中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [58]
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期刊论文 [545]
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One stone two birds: Introducing piperazine into a series of nucleoside derivatives as potent and selective PRMT5 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 281, 页码: 18
作者:
Li, Huaxuan
;
Yang, Hong
;
Liu, Li
;
Zheng, Jiahong
;
Shi, Qiongyu
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/12/11
Protein arginine methyltransferase 5
Nucleoside derivatives
Piperazine
Metabolic stability
Symmetric dimethylarginines
Emerging Pollutants
期刊论文
OAI收割
PROGRESS IN CHEMISTRY, 2024, 卷号: 36, 期号: 11, 页码: 1607-1784
作者:
Wang, Yawei
;
Zhang, Qiurui
;
Yu, Nanyang
;
Wang, Yuan
;
Wei, Si
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/04/03
emerging pollutants
occurrence level
environmental behavior
ecological risks
control strategies
Discovery of CZL-046 with an (
S
)-3-Fluoropyrrolidin-2-one Scaffold as a p300 Bromodomain Inhibitor for the Treatment of Multiple Myeloma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 20, 页码: 18606-18628
作者:
Chen, Zonglong
;
Yang, Hong
;
Zhang, Yan
;
Lyu, Xiaodong
;
Shi, Qiongyu
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/11/05
Transcriptomic decoding of regional cortical vulnerability to major depressive disorder
期刊论文
OAI收割
COMMUNICATIONS BIOLOGY, 2024, 卷号: 7, 期号: 1, 页码: 12
作者:
Zhu, Jiajia
;
Chen, Xiao
;
Lu, Bin
;
Li, Xue-Ying
;
Wang, Zi-Han
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/09/10
Efficacy, safety and biomarkers of SG001 for patients with previously treated recurrent or metastatic cervical cancer: an open-label, multicenter, phase Ib trial
期刊论文
OAI收割
CANCER COMMUNICATIONS, 2024
作者:
Zuo, Jing
;
Duan, Wei
;
Zhao, Mingxuan
;
Chen, Zhendong
;
Lin, Jie
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/11/22
Targeting CCL2-CCR2 signaling pathway alleviates macrophage dysfunction in COPD via PI3K-AKT axis
期刊论文
OAI收割
CELL COMMUNICATION AND SIGNALING, 2024, 卷号: 22, 期号: 1, 页码: 19
作者:
Dong, Yue
;
Dong, Ying
;
Zhu, Chengyue
;
Yang, Lan
;
Wang, Hanlin
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/08/22
Chronic obstructive pulmonary disease
C-C motif chemokine ligand 2
C-C chemokine receptor type 2
Bronchial epithelial cells
Macrophage
FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 15
作者:
Wen, Ying-quan
;
Zou, Zi-yuan
;
Zhao, Guan-guan
;
Zhang, Meng-jiao
;
Zhang, Yong-xin
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/08/22
MASLD/MASH
FXR
transcriptome
gut-liver axis
agonist
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 13
作者:
Yang, Ying
;
Suo, Na
;
Cui, Shi-hao
;
Wu, Xuan
;
Ren, Xin-yue
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/07/12
oligodendrocyte differentiation
oligodendrocyte progenitor cell
remyelination
trametinib
MEK inhibitor
MEK/ERK pathway
Cross-ancestry genome-wide association studies of brain imaging phenotypes
期刊论文
OAI收割
NATURE GENETICS, 2024, 页码: 31
作者:
Fu, Jilian
;
Zhang, Quan
;
Wang, Jianhua
;
Wang, Meiyun
;
Zhang, Bing
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/06/29
A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM
期刊论文
OAI收割
CELL DISCOVERY, 2024, 卷号: 10, 期号: 1, 页码: 4
作者:
Chen, Yanyan
;
Li, Yang
;
Zhou, Qingtong
;
Cong, Zhaotong
;
Lin, Shi
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/06/27