中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [12]
采集方式
OAI收割 [12]
内容类型
期刊论文 [12]
发表日期
2023 [2]
2021 [2]
2018 [1]
2017 [2]
2015 [3]
2014 [1]
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学科主题
Chemistry [1]
Pharmacolo... [1]
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专题:上海药物研究所
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Development of HSP90 inhibitors-SN38 conjugates for cancer treatment
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 137, 页码: 11
作者:
Cao, Yuting
;
Shen, Qianqian
;
Ding, Mengyuan
;
Chen, Yi
;
Lu, Wei
  |  
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2023/10/17
HSP90
SN38 conjugate
Drug accumulation
Cancer treatment
Cell membrane-coated mesoporous silica nanorods overcome sequential drug delivery barriers against colorectal cancer
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2023, 卷号: 34, 期号: 6, 页码: 6
作者:
Wang, Jie
;
Pan, Hao
;
Li, Jingyi
;
Nie, Di
;
Zhuo, Yan
  |  
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2023/10/17
Cell membrane coating
Rod shape
Sequential delivery
Nuclear accumulation
Colorectal cancer
GADD45 beta stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation
期刊论文
OAI收割
PHARMACOLOGICAL RESEARCH, 2021, 卷号: 173, 页码: 11
作者:
Dong, Yunxia
;
Ma, Ningning
;
Fan, Lei
;
Yuan, Luyang
;
Wu, Qian
  |  
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2021/12/16
Non-alcoholic fatty liver disease
GADD45 beta
HSP72
Lipid accumulation
Insulin resistance
A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage
期刊论文
OAI收割
METABOLISM-CLINICAL AND EXPERIMENTAL, 2021, 卷号: 120, 页码: 12
作者:
Huang, Suling
;
Wu, Yanwei
;
Zhao, Zhuohui
;
Wu, Bing
;
Sun, Kai
  |  
收藏
  |  
浏览/下载:107/0
  |  
提交时间:2021/08/17
Macrophage
NLRP3 inflammasome
Hepatic lipid accumulation
NASH
FXR
Optimal extraction of Phaeoporus obliquus saponins and its scavenging effect on fat accumulation in HepG2 cells
期刊论文
OAI收割
Journal of Jilin Univeristy. Medicine edition, 2018, 卷号: 44, 期号: 3, 页码: 526-531
作者:
Zhang Lei
;
Zhang Kun
;
Wang Deli
;
Ren Xiaohong
;
Cui Na
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Phaeoporus obliquus
saponins
HepG2 cells
triglyceride
fat accumulation
Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse nonalcoholic steatohepatitis
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 5, 页码: 660-671
作者:
Liu, Ming-xia
;
Gao, Man
;
Li, Chun-zhu
;
Yu, Cun-zhi
;
Yan, Hong
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2019/01/08
non-alcoholic steatohepatitis
cholesterol accumulation
Dicer1
HMGCR
microRNA-29
MCD diet-treated mice
SH2B1 is Involved in the Accumulation of Amyloid-beta(42) in Alzheimer's Disease
期刊论文
OAI收割
JOURNAL OF ALZHEIMERS DISEASE, 2017, 卷号: 55, 期号: 2, 页码: 835-847
作者:
Shen, Yijun
;
Xia, Yiling
;
Meng, Shiquan
;
Lim, Nastasia K. H.
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2019/01/08
Alzheimer's disease
amyloid-beta accumulation
diabetes
SH2B1 protein
2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b] thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 4, 页码: 483-496
作者:
Zhang, Jin
;
Zhang, Li-na
;
Chen, Dong-mei
;
Fu, Yan-yun
;
Zhang, Feng
  |  
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/01/08
2-(3-benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b] thiophene-3-carboxylic acid
lipogenesis
SREBP-1c
AMPK
mTOR
hepatic lipid accumulation
obesity
metabolic disorders
23benzoylthioureido4567tetrahydrobenzobthiophene3carboxylicacidamelioratesmetabolicdisordersinhighfatdietfedmice
期刊论文
OAI收割
actapharmacologicasinica, 2015, 卷号: 36, 期号: 4, 页码: 483
作者:
Zhang Jin
;
Zhang Lina
;
Chen Dongmei
;
Fu Yanyun
;
Zhang Feng
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
ACTIVATED PROTEIN-KINASE
ELEMENT-BINDING PROTEIN-1C
INSULIN-RESISTANCE
LIVER-DISEASE
TRANSCRIPTION FACTOR
DIABETES-MELLITUS
HEPATIC STEATOSIS
CULTURED-CELLS
SREBP ACTIVITY
DIRECT TARGET
2-(3-benzoylthioureido)-4,5,6,7-tetrahydrobenzob thiophene-3-carboxylic acid
lipogenesis
SREBP-1c
AMPK
mTOR
hepatic lipid accumulation
obesity
metabolic disorders
Proteomic and bioinformatic analyses of possible targetrelated proteins of gambogic acid in human breast carcinoma MDA-MB-231 cells
期刊论文
OAI收割
Chinese Journal of Natural Medicines, 2015, 卷号: 13, 期号: 1, 页码: 41
作者:
Li Dong
;
Song Xiaoyi
;
Yue Qingxi
;
Cui Yajun
;
Liu Miao
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/07/01
INDUCED APOPTOSIS
INHIBITS ANGIOGENESIS
UP-REGULATION
CYCLE ARREST
CANCER-CELLS
PHOSPHORYLATION
ACCUMULATION
DEGRADATION
RESISTANCE
MECHANISM
Gambogic acid
MDA-MB-231 cells
Anti-cancer
Proteomic
Bioinformatic