机构

• 上海药物研究所 [34]
• 金属研究所 [4]
• 福建物质结构研究所 [2]
• 中国科学院大学 [2]
• 长春应用化学研究所 [2]
• 化学研究所 [1]
• 更多

采集方式

• OAI收割 [48]
• iSwitch采集 [2]

内容类型

• 期刊论文 [50]

发表日期

• 2024 [2]
• 2023 [1]
• 2022 [3]
• 2018 [3]
• 2017 [2]
• 2016 [4]
• 更多

学科主题

• Chemistry [12]
• Pharmacol... [10]
• Biochemist... [6]
• Computer S... [2]
• Biophysics [1]
• Biotechnol... [1]
• 更多

筛选

浏览/检索结果: 共50条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 7, 页码: 3286-3290 作者:  Zheng, Miao;  Feng, Bo;  Zhang, Yumin;  Liu, Xin;  Zhao, Na   |  收藏  |  浏览/下载：24/0  |  提交时间：2024/08/22 Non-covalent PLpro inhibitors  Antiviral activity  Structural-based drug design  Imidazo[4,5-b]pyridine scaffold   Structure-based development of potent and selective type-II kinase inhibitors of RIPK1 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334 作者:  Qin, Ying;  Li, Dekang;  Qi, Chunting;  Xiang, Huaijiang;  Meng, Huyan   |  收藏  |  浏览/下载：40/0  |  提交时间：2024/03/06 RIPK1  Necroptosis  Type-II kinase inhibitors  Rational design  Lead optimization  Structure-activity relationship  Anti-inflammation  Preclinical drug discovery   Development of PI3Kγ selective inhibitors: the strategies and application 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 10 作者:  Gu, Dong-Yan;  Zhang, Meng-Meng;  Li, Jia;  Zhou, Yu-Bo;  Sheng, Rong   |  收藏  |  浏览/下载：33/0  |  提交时间：2023/12/08 PI3K  PI3K gamma inhibitors  isoform selectivity  drug development  rational drug design   Triazine-Based Covalent DNA-Encoded Libraries for Discovery of Covalent Inhibitors of Target Proteins 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2022, 页码: 8 作者:  Li, Linjie;  Su, Mingbo;  Lu, Weiwei;  Song, Hongzhi;  Liu, Jiaxiang   |  收藏  |  浏览/下载：42/0  |  提交时间：2022/09/30 DNA encoded library  covalent library  library design  covalent inhibitors   Synthesis and Biochemical Evaluation of 8H-Indeno[1,2-d]thiazole Derivatives as Novel SARS-CoV-2 3CL Protease Inhibitors 期刊论文  OAI收割 MOLECULES, 2022, 卷号: 27, 期号: 10, 页码: 11 作者:  Wu, Jing;  Feng, Bo;  Gao, Li-Xin;  Zhang, Chun;  Li, Jia   |  收藏  |  浏览/下载：53/0  |  提交时间：2022/08/16 COVID-19  M-pro inhibitors  drug design and synthesis  structure-activity relationships (SAR)   Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 233, 页码: 18 作者:  Cao, Yu;  Tu, Yutong;  Fu, Liping;  Yu, Qian;  Gao, Lixin   |  收藏  |  浏览/下载：56/0  |  提交时间：2022/06/15 Metabolism  Design  Proteasome inhibitors  Non-covalent  Multiple myeloma   From hit to lead: Structure-based discovery of naphthalene-1 sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 154, 页码: 44-59 作者:  Gao, Ding-Ding;  Dou, Hui-Xia;  Su, Hai-Xia;  Zhang, Ming-Ming;  Wang, Ting   |  收藏  |  浏览/下载：49/0  |  提交时间：2019/01/08 FABP4 inhibitors  FABP3 sparing  Structure-based design strategy  X-ray crystallography   Design, synthesis and biological evaluation of tetrahydronaphthyridine derivatives as bioavailable CDK4/6 inhibitors for cancer therapy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 148, 页码: 140-153 作者:  Zha, Chuantao;  Deng, Wenjia;  Fu, Yan;  Tang, Shuai   |  收藏  |  浏览/下载：88/0  |  提交时间：2019/01/08 Structure-based drug design  Selective CDK4/6 inhibitors  Structure-activity relationship study  In vivo antitumor activity   antibacterialsorbicillinanddiketopiperazinesfromtheendogenousfunguspenicilliumspgd6associatedchinesemangrovebruguieragymnorrhiza 期刊论文  OAI收割 chinesejournalofnaturalmedicines, 2018, 卷号: 16, 期号: 5, 页码: 358 作者:  Jiang Chengshi;  Zhou Zhenfang;  Yang Xiaohong;  Lan Lefu;  Gu Yucheng   |  收藏  |  浏览/下载：21/0  |  提交时间：2020/07/01 ANALOGS  INHIBITORS  DESIGN  Mangrove  Penicillium sp.  Sorbicillin derivative  Diketopiperazine alkaloids   discoveryofpotent24difluorolinkerpolyadpribosepolymerase1inhibitorswithenhancedwatersolubilityandinvivoanticancerefficacy 期刊论文  OAI收割 actapharmacologicasinica, 2017, 卷号: 38, 期号: 11, 页码: 1521 作者:  Chen Wenhua;  Song Shanshan;  Ql Minghui;  Huan Xiajuan;  Wang Yingqing   |  收藏  |  浏览/下载：33/0  |  提交时间：2020/07/01 PARP INHIBITORS  MEDICINAL CHEMISTRY  DRUG DISCOVERY  CANCER  THERAPY  DESIGN  FLUORINE  SUCCESS  PREDICT  METRICS  PARP-1 inhibitor  olaparib  breast cancer  BRCA-deficient tumors