中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Conference report for the 10th China Bioanalysis Forum annual meeting
期刊论文
OAI收割
BIOANALYSIS, 2023, 页码: 4
作者:
Dong, Kelly
;
Zhu, Mingshe
;
Tang, Daniel
;
Jin, Fan
;
Zhong, Dafang
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2023/12/19
China Bioanalysis Forum
CBF
ICH M10
DMPK and Bioanalysis for New Modalities
Simultaneous quantification of 3 ',4 '-dimethoxy flavonol-3-O-glucoside and its major metabolite in human plasma by LC-MS/MS and its application to a clinical pharmacokinetic study
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023, 卷号: 225, 页码: 9
作者:
Wang, Lu
;
Shen, Haifeng
;
Zhan, Yan
;
Zhang, Yifan
;
Zhang, Yong
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2023/04/10
3?4?-Dimethoxy flavonol-3-O-glucoside
Aglycone glucuronide
LC-MS
MS
Human pharmacokinetic study
Development and validation of a LC-MS/MS method for quantitation of recombinant human growth hormone in rat plasma and application to a pharmacokinetic study
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023, 卷号: 224, 页码: 9
作者:
Huang, Wen-si
;
Yu, Jing-hua
;
Diao, Xing-xing
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/04/10
Recombinant human growth hormone (rhGH)
Somatotropin
Method validation
LC-MS
MS
Pharmacokinetics
Pharmacokinetics,mass balance,and metabolism of 14C TPN171,a novel PDE5 inhibitor,in humans for the treatment of pulmonary arterial hypertension
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 1, 页码: 221
作者:
He Yifei
;
Liu Yin
;
Yu Jinghua
;
Cheng Huan
;
Odilov Abdullajon
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/05/22
TPN171
14CTPN171
PDE5 inhibitor
pulmonary arterial hypertension
healthy volunteers
pharmacokinetics
metabolite identification
mass balance
Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties
期刊论文
OAI收割
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 1537-1555
作者:
Li, Ennian
;
Wang, Kai
;
Zhang, Bei
;
Guo, Siqi
;
Xiao, Senhao
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/08/16
DNMT1 inhibitor
A549 cell lines
HCT116 cell lines
antitumor activity
pharmacokinetic
In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2
期刊论文
OAI收割
ANTIVIRAL RESEARCH, 2022, 卷号: 208, 页码: 10
作者:
Shang, Weijuan
;
Dai, Wenhao
;
Yao, Cheng
;
Xu, Ling
;
Tao, Xiangming
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2023/04/10
SARS-CoV-2
SARS-CoV-2 variants
FB2001
Main protease
PBPK
Anti-SARS-CoV-2 in vivo
Mesenchymal Stem Cell Fates in Murine Acute Liver Injury and Chronic Liver Fibrosis Induced by Carbon Tetrachloride
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2022, 卷号: 50, 期号: 10, 页码: 1352-1360
作者:
Ma, Chenhui
;
Han, Li
;
Wu, Jiajun
;
Tang, Feng
;
Deng, Qiangqiang
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2023/04/10
SOMCL-19-133, a novel, selective, and orally available inhibitor of NEDD8-activating enzyme (NAE) for cancer therapy
期刊论文
OAI收割
NEOPLASIA, 2022, 卷号: 32, 页码: 12
作者:
Zhou, Li-Na
;
Xiong, Chaodong
;
Cheng, Yong-Jun
;
Song, Shan-Shan
;
Bao, Xu-Bin
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2023/04/10
SOMCL-19-133
NAE inhibitor
MLN4924
NEDD8
Oral administration
Qualitative and quantitative determination of the primary active components and metabolites in human plasma after oral administration of Shuanghuanglian liquid
期刊论文
OAI收割
JOURNAL OF SEPARATION SCIENCE, 2022, 页码: 12
作者:
Zhang, Shengman
;
Liu, Ying
;
Peng, Ni
;
Chen, Xiaoyan
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2022/08/16
baicalin
chlorogenic acid
forsythin
liquid chromatography-tandem mass spectrometry
Shuanghuanglian liquid
Pharmacokinetics, mass balance, and metabolism of [C-14]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13
作者:
He, Yi-fei
;
Liu, Yin
;
Yu, Jing-hua
;
Cheng, Huan
;
Odilov, Abdullajon
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2022/08/16
TPN171
[C-14]TPN171
PDE5 inhibitor
pulmonary arterial hypertension
healthy volunteers
pharmacokinetics
metabolite identification
mass balance