中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [119]
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期刊论文 [668]
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Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 12
作者:
Zou, Zhi-feng
;
Yang, Lei
;
Nie, Hui-jun
;
Gao, Jing
;
Lei, Shu-min
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/05/22
proteolysis-targeting chimeras
tumor-targeted delivery
precise protein degradation
combination therapy
triple-negative breast cancer
Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to regulate miRNA biogenesis and lipid metabolism
期刊论文
OAI收割
LIVER INTERNATIONAL, 2024, 页码: 17
作者:
Hou, Aijun
;
Xu, Xiaoding
;
Zhang, Yu
;
He, Hongxiu
;
Feng, Yihan
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
Drosha degradation
lipid metabolism
miRNA biogenesis
NAFLD
PRMT5
Reversible SAHH inhibitor ameliorates MIA-induced osteoarthritis of rats through suppressing MEK/ERK pathway
期刊论文
OAI收割
BIOMEDICINE & PHARMACOTHERAPY, 2024, 卷号: 170, 页码: 6
作者:
Fan, Shu-Hui
;
Chang, Yuan
;
Xiong, Xiao-Yu
;
Xiang, Mai
;
Yuan, Wen-Long
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/02/27
DZ2002
Osteoarthritis
Osteoclast
Bone resorption
Targeting ST8SIA6-AS1 counteracts KRAS
G12C
inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling
期刊论文
OAI收割
EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2023, 卷号: 12, 期号: 1, 页码: 22
作者:
Wang, Yafang
;
Yao, Mingyue
;
Li, Cheng
;
Yang, Kexin
;
Qin, Xiaolong
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/01/26
KRAS(G12C)
c-Myc
PLK1
LncRNA
ST8SIA6-AS1
Drug resistance
Structure-based identification of new orally bioavailable BRD9-PROTACs for treating acute myelocytic leukemia
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 18
作者:
Zhang, Jingyu
;
Duan, Haiting
;
Gui, Renzhao
;
Wu, Mingfei
;
Shen, Liteng
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/12/19
Acute myeloid leukemia
Bromodomain-containing protein 9
Proteolysis-targeting chimera
Orally bioavailable
Docking
Preparation of Multifunctional Seaweed Polysaccharides Derivatives Composite Hydrogel to Protect Ultraviolet B-Induced Photoaging In Vitro and In Vivo
期刊论文
OAI收割
MACROMOLECULAR BIOSCIENCE, 2023, 页码: 16
作者:
Wu, Yumeng
;
Geng, Lihua
;
Zhang, Jingjing
;
Wu, Ning
;
Yang, Yue
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/04/07
alginate oligosaccharides
multifunctional composite hydrogel
photoaging
sulfated galactofucan polysaccharides
ultraviolet B
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation
期刊论文
OAI收割
CELL CHEMICAL BIOLOGY, 2023, 卷号: 30, 期号: 11, 页码: 1421-+
作者:
Xiao, Yufeng
;
Hale, Seth
;
Awasthee, Nikee
;
Meng, Chengcheng
;
Zhang, Xuan
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/01/16
Proteasome inhibitors reduce CD73 expression partly
via
decreasing p-ERK in NSCLC cells
期刊论文
OAI收割
LIFE SCIENCES, 2023, 卷号: 332, 页码: 10
作者:
Su, Ai-Ling
;
Tian, Chang-Qing
;
Ou, Ying-Jie
;
Bao, Xu-Bin
;
Huan, Xia-Juan
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/12/08
CD73
Proteasome inhibitors
ERK
NSCLC
LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter
期刊论文
OAI收割
BMC CANCER, 2023, 卷号: 23, 期号: 1, 页码: 20
作者:
Ren, Ganglin
;
Li, Hongyan
;
Hong, Dan
;
Hu, Fangyu
;
Jin, Rongjia
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/12/08
LINC00955
Colorectal cancer
Cell cycle
CDK2
PHIP
Sp1
Hepatic glucuronyl C5-epimerase combats obesity by stabilising GDF15
期刊论文
OAI收割
JOURNAL OF HEPATOLOGY, 2023, 卷号: 79, 期号: 3, 页码: 14
作者:
He, Fei
;
Jiang, Haowen
;
Peng, Chang
;
Wang, Tingting
;
Xiao, Rongrong
  |  
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2023/10/17
Glucuronyl C5-epimerase
Growth differentiation factor-15
Obesity
Energy expenditure
Ubiquitination