中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [71]
新疆理化技术研究所 [4]
成都山地灾害与环境研... [1]
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OAI收割 [79]
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期刊论文 [79]
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2025 [1]
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浏览/检索结果:
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Discovery of peptidomimetic spiropyrrolidine derivatives as novel 3CLpro inhibitors against SARS-CoV-2
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 281, 页码: 22
作者:
Guma, Samuel Desta
;
Zhou, Zhaoyin
;
Song, Kang
;
Yang, Feipu
;
Suo, Jin
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/12/11
SARS-CoV-2
3CL pro inhibitors
Peptidomimetics
Spiropyrrolidine derivatives
F-CPI: A Multimodal Deep Learning Approach for Predicting Compound Bioactivity Changes Induced by Fluorine Substitution
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 13
作者:
Zhang, Qian
;
Yin, Wenhai
;
Chen, Xinyao
;
Zhou, Aimin
;
Zhang, Guixu
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/02/28
Direct Reductive
N
-alkylation of Amines with Carboxylic Esters
期刊论文
OAI收割
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2024, 页码: 7
作者:
Zhang, Yuxuan
;
Bonku, Emmanuel Mintah
;
Yang, Xingbang
;
Zhu, Fuqiang
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/01/14
Direct reductive
N
-alkylation of amine
One-pot reaction
Grignard reagent
Amidation of ester
Cariprazine
Design, synthesis, and evaluation of novel oxyacanthine derivatives for anti-SARS-CoV-2 activity
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 113, 页码: 5
作者:
Lu, Jie
;
Cheng, Yan
;
Zhang, Yumin
;
Wang, Yi
;
Xia, Bingqing
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/02/28
Bisbenzylisoquinoline alkaloid
Oxyacanthine derivatives
SARS-CoV-2
Discovery of the potent covalent inhibitor with an acrylate warhead for SARS-CoV-2 3CL protease
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 112, 页码: 5
作者:
Shen, Wen
;
Chen, Xinyao
;
Zhou, Liping
;
Cheng, Yan
;
Zhang, Yan
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/10/21
COVID-19
SARS-CoV-2 3CL pro inhibitor
Drug design
Antiviral activities
Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 6, 页码: 4855-4869
作者:
Gu, Chenming
;
Liu, Jiayuan
;
Qian, Fei
;
Yu, Wenchao
;
Huang, Doudou
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/05/07
TPN10475 Constrains Effector T Lymphocytes Activation and Attenuates Experimental Autoimmune Encephalomyelitis Pathogenesis by Facilitating TGF-β Signal Transduction
期刊论文
OAI收割
JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2024, 卷号: 19, 期号: 1, 页码: 16
作者:
Wang, Chun
;
Jiang, Xiangrui
;
Lv, Jie
;
Zhuang, Wei
;
Xie, Ling
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2024/04/09
Experimental autoimmune encephalomyelitis
TGF-beta signal transduction
Effector CD4(+) T cells activation
Th/Treg
Cell migration
Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 20
作者:
Yang, Wenjiao
;
Gong, Xudong
;
Sun, Haiguo
;
Wu, Chunhui
;
Suo, Jin
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/03/06
CB2R agonist
5-HT1AR agonist
CB1R antagonist
Antidepressant
Anxiolytic
Dual-channel hypergraph convolutional network for predicting herb-disease associations
期刊论文
OAI收割
BRIEFINGS IN BIOINFORMATICS, 2024, 卷号: 25, 期号: 2, 页码: 13
作者:
Hu, Lun
;
Zhang, Menglong
;
Hu, Pengwei
;
Zhang, Jun
;
Niu, Chao
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/08/22
herb-disease association prediction
network pharmacology
hypergraph convolutional network
multi-target multi-component
Chinese traditional medicine
Glimepiride, a novel soluble epoxide hydrolase inhibitor, protects against heart failure via increasing epoxyeicosatrienoic acids
期刊论文
OAI收割
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2023, 卷号: 185, 页码: 13-25
作者:
Zhao, Chengcheng
;
Jiang, Xiangrui
;
Peng, Liyuan
;
Zhang, Yan
;
Li, Huihui
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2024/01/16
Heart failure
Hypertrophy
Epoxyeicosatrienoic acids
Soluble epoxide hydrolase