机构

• 上海药物研究所 [9]
• 宁波材料技术与工程研... [2]

采集方式

• OAI收割 [11]

内容类型

• 期刊论文 [10]
• 会议论文 [1]

发表日期

• 2022 [1]
• 2021 [1]
• 2019 [1]
• 2018 [2]
• 2016 [2]
• 2014 [2]
• 更多

学科主题

• Chemistry [1]
• Materials ... [1]
• Physics [1]

筛选

浏览/检索结果: 共11条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Design and exploration of gut-restricted bifunctional molecule with TGR5 agonistic and DPP4 inhibitory effects for treating ulcerative colitis 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 242, 页码: 114697 作者:  Han, Fanghui;  Ning, Mengmeng;  Wang, Kai;  Gu, Yipei;  Qu, Hui   |  收藏  |  浏览/下载：26/0  |  提交时间：2024/03/21 Bifunctional molecule  Gut-restricted  Ulcerative colitis  TGR5  DPP4   Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:  Li, Teng-teng;  Peng, Cheng;  Wang, Ji-qiu;  Xu, Zhi-jian;  Su, Ming-bo   |  收藏  |  浏览/下载：76/0  |  提交时间：2022/01/18 DPP4  distal mutation  enzymatic activity  molecular dynamics simulation  structure-function mechanism   Alogliptin alleviates liver fibrosis via suppression of activated hepatic stellate cell 期刊论文  OAI收割 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 511, 期号: 2, 页码: 387-393 作者:  Zhang, Hanyan;  Sun, Dandan;  Wang, Guanzhen;  Cui, Shichao;  Field, Robert A.   |  收藏  |  浏览/下载：25/0  |  提交时间：2020/07/01 DPP4  Alogliptin  Liver fibrosis  Hepatic stellate cell   A novel non-enzymatic hydrolytic probe for dipeptidyl peptidase IV specific recognition and imaging 期刊论文  OAI收割 CHEMICAL COMMUNICATIONS, 2018, 卷号: 54, 期号: 63, 页码: 8773-8776 作者:  Sun, Shan;  Wu, Aiguo;  Xing, Jie;  Gong, Qiuyu;  Zhang, Renshuai   |  收藏  |  浏览/下载：223/0  |  提交时间：2018/12/04 Fibroblast Activation Protein  Fluorescence Probes  Inhibitors  Cells  Mechanisms  Enzyme  Potent  Vitro  Dpp4  Vivo   A novel non-enzymatic hydrolytic probe for dipeptidyl peptidase IV specific recognition and imaging 会议论文  OAI收割 作者:  Xing, Jie;  Gong, Qiuyu;  Zhang, Renshuai;  Sun, Shan;  Zou, Ruifen   |  收藏  |  浏览/下载：17/0  |  提交时间：2021/12/02 FIBROBLAST ACTIVATION PROTEIN  FLUORESCENCE PROBES  RECEPTOR-BINDING  DPP4  POTENT  VITRO  VIVO   OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 10, 页码: 1359-1369 作者:  Ma, Shan-yao;  Ning, Meng-meng;  Zou, Qing-an;  Feng, Ying;  Ye, Yang-liang   |  收藏  |  浏览/下载：40/0  |  提交时间：2019/01/08 OL3  MN6  linagliptin  TGR5 agonist  DPP4 inhibitor  GLP-1  low-absorbed  gallbladder filling  type 2 diabetes mellitus   ol3anovellowabsorbedtgr5agonistwithreducedsideeffectsloweredbloodglucoseviadualactionsontgr5activationanddpp4inhibition 期刊论文  OAI收割 actapharmacologicasinica, 2016, 卷号: 000, 期号: 010, 页码: 1359 作者:  Ma Shanyao;  Ning Mengmeng;  Zou Qingan;  Feng Ying;  Ye Yangliang   |  收藏  |  浏览/下载：17/0  |  提交时间：2020/07/01 OL3  MN6  linagliptin  TGR5 agonist  DPP4 inhibitor  GLP-1  low-absorbed  gallbladder filling  type 2 diabetes mellitus   Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 86, 页码: 242-256 作者:  Ji, Xun;  Xia, Chunmei;  Wang, Jiang;  Su, Mingbo;  Zhang, Lei   |  收藏  |  浏览/下载：102/0  |  提交时间：2019/01/08 DPP4 inhibitors  GLP-1  Selectivity  Oral bioavailability  Oral glucose tolerance tests  hERG   Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 75, 页码: 111-122 作者:  Ji, Xun;  Su, Mingbo;  Wang, Jiang;  Deng, Guanghui;  Deng, Sisi   |  收藏  |  浏览/下载：93/0  |  提交时间：2019/01/08 DPP4 inhibitors  Selectivity  Reversible kinetic characterization  Oral bioavailability  Oral glucose tolerance test   基于西他列汀及其衍生物的抗Ⅱ型糖尿病药物分子3D-QSAR和分子对接研究(英文) 期刊论文  OAI收割 计算机与应用化学, 2011, 卷号: 28, 期号: 06, 页码: 666-670 作者:  李亚军;  陆文聪;  杨晓燕;  朱维良   |  收藏  |  浏览/下载：21/0  |  提交时间：2019/01/08 DPP4  3D-QSAR  分子对接