhang, Yunong;  Wang, Jie;  Yu, Qiuchun;  Peng, Xia   |  收藏  |  浏览/下载：16/0  |  提交时间：2023/04/10