中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Design, synthesis, and biological evaluation of thioamide-linked spiropyrrolidine derivatives as novel 3CL
pro
inhibitors against SARS-CoV-2
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 11
作者:
Guma, Samuel Desta
;
Song, Kang
;
Sun, Haiguo
;
Yang, Lei
;
Zhou, Zhaoyin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
SARS-CoV-2
3CL(pro) inhibitors
Thioamide derivatives
Spiropyrrolidine derivatives
Nirmatrelvir
HCoV-OC43
Antiviral
Metabolic stability
Long-circulating enzyme-activated HSP90-targeted camptothecin derivatives
期刊论文
OAI收割
JOURNAL OF CONTROLLED RELEASE, 2025, 卷号: 383, 页码: 16
作者:
Ding, Mengyuan
;
Shen, Qianqian
;
Su, Yi
;
Lu, Yingxin
;
Jin, Jiyu
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/07/25
eHSP90
Camptothecin derivatives
Cathepsin B
Long-circulating
Benzothiazole amide analogues as antagonists of TRPC 6 channels: A therapeutic approach for kidney fibrosis
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 291, 页码: 16
作者:
Ren, Chunlin
;
Xu, Qiding
;
Luo, Qiusi
;
Qiao, Xue
;
Ding, Taotao
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2025/06/23
Transient receptor potential canonical 6
channels
Antagonist
Renal fibrosis
Benzothiazole derivatives
Unilateral ureteral obstruction
Synthesis, photophysical properties and fluorescent application of novel [1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one derivatives
期刊论文
OAI收割
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2025, 卷号: 464, 页码: 11
作者:
Gan, Suya
;
Gao, Li-Xin
;
Cao, Zitong
;
Zhang, Chun
;
Fu, Yiqiu
  |  
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2025/04/01
[1
4]triazolo[1
5-a]pyrimidin-7(4H)-one
derivatives
Fluorescence properties
Fe 3+ions
Synthesis and biological evaluation of amino-conjugated bile acid derivatives against non-alcoholic steatohepatitis
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 122, 页码: 6
作者:
Wu, Zhitao
;
Zhang, Mingge
;
Yan, Meng Kun
;
Li, Chenyue
;
Pan, Guoyu
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2025/05/27
Non-alcoholic steatohepatitis (NASH)
Bile acid derivatives
Anti-lipid accumulation activities
Anti-inflammatory activities
Anti-fibrosis activities
Discovery of Hydrazineyl Amide Derivative of Pseudolaric Acid B for Reprogramming Tumor-Associated Macrophages Against Tumor Growth
期刊论文
OAI收割
MOLECULES, 2025, 卷号: 30, 期号: 10, 页码: 22
作者:
Peng, Xia
;
Yu, Siqi
;
Xu, Lin
;
Wang, Qinghua
;
Yang, Lin
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2025/07/25
pseudolaric acid B
amide derivatives
tumor-associated macrophages
anti-tumor
repolarization
Targeting Two Odorant-Binding Proteins in Acyrthosiphon pisum: Discovery of Novel Jasmone Derivatives as Aphid Repellents
期刊论文
OAI收割
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2025, 卷号: 73, 期号: 19, 页码: 11998-12013
作者:
Zhu, Ziwei
;
Li, Huilin
;
Zhu, Wenya
;
Du, Shaoqing
;
Yang, Zhaokai
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/06/23
odorant-binding proteins
jasmone derivatives
rational design
aphid repellents
insect behaviorregulators
Synthesis and Evaluation of Optical Properties, SHP2 Inhibitory Activity, and Cellular Imaging for Novel 2-Quinolone Derivatives
期刊论文
OAI收割
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2025, 页码: 10
作者:
Zhang, Chun
;
Yang, Yuting
;
Gao, Li-Xin
;
Gan, Suya
;
Li, Jia
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2025/05/27
Fluorescent inhibitors
SHP2
2-quinolone derivatives
optical properties
drug tracing
medical diagnosis
Harnessing Functional Food Sources: Deriving Anti-Inflammatory and Antibacterial Naphthalene Derivatives from the Edible Bulbs of
Eleutherine bulbosa
期刊论文
OAI收割
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2025, 卷号: 73, 期号: 7, 页码: 4126-4136
作者:
Gao, Yuan
;
Li, Ying
;
Zhou, Jun-Su
;
Zhao, Peng
;
Wu, Pei-Qian
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2025/04/01
Eleutherine bulbosa
bioactive components
naphthalene derivatives
anti-inflammatory
antibacterial
Design, synthesis, and structure-activity relationship studies of triazolo-pyrimidine derivatives as WRN inhibitors for the treatment of MSI tumors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 282, 页码: 21
作者:
Sui, Qibang
;
Zhou, Yuanyang
;
Li, Manjia
;
Wang, Dan
;
Cui, Rongrong
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/12/25
Synthetic lethal
MSI tumors
WRN inhibitors
Triazolo-pyrimidine derivatives