中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [29]
采集方式
OAI收割 [29]
内容类型
期刊论文 [29]
发表日期
2022 [29]
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发表日期:2022
专题:上海药物研究所
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Optimized Synthesis of a Key Intermediate of Nirmatrelvir
期刊论文
OAI收割
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2022, 页码: 6
作者:
Qin, Hongjian
;
Jin, Chen
;
Odilov, Abdullajon
;
Bonku, Emmanuel Mintah
;
Zhu, Fuqiang
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/04/10
alpha-cyanomethylation
neodymium chloride
hydrogenation
one-pot
cyclic glutamine analog
Nirmatrelvir
Investigation of atropisomeric transformation of a novel PDE4 inhibitor with tetrahydroisoquinoline-based amide group and its primary study of binding to HSA
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2022, 卷号: 221, 页码: 5
作者:
Chen, Huanhuan
;
Zhu, Tingfei
;
Sun, Ling
;
Xiang, Lili
;
Han, Haiyun
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2023/04/10
Atropisomer
Restricted rotation
Kinetic
Energy barrier
Dynamic HPLC
HSA binding
Authentication of herbal medicines from multiple botanical origins with cross-validation mebabolomics, absolute quantification and support vector machine model, a case study of Rhizoma Alismatis
期刊论文
OAI收割
ARABIAN JOURNAL OF CHEMISTRY, 2022, 卷号: 15, 期号: 10, 页码: 8
作者:
Zhang, Jianqing
;
Wang, Cuicui
;
Wu, Wenyong
;
Jin, Qinghao
;
Wu, Jia
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2022/12/13
Rhizoma Alismatis
Alisma plantago-aquatica
Alisma orientale
Botanical origins
UHPLC/Orbitrap-MS
Ethyl Acetate Extract of Dracocephalum heterophyllum Benth Ameliorates Nonalcoholic Steatohepatitis and Fibrosis via Regulating Bile Acid Metabolism, Oxidative Stress and Inhibiting Inflammation
期刊论文
OAI收割
SEPARATIONS, 2022, 卷号: 9, 期号: 10, 页码: 24
作者:
Fang, Yan
;
Sun, Dandan
;
Li, Gang
;
Lv, Yue
;
Li, Jia
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/12/13
Dracocephalum heterophyllum benth
preparative separation
nonalcoholic steatohepatitis
liver fibrosis
molecular docking
Current Analytical Strategies for Antibody-Drug Conjugates in Biomatrices
期刊论文
OAI收割
MOLECULES, 2022, 卷号: 27, 期号: 19, 页码: 17
作者:
Qin, Qiuping
;
Gong, Likun
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/11/11
ADC
antibody
payload
LBA
LC-MS
bioanalysis
immunogenicity
interference
Determination of six core components from Mahuang Xuanfei Zhike syrup in rat plasma and tissues by UPLC-MS/MS: Application to a pharmacokinetics and tissue distribution study
期刊论文
OAI收割
BIOMEDICAL CHROMATOGRAPHY, 2022, 页码: 15
作者:
Yang, Yang
;
Zhu, Jing
;
Yao, Chang-liang
;
Guo, De-an
;
He, Na
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/11/11
Mahuang Xuanfei Zhike syrup
pharmacokinetics
tissue distribution
UPLC-MS
MS
Integrating UPLC-HR-MS/MS, Network Pharmacology, and Experimental Validation to Uncover the Mechanisms of Jin?gan Capsules against Breast Cancer br
期刊论文
OAI收割
ACS OMEGA, 2022, 卷号: 7, 期号: 32, 页码: 28003-28015
作者:
Qiu, Jianfei
;
Zhang, Zhiyin
;
Hu, Anling
;
Zhao, Peng
;
Wei, Xuenai
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/09/30
Integrating UPLC-HR-MS/MS, Network Pharmacology, and Experimental Validation to Uncover the Mechanisms of Jin'gan Capsules against Breast Cancer
期刊论文
OAI收割
ACS OMEGA, 2022, 页码: 13
作者:
Qiu, Jianfei
;
Zhang, Zhiyin
;
Hu, Anling
;
Zhao, Peng
;
Wei, Xuenai
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/09/30
Novel assays for quality evaluation of XueBiJing: Quality variability of a Chinese herbal injection for sepsis management
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL ANALYSIS, 2022, 卷号: 12, 期号: 4, 页码: 664-682
作者:
Yu, Xuan
;
Niu, Wei
;
Wang, Ya-Ya
;
Olaleye, Olajide E.
;
Wang, Jia-Nan
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/11/11
XueBiJing
Chinese herbal medicine
Quality variability
Quality marker
One -point calibration
Practical and Highly Efficient Synthesis of Remdesivir from GS-441524
期刊论文
OAI收割
ACS OMEGA, 2022, 页码: 7
作者:
Hu, Tianwen
;
Zhu, Fuqiang
;
Xiang, Li
;
Shen, Jingshan
;
Xie, Yuanchao
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2022/08/30