中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [492]
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期刊论文 [1976]
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Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase
期刊论文
OAI收割
ACS CHEMICAL BIOLOGY, 2024, 页码: 12
作者:
Zhang, Huimin
;
Xu, Dounan
;
Huang, Hongchan
;
Jiang, Hao
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
Complex
N
-glycans are important for interspecies transmission of H7 influenza A viruses
期刊论文
OAI收割
JOURNAL OF VIROLOGY, 2024, 页码: 21
作者:
Spruit, Cindy M.
;
Palme, Diana I.
;
Li, Tiehai
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/05/07
influenza A virus
hemagglutinin
interspecies transmission
sialyl-LewisX
NeuGc
Spatiotemporal Quantification of HER2-targeting Antibody-Drug Conjugate Bystander Activity and Enhancement of Solid Tumor Penetration
期刊论文
OAI收割
CLINICAL CANCER RESEARCH, 2024, 卷号: 30, 期号: 5, 页码: 984-997
作者:
Wei, Qing
;
Yang, Teng
;
Zhu, Jiayu
;
Zhang, Ziwen
;
Yang, Le
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G
s
proteins
期刊论文
OAI收割
CELL DISCOVERY, 2024, 卷号: 10, 期号: 1, 页码: 13
作者:
Cong, Zhaotong
;
Zhao, Fenghui
;
Li, Yang
;
Luo, Gan
;
Mai, Yiting
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2024/03/13
Molecular Insights into O-Linked Sialoglycans Recognition by the Siglec-Like SLBR-N (SLBR
UB10712
) of Streptococcus gordonii
期刊论文
OAI收割
ACS CENTRAL SCIENCE, 2024, 卷号: 10, 期号: 2, 页码: 447-459
作者:
Di Carluccio, Cristina
;
Cerofolini, Linda
;
Moreira, Miguel
;
Rosu, Frederic
;
Padilla-Cortes, Luis
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/05/07
Application of ensemble learning for predicting GABA
A
receptor agonists
期刊论文
OAI收割
COMPUTERS IN BIOLOGY AND MEDICINE, 2024, 卷号: 169, 页码: 13
作者:
Xiao, Fu
;
Ding, Xiaoyu
;
Shi, Yan
;
Wang, Dingyan
;
Wang, Yitian
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/03/25
GABA(A )receptor
Benzodiazepine
Agonist
Machine learning
Classification
Transfer learning enhanced graph neural network for aldehyde oxidase metabolism prediction and its experimental application
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 2, 页码: 623-634
作者:
Xiong, Jiacheng
;
Cui, Rongrong
;
Li, Zhaojun
;
Zhang, Wei
;
Zhang, Runze
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
Drug metabolism
Aldehyde oxidase
Transfer learning
Graph neural network
Kinase inhibitor
Structure-based development of potent and selective type-II kinase inhibitors of RIPK1
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334
作者:
Qin, Ying
;
Li, Dekang
;
Qi, Chunting
;
Xiang, Huaijiang
;
Meng, Huyan
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/03/06
RIPK1
Necroptosis
Type-II kinase inhibitors
Rational design
Lead optimization
Structure-activity relationship
Anti-inflammation
Preclinical drug discovery
DNA Aptamer Binding Octapeptide Repeat Region of Cellular Prion Protein
期刊论文
OAI收割
ANALYTICAL CHEMISTRY, 2023, 卷号: 95, 期号: 50, 页码: 18595-18602
作者:
Sheng, Jing
;
Zhang, Nan
;
Long, Zhenhao
;
Zhang, Xiangru
;
Zu, Shuang
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/01/26
Exploring the mechanism of the PTP1B inhibitors by molecular dynamics and experimental study
期刊论文
OAI收割
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2023, 卷号: 125, 页码: 12
作者:
Zhao, Tian-Tian
;
Hu, Hao-Jie
;
Gao, Li-Xin
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/10/17
Protein tyrosine phosphatases inhibitors
PTP1B inhibitors
Mechanism study
Molecular dynamics