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浏览/检索结果: 共75条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择发表日期升序发表日期降序题名升序题名降序提交时间升序提交时间降序作者升序作者降序 HDAC inhibitor GCJ-490A modulates tumor microenvironment and synergizes with PD-1 antibody against breast and lung cancers in syngeneic murine models 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2025, 页码: 13 作者:  Zhang, Wen-xin;  He, Ting;  Fang, Kun;  Gao, Ying-lei;  Sun, Yi-ming   |  收藏  |  浏览/下载：3/0  |  提交时间：2025/12/04 HDAC inhibitor  GCJ-490A  tumor microenvironment  PD-1 antibody  CXCL7   Mechanism of hydroxamic acid group metabolism to carboxylic acid: Oxidation versus hydrolysis 期刊论文  OAI收割 DRUG METABOLISM AND DISPOSITION, 2025, 卷号: 53, 期号: 10, 页码: 11 作者:  Huang, Xiyue;  Zhou, Lei;  Chen, Huixian;  Sun, Xiaowei;  Cao, Mengyi   |  收藏  |  浏览/下载：2/0  |  提交时间：2025/12/04 Hydroxamic acid group  Bisthianostat  HDAC inhibitor  Cytochrome P450 enzymes  Oxidative cleavage   Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 3, 页码: 1659-1679 作者:  Jin, Yuheng;  Qi, Xuxin;  Yu, Xiaoli;  Cheng, Xirui;  Chen, Boya   |  收藏  |  浏览/下载：48/0  |  提交时间：2025/06/23 HDAC7  PROTAC  Selectivity  Hematologic malignancies  Non-enzymatic function   IHCH9033, a novel class I HDAC inhibitor, synergizes with FLT3 inhibitor and rescues quizartinib resistance in FLT3-ITD AML via enhancing DNA damage response 期刊论文  OAI收割 EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2025, 卷号: 14, 期号: 1, 页码: 19 作者:  Yao, Mingyue;  Yan, Wenzhong;  Wang, Yafang;  Zhao, Yu;  Xu, Xiaowei   |  收藏  |  浏览/下载：63/0  |  提交时间：2025/04/01 Acute myeloid leukemia  HDAC inhibitor  FLT3-ITD mutation  DNA damage response  Synergistic effect  Drug resistance   Design, Synthesis, and Biological Evaluation of HDAC Inhibitors Containing Natural Product-Inspired N-Linked 2-Acetylpyrrole Cap 期刊论文  OAI收割 MOLECULES, 2024, 卷号: 29, 期号: 19, 页码: 26 作者:  Zhang, Han;  Shen, Qianqian;  Hu, Zhu;  Wu, Pei-Qian;  Chen, Yi   |  收藏  |  浏览/下载：54/0  |  提交时间：2024/11/26 HDAC inhibitors  anti-cancer activity  natural products  pyrrole derivatives  molecular docking  molecular dynamics simulation   NIR-II fluorescence-guided liver cancer surgery by a small molecular HDAC6 targeting probe 期刊论文  OAI收割 EBIOMEDICINE, 2023, 卷号: 98, 页码: 18 作者:  Wang, Bo;  Tang, Chu;  Lin, En;  Jia, Xiaohua;  Xie, Ganyuan   |  收藏  |  浏览/下载：80/0  |  提交时间：2024/02/22 Hepatocellular carcinoma  Second near-infrared window  Molecular imaging  HDAC6  Fluorescence guided surgery   The intrinsic effects of using rhenium gaskets in hydrothermal diamond anvil cell experiments on background fluorescence, contamination, and redox control 期刊论文  OAI收割 CHEMICAL GEOLOGY, CHEMICAL GEOLOGY, 2023, 2023, 卷号: 632, 632, 页码: 14, 14 作者:  Cheng, Nanfei;  Chou, I. -Ming;  Wan, Ye;  Wang, Ruoheng;  Zhang, Haiyan   |  收藏  |  浏览/下载：64/0  |  提交时间：2023/10/07 HDAC  HDAC  Rhenium gasket  Raman spectroscopy  Background fluorescence  Contamination  Oxygen fugacity  Rhenium gasket  Raman spectroscopy  Background fluorescence  Contamination  Oxygen fugacity   Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 6, 页码: 2601-2612 作者:  Wang, Xiaomin;  Xu, Jun;  Sun, Yiming;  Cao, Siyuwei;  Zeng, Hanlin   |  收藏  |  浏览/下载：91/0  |  提交时间：2023/10/17 HDAC inhibitors  Drug resistance  Histone methylation  Histone acetylation  Epigenetic interplay  Hedgehog pathway  ZIC1  LIFR  Combination therapy  Breast cancer   The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKK? and overcomes gefitinib resistance in non-small cell lung cancer 期刊论文  OAI收割 CANCER BIOLOGY & MEDICINE, 2022, 卷号: 19, 期号: 8, 页码: 1172-1192 作者:  He, Ting;  Gao, Yinglei;  Fang, Yanfen;  Zhang, Yangming;  Zhang, Shuwei   |  收藏  |  浏览/下载：69/0  |  提交时间：2024/03/21 HDAC inhibitor  c-Met  IKK?  NSCLC  gefitinib   A novel aromatic amide derivative SY-65 co-targeted tubulin and histone deacetylase 1 with potent anticancer activity in vitro and in vivo 期刊论文  OAI收割 BIOCHEMICAL PHARMACOLOGY, 2022, 卷号: 201, 页码: 115070 作者:  Li, Yin-Ru;  Liu, Fang-Fang;  Liu, Wen-Bo;  Zhang, Yi-Fan;  Tian, Xin-Yi   |  收藏  |  浏览/下载：63/0  |  提交时间：2024/03/21 Epigenetic regulation  Tubulin  HDAC  Anticancer activity